Showing entry for Thyrotropin receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008234
Protein NameThyrotropin receptor
Uniport IdP16473
GeneTSHR
Gene Id7253
Domain7tm_1; LRR_5
Pfam PF00001   PF13306  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04024 cAMP signaling pathway
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.2 Endocrine system hsa04918 Thyroid hormone synthesis
5. Organismal Systems 5.2 Endocrine system hsa04923 Regulation of lipolysis in adipocytes
6. Human Diseases 6.3 Immune diseases hsa05320 Autoimmune thyroid disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007190 activation of adenylate cyclase activity
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007267 cell-cell signaling
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:1904588 cellular response to glycoprotein
Biological Process GO:1905229 cellular response to thyrotropin-releasing hormone
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Process GO:0009755 hormone-mediated signaling pathway
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0120162 positive regulation of cold-induced thermogenesis
Biological Process GO:0038194 thyroid-stimulating hormone signaling pathway
molecular function GO:0008528 G protein-coupled peptide receptor activity
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:0004996 thyroid-stimulating hormone receptor activity
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0009986 cell surface
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-372790 Signaling by GPCR
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-375281 Hormone ligand-binding receptors
R-HSA-388396 GPCR downstream signalling
R-HSA-418555 G alpha (s) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-5663205 Infectious disease
R-HSA-9658195 Leishmania infection
R-HSA-9660821 ADORA2B mediated anti-inflammatory cytokines production
R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection
R-HSA-9664433 Leishmania parasite growth and survival
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000731 BXGD000002 Abdomen distended Digestive System Diseases
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001430 BXGD000054 Adenoma Neoplasms
C0001624 BXGD000067 Adrenal Gland Neoplasms Neoplasms; Endocrine System Diseases
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0006905 BXGD000419 Capillary Fragility
C0007097 BXGD000424 Carcinoma Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007133 BXGD000442 Carcinoma, Papillary Neoplasms
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0007867 BXGD000497 Cervix Diseases Female Urogenital Diseases and Pregnancy Complications
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010308 BXGD000661 Congenital Hypothyroidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0015300 BXGD000973 Exophthalmos Eye Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0016053 BXGD001041 Fibromyalgia Musculoskeletal Diseases; Nervous System Diseases
C0018021 BXGD001162 Goiter Endocrine System Diseases
C0018023 BXGD001164 Nodular Goiter Endocrine System Diseases
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0020450 BXGD001388 Hyperemesis Gravidarum Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0023487 BXGD001669 Acute Promyelocytic Leukemia Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024232 BXGD001751 Lymphatic Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0024421 BXGD001770 Macroglossia Stomatognathic Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026267 BXGD001896 Mitral Valve Prolapse Syndrome Cardiovascular Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027121 BXGD001973 Myositis Musculoskeletal Diseases; Nervous System Diseases
C0027145 BXGD001978 Myxedema Skin and Connective Tissue Diseases; Endocrine System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028259 BXGD002073 Nodule
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029132 BXGD002117 Disorder of the optic nerve Eye Diseases; Nervous System Diseases
C0029182 BXGD002121 orbit (eye disorders) Eye Diseases
C0029434 BXGD002146 Osteogenesis Imperfecta Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0033103 BXGD002395 Pretibial myxedema Skin and Connective Tissue Diseases; Endocrine System Diseases
C0033844 BXGD002435 Pseudotumor Pathological Conditions, Signs and Symptoms
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0039231 BXGD002799 Tachycardia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0040021 BXGD002834 Thromboangiitis Obliterans Cardiovascular Diseases
C0040115 BXGD002841 Thymus Hyperplasia Hemic and Lymphatic Diseases
C0040127 BXGD002843 Thyroid Crisis Endocrine System Diseases
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040137 BXGD002846 Thyroid Nodule Neoplasms; Endocrine System Diseases
C0040147 BXGD002847 Thyroiditis Endocrine System Diseases
C0040149 BXGD002848 Subacute thyroiditis Endocrine System Diseases
C0040156 BXGD002849 Thyrotoxicosis Endocrine System Diseases
C0041408 BXGD002923 Turner Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0085278 BXGD003150 Antiphospholipid Syndrome Immune System Diseases
C0085409 BXGD003168 Polyendocrinopathies, Autoimmune Immune System Diseases; Endocrine System Diseases
C0085631 BXGD003214 Agitation Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0086692 BXGD003306 Benign Neoplasm Neoplasms
C0151468 BXGD003424 Thyroid Gland Follicular Adenoma Neoplasms; Endocrine System Diseases
C0151514 BXGD003429 Atrophic condition of skin Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0151516 BXGD003430 Thyroid Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0152226 BXGD003562 Lagophthalmos Eye Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0154143 BXGD003704 Toxic multinodular goiter Endocrine System Diseases
C0158983 BXGD003915 Neonatal thyrotoxicosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C0162538 BXGD003954 Immunoglobulin A deficiency (disorder) Immune System Diseases; Hemic and Lymphatic Diseases
C0178468 BXGD004029 Autoimmune thyroid disease Immune System Diseases; Endocrine System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202239 BXGD004087 Uric acid measurement (procedure)
C0205642 BXGD004094 Adenocarcinoma, Oxyphilic Neoplasms
C0205646 BXGD004098 Adenoma, Basal Cell Neoplasms
C0205647 BXGD004099 Follicular adenoma Neoplasms
C0205648 BXGD004100 Adenoma, Microcystic Neoplasms
C0205649 BXGD004101 Adenoma, Monomorphic Neoplasms
C0205650 BXGD004102 Papillary adenoma Neoplasms
C0205651 BXGD004103 Adenoma, Trabecular Neoplasms
C0205696 BXGD004107 Anaplastic carcinoma Neoplasms
C0205697 BXGD004108 Carcinoma, Spindle-Cell Neoplasms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0205699 BXGD004110 Carcinomatosis Neoplasms
C0206139 BXGD004159 Lichen Planus, Oral Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0206682 BXGD004237 Follicular thyroid carcinoma Neoplasms
C0206693 BXGD004244 Medullary carcinoma Neoplasms
C0221232 BXGD004413 Welts Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0232466 BXGD004543 Feeding difficulties
C0235991 BXGD004802 Small for gestational age (disorder) Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications
C0238185 BXGD004889 Juvenile myxedema Skin and Connective Tissue Diseases; Endocrine System Diseases
C0238461 BXGD004936 Anaplastic thyroid carcinoma Neoplasms
C0238462 BXGD004937 Medullary carcinoma of thyroid Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0239842 BXGD005001 Tremor of hands
C0241910 BXGD005123 Autoimmune Chronic Hepatitis Digestive System Diseases; Immune System Diseases
C0242292 BXGD005146 McCune-Albright Syndrome Musculoskeletal Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0271742 BXGD006254 Glucocorticoid deficiency with achalasia Digestive System Diseases; Endocrine System Diseases
C0271789 BXGD006258 Hypothyroidism, Congenital, Nongoitrous, 4 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0271790 BXGD006259 Subclinical hypothyroidism Endocrine System Diseases
C0271791 BXGD006260 Severe hypothyroidism Endocrine System Diseases
C0271814 BXGD006263 Silent thyroiditis Endocrine System Diseases
C0271815 BXGD006264 Postpartum Thyroiditis Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0271829 BXGD006267 Pendred's syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Endocrine System Diseases; Otorhinolaryngologic Diseases
C0278704 BXGD006567 Malignant Childhood Neoplasm Neoplasms
C0302511 BXGD006849 Small for gestational age fetus Pathological Conditions, Signs and Symptoms
C0302840 BXGD006855 Toxic thyroid adenoma Neoplasms; Endocrine System Diseases
C0311361 BXGD006880 Adenomatous goiter Neoplasms; Endocrine System Diseases
C0339143 BXGD007226 Thyroid associated opthalmopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0342114 BXGD007430 Diffuse goiter Endocrine System Diseases
C0342122 BXGD007431 Toxic diffuse goiter Endocrine System Diseases
C0342127 BXGD007432 Toxic nodular goiter Endocrine System Diseases
C0342136 BXGD007433 Autonomous thyroid function Endocrine System Diseases
C0342138 BXGD007434 Thyrotoxicosis in pregnancy Endocrine System Diseases
C0342153 BXGD007436 Congenital thyroid hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C0342158 BXGD007437 Hypothyroidism, Autoimmune Immune System Diseases; Endocrine System Diseases
C0342162 BXGD007438 Compensated hypothyroidism Endocrine System Diseases
C0342190 BXGD007440 C-cell hyperplasia of thyroid Pathological Conditions, Signs and Symptoms; Endocrine System Diseases
C0342191 BXGD007441 Familial dyshormonogenetic goiter Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0342199 BXGD007443 Iodine deficiency syndrome Endocrine System Diseases
C0342200 BXGD007444 Endemic Cretinism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0342208 BXGD007445 Multinodular goiter Neoplasms; Endocrine System Diseases
C0342549 BXGD007504 Familial Testotoxicosis Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0393639 BXGD008110 Hashimoto's encephalitis Nervous System Diseases; Endocrine System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0456132 BXGD008869 Large fontanelle
C0474808 BXGD008959 Follicular neoplasm Neoplasms
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0545053 BXGD009323 Advanced bone age
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0557874 BXGD009444 Global developmental delay
C0578870 BXGD009553 Chronic idiopathic urticaria Skin and Connective Tissue Diseases; Immune System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0586553 BXGD009609 Raised TSH level Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600086 BXGD009689 Toxic goiter Endocrine System Diseases
C0677607 BXGD009721 Hashimoto Disease Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0700502 BXGD009893 Acquired hypothyroidism Endocrine System Diseases
C0741899 BXGD010042 Poorly differentiated carcinoma
C0749420 BXGD010216 Thyroid Agenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C0749424 BXGD010217 Thyroid Hurthle Cell Carcinoma Neoplasms; Endocrine System Diseases
C0750887 BXGD010240 Adrenal Cancer Neoplasms; Endocrine System Diseases
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0856120 BXGD011093 Multiple sclerosis relapse
C0869147 BXGD011304 Neonatal hyperthyroidism Endocrine System Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0917799 BXGD011410 Hypersomnia Nervous System Diseases; Mental Disorders
C0920350 BXGD011466 Autoimmune thyroiditis Immune System Diseases; Endocrine System Diseases
C0947751 BXGD011494 Vascular inflammations Cardiovascular Diseases
C0948192 BXGD011514 Primary infection NOS
C1096666 BXGD011638 Thyroid cancer metastatic Neoplasms; Endocrine System Diseases
C1112776 BXGD011687 Thyroid hyperplasia
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1262091 BXGD011867 Lymphocytic infiltration
C1262098 BXGD011868 Congenital hyperthyroidism Endocrine System Diseases
C1262477 BXGD011882 Weight decreased Pathological Conditions, Signs and Symptoms
C1269955 BXGD012005 Tumor Cell Invasion
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1304508 BXGD012341 Spindle cell hemangioma Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1337013 BXGD012876 Differentiated Thyroid Gland Carcinoma
C1400126 BXGD013010 Thyroid hypertrophy
C1456145 BXGD013108 Dental caries of smooth surface Stomatognathic Diseases
C1510502 BXGD013175 Oxyphilic Adenoma Neoplasms
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1563716 BXGD013390 Thyroid Dysgenesis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C1578691 BXGD013428 Myxedema, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C1608408 BXGD013434 Malignant transformation
C1611743 BXGD013456 Familial (FPAH)
C1709457 BXGD013625 Papillary Thyroid Microcarcinoma Neoplasms; Endocrine System Diseases
C1836706 BXGD014153 Hyperthyroidism, Nonautoimmune Endocrine System Diseases
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1846135 BXGD014784 Autistic features
C1853237 BXGD015319 Isolated cases
C1854301 BXGD015391 Motor delay Mental Disorders
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1859592 BXGD015912 ATRICHIA WITH PAPULAR LESIONS Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1863959 BXGD016205 Hyperthyroidism, Familial Gestational Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1863960 BXGD016206 Thyroid Adenoma, Hyperfunctioning Endocrine System Diseases
C1863961 BXGD016207 Thyroid Carcinoma With Thyrotoxicosis Endocrine System Diseases
C1864761 BXGD016248 Thyroid Hormone Metabolism, Abnormal Endocrine System Diseases
C1955741 BXGD016606 Glucocorticoid deficiency
C1963060 BXGD016679 Agitation, CTCAE 3.0
C1963094 BXGD016681 Dry Skin, CTCAE
C1998045 BXGD016866 Subclinical hyperthyroidism Endocrine System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2315100 BXGD017021 Pediatric failure to thrive Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases; Mental Disorders
C2678303 BXGD017402 Hoarse cry Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Nervous System Diseases; Otorhinolaryngologic Diseases
C2745900 BXGD017568 Promyelocytic leukemia
C2747905 BXGD017582 Destructive thyroiditis
C2919142 BXGD017867 Short Stature, CTCAE
C2931367 BXGD018010 Thyroid cancer, follicular Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2940785 BXGD018183 HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C2940786 BXGD018184 Thyroid Hormone Resistance Syndrome Endocrine System Diseases
C3493776 BXGD018955 HYPOTHYROIDISM, CONGENITAL, NONGOITROUS, 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C3541994 BXGD019100 Drug Hypersensitivity Syndrome Skin and Connective Tissue Diseases; Immune System Diseases; Chemically-Induced Disorders
C3714618 BXGD019417 Primary Hyperthyroidism Endocrine System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3715197 BXGD019449 Primary congenital hypothyroidism
C3826150 BXGD019714 Hypothyroidism in children
C3827793 BXGD019739 Transient hypothyroxinaemia of prematurity
C3840565 BXGD019797 Autoimmune thyroid disease (AITD)
C3887638 BXGD019906 Failure to thrive in infant Pathological Conditions, Signs and Symptoms
C3887709 BXGD019918 Optic Neuropathy Eye Diseases; Nervous System Diseases
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4023188 BXGD021140 Activating thyroid-stimulating hormone receptor defect
C4225553 BXGD022280 THYROID CARCINOMA WITH THYROTOXICOSIS, SOMATIC
C4302198 BXGD022528 Familial hyperthyroidism Endocrine System Diseases
C4316995 BXGD022715 Primary Hypothyroidism Endocrine System Diseases
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4552855 BXGD023528 Agitation, CTCAE 5.0
C4721555 BXGD023755 Autoimmune hepatitis Digestive System Diseases
C4722172 BXGD023791 Primary differentiated carcinoma of thyroid gland
C4722330 BXGD023801 Generalized Thyroid Hormone Resistance Endocrine System Diseases
C4722488 BXGD023805 Thyroid Stimulating Hormone Resistance
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000076 p-Coumaroyl tartaric acid glucosidic ester 150.09
BXGC0000099 3,4-Dihydroxyphenylacetic acid 168.15
BXGC0000130 Estradiol 272.38
BXGC0000194 Sanguinarine 332.33
BXGC0000202 Papaverine 339.39
BXGC0000211 L-Stachydrine 143.18
BXGC0000245 NG,NG-Dimethyl-L-arginine 202.25
BXGC0000434 Ethanol 46.07
BXGC0000437 Nonane 128.26
BXGC0000445 Pentane 72.15
BXGC0000446 2-Aminoethanol 61.08
BXGC0000473 2-Methylbenzaldehyde 120.15
BXGC0000478 2,4,6-Tribromophenol 330.8
BXGC0000484 2,4,5-Trimethoxybenzaldehyde 196.2
BXGC0000500 2,4-Dihydroxybenzoic acid 154.12
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000549 Urocanic acid 138.12
BXGC0000573 Dantron 240.21
BXGC0000642 4-Aminobenzoic acid 137.14
BXGC0000661 Cellulase 288.42
BXGC0000895 5-Hydroxyindole-3-acetic acid 191.18
BXGC0001238 3-Methoxy-4-hydroxyphenylacetic acid 182.17
BXGC0001325 Progesterone 314.46
BXGC0001544 Harmaline 214.26
BXGC0001550 Ficus Latex peptide 2 244.26
BXGC0001615 (E)-Zeatin 219.24
BXGC0001623 L-Tryptophan 204.23
BXGC0001630 Arginine 174.2
BXGC0001789 Silibinin 482.44
BXGC0001842 Bergapten 216.19
BXGC0001881 Chrysophanol 254.24
BXGC0001962 Hesperetin 302.28
BXGC0002069 Anethole 148.2
BXGC0002071 Apigenin 270.24
BXGC0002187 Octadecanoic acid 284.48
BXGC0002248 Dodecanoic acid 200.32
BXGC0002392 Pentanal 86.13
BXGC0002419 Isopropyl acetate 102.13
BXGC0002424 2-Methyl-1-propanol 74.12
BXGC0002436 Fumaric acid 116.07
BXGC0002468 Octanoic acid 144.21
BXGC0002502 2-Butanol 74.12
BXGC0002572 Dimethyl disulfide 94.2
BXGC0002610 Aniline 93.13
BXGC0002690 alpha-Catechin 290.27
BXGC0002736 cis-Carveol 152.24
BXGC0002794 N-Methylaniline 107.15
BXGC0002957 di-(2-Methylpropyl)-phthalate 278.34
BXGC0002971 alpha-Lipoic acid 206.33
BXGC0003107 Cyclopentanol 86.13
BXGC0003131 N,N-Dimethylformamide 73.09
BXGC0003188 Pinene 136.24
BXGC0003218 Foluene 92.14
BXGC0003249 5-Hexyl-2-methylpyridine 270.37
BXGC0003254 Isoprene 68.12
BXGC0003396 Legumelin 394.42
BXGC0003473 1,2-Dimethylbenzene 106.17
BXGC0003610 5-Hydroxy-L-tryptophan 220.22
BXGC0003627 alpha-Linoleic acid 280.45
BXGC0003647 Ethyl linilenate 306.49
BXGC0003707 Estrogen 268.36
BXGC0004139 Sperminidine 145.25
BXGC0004144 Heptanal 114.19
BXGC0004159 1-Hexanol 102.17
BXGC0004192 Methanol 32.04
BXGC0004222 2-Methyl-3-phenyl-2-propenal 146.19
BXGC0004252 1-Penten-3-one 84.12
BXGC0004275 Acetaldehyde 44.05
BXGC0004282 (E)-Aconitic acid 174.11
BXGC0004283 2-Propenal 56.06
BXGC0004287 Allyl alcohol 58.08
BXGC0004548 4-(beta-Methylaminoethyl)catechol 167.21
BXGC0004560 Benzoic acid 122.12
BXGC0004565 Benzyl alcohol 108.14
BXGC0004580 Carbanilide 212.25
BXGC0004594 Dibenzyl ether 198.26
BXGC0004653 3,4-Dimethoxybenzaldehyde 166.17
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0004667 Betaine 117.15
BXGC0004764 (R)-Octopamine 153.18
BXGC0004965 Rhein 284.22
BXGC0004969 1,4,5-Naphthalenetriol 176.17
BXGC0005165 4-Methylthiazole 99.15
BXGC0005254 Dibutyl phthalate 278.34
BXGC0005624 Genistein 270.24
BXGC0005668 2-Methoxyphenol 124.14
BXGC0005683 Quercetin 302.24
BXGC0005697 2,3-Butanedione 86.09
BXGC0005762 Dimethyl succinate 146.14
BXGC0005771 Decanoic acid 172.26
BXGC0005867 Serotonin 176.22
BXGC0005894 Azelaic acid 188.22
BXGC0005897 Methyl benzoate 136.15
BXGC0005982 Curcumin 368.38
BXGC0006060 1-Methoxy-4-(2-propenyl)benzene 148.2
BXGC0006092 3-Isothiocyanato-1-propene 99.15
BXGC0006105 Methyl salicylate 152.15
BXGC0006108 1H-Imidazole-4(5)-acetic acid 126.11
BXGC0006115 Xanthotoxin 216.19
BXGC0006156 Dicoumarol 336.3
BXGC0006173 Styrene 104.15
BXGC0006247 N,N-Dimethylbenzylamine 135.21
BXGC0006300 5-Hydroxymethyl-2-furancarboxaldehyde 126.11
BXGC0006389 Rotenone 394.42
BXGC0006391 Benzene 78.11
BXGC0006400 Diphenyl ether 170.21
BXGC0006422 Mercenene 214.05
BXGC0006586 (??)-2-Hydroxy-2-phenylacetonitrile 133.15
BXGC0006635 Luteolin 286.24
BXGC0007014 Harman 182.22
BXGC0007029 Emodin 270.24
BXGC0007499 Boric acid (H3BO3) 61.83
BXGC0007524 3-(Dimethylaminomethyl)indole 174.24
BXGC0007530 Folic acid 441.4
BXGC0007601 1,8-Cineole 154.25
BXGC0007675 Pyridine 79.1
BXGC0007812 Menthofuran 150.22
BXGC0007835 (-)-3-Isothujone 152.23
BXGC0008059 1-Aminocyclopropanecarboxylic acid 101.1
BXGC0008168 7-Methylchrysin 268.26
BXGC0008184 Phloretin 274.27
BXGC0009308 Carvyl acetate 194.27
BXGC0009409 7-Methyl-3-methylene-1,6-octadiene 136.24
BXGC0009649 Dihydrocapsaicin 307.43
BXGC0010354 Cytokinin B 225.25
BXGC0011084 Pentanenitrile 83.13
BXGC0011258 beta-Fructofuranosidase 261.94
BXGC0012243 Ukonan D 151.16
BXGC0012352 Chelerythrine 348.12
BXGC0012430 Methyl (1S,15R,17S,18S,19R,20R)-6,18-Dimethoxy-17-(3,4,5-Trimethoxybenzoyl)Oxy-1,3,11,12,14,15,16,17,18,19,20,21-Dodecahydroyohimban-19-Carboxylate 608.27
BXGC0013304 4-Azaniumylbenzenesulfonate 173.01
BXGC0013359 (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid 180.04
BXGC0013544 Naphthalen-1-Amine 143.07
BXGC0013854 Histamine 111.08
BXGC0014019 (2S,3S)-2-Amino-3-Hydroxybutanedioic Acid 149.03
BXGC0014695 Loratadine 382.14
BXGC0015031 Diethyl Phthalate 222.09
BXGC0015236 (6R)-6-[(5R)-6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl]-6H-Furo[3,4-G][1,3]Benzodioxol-8-One 367.11
BXGC0015879 Chlorhexidine 504.2
BXGC0016266 Butoxyethanol 118.1
BXGC0016468 (2S)-2-Hydroxy-2-(4-Hydroxy-3-Methoxyphenyl)Acetic Acid 198.05
BXGC0016470 Camptothecin 348.11
BXGC0016640 2,2-Dimethylbutane 86.11
BXGC0016891 Nortriptyline 263.17
BXGC0017100 1,2-Dichlorobenzene 145.97
BXGC0017313 (2R)-1-(Propan-2-Ylamino)-3-(2-Prop-2-Enylphenoxy)Propan-2-Ol 249.17
BXGC0017443 Phenylephrine 167.09
BXGC0018073 2-Phenylethyl (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoate 284.1
BXGC0018099 [(4S)-2,5-Dioxoimidazolidin-4-Yl]Urea 158.04
BXGC0018397 beta-1,4-mannan 180.06
BXGC0018736 Benzamide 121.05
BXGC0018772 Pseudoephedrine 165.12
BXGC0019164 Raloxifene 473.17
BXGC0020317 1,2-Dimethylnaphthalene 156.09
BXGC0020460 chloroacetic acid 93.98
BXGC0020800 Testosterone 288.21
BXGC0020884 Thiourea 76.01
BXGC0021553 Perillic Acid 166.1
BXGC0021870 Abscisic Acid 264.14
BXGC0021928 3-(2-Carboxyethyldisulfanyl)Propanoic Acid 210
BXGC0022629 Bis(2-Methoxyethyl) Benzene-1,2-Dicarboxylate 282.11
BXGC0023039 (10-Acetyloxy-8,8-Dimethyl-2-Oxo-9,10-Dihydropyrano[2,3-F]Chromen-9-Yl) 3-Methylbutanoate 388.15
BXGC0023187 1-Hexene 84.09
BXGC0023415 (E)-Pent-3-Enenitrile 81.06
BXGC0023773 ethylene dichloride 97.97
BXGC0024863 (2R)-5-Amino-2-Azaniumyl-5-Oxopentanoate 146.07
BXGC0024915 Dehydroglaucine 353.16
BXGC0024988 Nifedipine 346.12
BXGC0025017 Bergamottin 338.15
BXGC0025325 Methysticin 274.08
BXGC0025757 Calcimycin 523.27
BXGC0026698 2-Hydroxyethyl Prop-2-Enoate 116.05
BXGC0027182 5-Methoxy-5-Oxopentanoic Acid 146.06
BXGC0027374 Glyburide 493.14
BXGC0027480 (2E,4E)-Deca-2,4-Dienal 152.12
BXGC0028278 Rutaecarpine 287.11
BXGC0028870 2-Ethylhexanal 128.12
BXGC0029148 Gitoxigenin 390.24
BXGC0029784 Fumaric Acid 116.01
BXGC0030138 Colchicine 399.17
BXGC0030553 3-(4-Tert-Butylphenyl)-2-Methylpropanal 204.15
BXGC0030815 (S)-Verapamil 454.28
BXGC0031384 Epinephrine 183.09
BXGC0032684 Pyrene 202.08
BXGC0034006 Fluoranthene 202.08
BXGC0034077 (2Z,4Z)-5-(1,3-Benzodioxol-5-Yl)-1-Piperidin-1-Ylpenta-2,4-Dien-1-One 285.14
BXGC0035201 Quinidine 324.18
BXGC0036043 Demethylfuropinnarin 270.09
BXGC0036362 Sodium Lauryl Sulfate 265.15
BXGC0036905 2-Methylpentan-1-Ol 102.1
BXGC0037407 Lithocholic Acid 376.3
BXGC0037718 Ethacrynic Acid 302.01
BXGC0037911 Oxolane-2,5-Dione 100.02
BXGC0038154 D-Aspartate 133.04
BXGC0038963 Dichlorvos 219.95
BXGC0039046 Digitonin 1228.57
BXGC0039319 Muscarine 174.15
BXGC0039507 Digitoxigenin 374.25
BXGC0039684 Berberine Chloride 336.12
BXGC0040358 Lobaric Acid 456.18
BXGC0041078 2-Tert-Butylphenol 150.1
BXGC0041414 protopine 353.13
BXGC0041418 Bis(2-Ethylhexyl) Hexanedioate 370.31
BXGC0041894 Questiomycin B 109.05
BXGC0042091 Dequalinium 456.33
BXGC0042127 Oxyquinoline 145.05
BXGC0042240 3-(Furan-3-Yl)-3A,7-Dimethyl-3,4,5,6-Tetrahydro-2-Benzofuran-1-One 232.11
BXGC0042562 Acrylamide 71.04
BXGC0042648 (1S)-1-Methyl-1,2,3,4-Tetrahydroisoquinoline-6,7-Diol 179.09
BXGC0042708 3-Chlorophenol 128
BXGC0042852 Skimmianine 259.08
BXGC0043229 Acetyl Acetate 102.03
BXGC0043639 1-Tert-Butyl-2-Methoxy-4-Methyl-3,5-Dinitrobenzene 268.11
BXGC0043875 Karanjin 292.07
BXGC0044598 Guvacine 127.06
BXGC0044857 Sp-600125 220.06
BXGC0045252 Sc-560 352.06
BXGC0045254 Sb-202190 331.11
BXGC0045746 Diphenyleneiodonium 278.97
BXGC0045812 Trifluoperazine 407.16
BXGC0046510 Tpck 351.07
BXGC0046559 Paraxanthine 180.06
BXGC0046918 Kinetin 215.08
BXGC0047127 Hydron;2,3,9,10-Tetramethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline;Chloride 355.18
BXGC0047281 Berberine 336.12
BXGC0047568 Retinol 286.23
BXGC0047867 Dalfampridine 94.05
BXGC0048267 Canavanine 176.09
BXGC0049049 Haplamine 257.11
BXGC0049391 Betadex 1134.37
BXGC0049402 Decyl 2-Methylprop-2-Enoate 226.19
BXGC0049647 1R,9S-Hydrastine 383.14
BXGC0049738 Dexibuprofen 206.13
BXGC0049926 Conessine 356.32
BXGC0050008 Strophanthidin 404.22
BXGC0050013 (6S)-6-[(5R)-6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl]-6H-Furo[3,4-G][1,3]Benzodioxol-8-One 367.11
BXGC0050194 alpha-D-Mannose 180.06
BXGC0050471 Fluorouracil 130.02
BXGC0051013 N-Phenylnaphthalen-1-Amine 219.1
BXGC0051342 Valerenic Acid 234.16
BXGC0052272 Oct-1-Ene 112.13
BXGC0052374 Reserpine 608.27
BXGC0052878 Bisphenol A 228.12
BXGC0053114 Propylparaben 180.08
BXGC0053486 Phenanthrene 178.08
BXGC0053544 Actein 676.38
BXGC0053629 Esatenolol 266.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein