Showing entry for 4',7-Dimethoxy-5-Hydroxygenistein


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0014649
Compound Name4',7-Dimethoxy-5-Hydroxygenistein
Structure
FormulaC17H14O5
InchiKeyDQNLRFRBAWCJHQ-UHFFFAOYSA-N
SMILESCOc1ccc(cc1)c1coc2c(c1=O)c(O)cc(c2)OC
InchiInChI=1S/C17H14O5/c1-20-11-5-3-10(4-6-11)13-9-22-15-8-12(21-2)7-14(18)16(15)17(13)19/h3-9,18H,1-2H3
IUPAC5-hydroxy-7-methoxy-3-(4-methoxyphenyl)chromen-4-one
Molecular Weight298.08
Pubchem Id5386259
Chembl IdCHEMBL464433
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 49475
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012754 Transcription factor p65 reviewed Transcription factor RELA - - - 1725
CHEMBL CHEMBL464433
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 8912 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 39810 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 '=' 25118 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 631 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 1000 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 '=' 2818 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 12589 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 651 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Activity - - -
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA EC50 '=' 1725 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 EC50 '=' 1725 nM
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit reviewed Transcription factor NFKB2 EC50 '=' 1725 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 '=' 35 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 3162 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 2511 nM
Q60795 BXGT016000 Nuclear factor erythroid 2-related factor 2 reviewed - Nfe2l2 Activity - - -
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 79432 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 1510 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 89125 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 23109 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 T1/2 '=' 0 hr
Q60795 BXGT016000 Nuclear factor erythroid 2-related factor 2 reviewed - Nfe2l2 FC '=' 2 -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Inhibition - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF01068 Inulanthera calva Inulanthera calva Others
BXGF01318 Nicotiana raimondii Nicotiana raimondii Others
BXGF01846 Klasea sogdiana Klasea sogdiana Others
BXGF02139 Scolopia chinensis Scolopia chinensis Others
BXGF04284 Heliotropium hirsutissimum Heliotropium hirsutissimum Others
BXGF05212 Trollius europaeus Trollius europaeus Medicinal Plant
BXGF05402 Myristica malabarica Myristica malabarica Medicinal Plant
BXGF05991 Asclepias vestita Asclepias vestita Others
BXGF06294 Arum maximum Arum maximum Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease