Showing entry for Regulator of G-protein signaling 4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010745
Protein NameRegulator of G-protein signaling 4
Uniport IdP49798
GeneRGS4
Gene Id5999
DomainRGS
Pfam PF00615  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007420 brain development
Biological Process GO:1990791 dorsal root ganglion development
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0000188 inactivation of MAPK activity
Biological Process GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
Biological Process GO:0060160 negative regulation of dopamine receptor signaling pathway
Biological Process GO:1900924 negative regulation of glycine import across plasma membrane
Biological Process GO:0045744 negative regulation of G protein-coupled receptor signaling pathway
Biological Process GO:1901380 negative regulation of potassium ion transmembrane transport
Biological Process GO:2000463 positive regulation of excitatory postsynaptic potential
Biological Process GO:0010460 positive regulation of heart rate
Biological Process GO:0110053 regulation of actin filament organization
Biological Process GO:0051924 regulation of calcium ion transport
Biological Process GO:0008277 regulation of G protein-coupled receptor signaling pathway
Biological Process GO:0001975 response to amphetamine
Biological Process GO:0042220 response to cocaine
Biological Process GO:0045471 response to ethanol
Biological Process GO:0043278 response to morphine
molecular function GO:0005516 calmodulin binding
molecular function GO:0001965 G-protein alpha-subunit binding
molecular function GO:0005096 GTPase activator activity
molecular function GO:0003924 GTPase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0032991 protein-containing complex
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004936 BXGD000295 Mental disorders Mental Disorders
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005686 BXGD000320 Urinary Bladder Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0013386 BXGD000827 Dyskinesia, Drug-Induced Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0016667 BXGD001072 Fragile X Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029095 BXGD002108 Opioid abuse Chemically-Induced Disorders; Mental Disorders
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038273 BXGD002743 Stereotypic Movement Disorder Mental Disorders
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0154748 BXGD003740 Lesion of Sciatic Nerve Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0269102 BXGD006053 Endometrioma Female Urogenital Diseases and Pregnancy Complications
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0853193 BXGD010968 Bipolar I disorder Mental Disorders
C0871099 BXGD011311 positive and negative symptoms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C2063866 BXGD016906 Depressive Disorder, Treatment-Resistant Mental Disorders
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000099 3,4-Dihydroxyphenylacetic acid 168.15
BXGC0000191 Tyramine 137.18
BXGC0000194 Sanguinarine 332.33
BXGC0000430 Gossypol 518.55
BXGC0000530 Hydroquinone 110.11
BXGC0000895 5-Hydroxyindole-3-acetic acid 191.18
BXGC0000985 Putrescine 88.15
BXGC0000988 3' 5'-cyclic AMP 329.21
BXGC0001002 1,2-Benzenediol 110.11
BXGC0001238 3-Methoxy-4-hydroxyphenylacetic acid 182.17
BXGC0001589 Arecoline 155.19
BXGC0001626 3-Aminopropanoic acid 89.09
BXGC0001767 (E)-Resveratrol 228.25
BXGC0001899 Daidzein 254.24
BXGC0001940 Daphnetin 178.14
BXGC0002018 Morin 302.24
BXGC0002071 Apigenin 270.24
BXGC0002374 Taurine 125.15
BXGC0002605 Adenosine 267.24
BXGC0002796 Nicotine 162.23
BXGC0002906 Caffeic acid ester 284.31
BXGC0002916 Melatonin 232.28
BXGC0003418 Undylic acid 324.18
BXGC0003596 Charantin 473.57
BXGC0003610 5-Hydroxy-L-tryptophan 220.22
BXGC0003707 Estrogen 268.36
BXGC0003894 Phospholipase 343.36
BXGC0004276 Acetamide 59.07
BXGC0004548 4-(beta-Methylaminoethyl)catechol 167.21
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0004763 Octopamine 153.18
BXGC0004965 Rhein 284.22
BXGC0005683 Quercetin 302.24
BXGC0005867 Serotonin 176.22
BXGC0006107 alpha-Linolenic acid 278.43
BXGC0006108 1H-Imidazole-4(5)-acetic acid 126.11
BXGC0006162 L-Glutamic acid 147.13
BXGC0006193 Ellagic acid 302.19
BXGC0006306 Myricetin 318.24
BXGC0006326 Imperatorin 270.28
BXGC0006389 Rotenone 394.42
BXGC0007014 Harman 182.22
BXGC0007029 Emodin 270.24
BXGC0007162 N-Methyl-1-deoxynojirimycin 177.2
BXGC0008184 Phloretin 274.27
BXGC0009318 Nb-Methylserotonin 190.24
BXGC0011182 xi-5-Hydroxydecanoic acid 188.26
BXGC0012352 Chelerythrine 348.12
BXGC0013612 Etofylline 224.09
BXGC0013854 Histamine 111.08
BXGC0014649 4',7-Dimethoxy-5-Hydroxygenistein 298.08
BXGC0014659 D-Alanine 89.05
BXGC0014782 Icosapent 302.22
BXGC0015497 D-phenylalanine 165.08
BXGC0016421 punicalin 782.06
BXGC0016470 Camptothecin 348.11
BXGC0016681 Hispidin 246.05
BXGC0016886 Papaverine Hydrochloride 339.15
BXGC0017277 Aurin 290.09
BXGC0017757 Androstenedione 286.19
BXGC0019091 D-Tryptophan 204.09
BXGC0019664 D-Asparagine 132.05
BXGC0019792 Dihomo-Gamma-Linolenic Acid 306.26
BXGC0020737 Protoapigenone 286.05
BXGC0020756 4-(1,3-Benzothiazol-2-Yl)-2-Methylaniline 240.07
BXGC0020943 D-Leucine 131.09
BXGC0021134 (S)(+)Carvone 150.1
BXGC0022121 Methionine 149.05
BXGC0022544 Digoxin 780.43
BXGC0022677 (9Z,11E)-13-Oxooctadeca-9,11-Dienoic Acid 294.22
BXGC0023640 Lycorine 287.12
BXGC0024261 Adenosine Phosphate 347.06
BXGC0024667 D-Tyrosine 181.07
BXGC0024988 Nifedipine 346.12
BXGC0025386 Gitoxin 780.43
BXGC0025757 Calcimycin 523.27
BXGC0025887 5-Hydroxyflavone 238.06
BXGC0026627 Gingerol 294.18
BXGC0027312 Norarmepavine 299.15
BXGC0027374 Glyburide 493.14
BXGC0027421 Paclitaxel 853.33
BXGC0027462 Damnacanthal 282.05
BXGC0028001 Beta-Lapachone 242.09
BXGC0029355 Pregnenolone 316.24
BXGC0029721 Sclerotiorin 390.12
BXGC0029995 Retinyl Acetate 328.24
BXGC0030028 (D)-Serine 105.04
BXGC0030197 Prostaglandin B1 336.23
BXGC0031363 prostaglandin B2 334.21
BXGC0032911 1,3,4,5,6-Pentahydroxyhexan-2-One 180.06
BXGC0033112 Acetylcysteine 163.03
BXGC0034256 Rottlerin 516.18
BXGC0035226 Betulinic Acid 456.36
BXGC0036441 Quisqualate 189.04
BXGC0036681 7,11B-Dihydro-6H-Indeno[2,1-C]Chromene-3,6A,9,10-Tetrol 286.08
BXGC0036860 Helenalin 262.12
BXGC0037599 Tanshinone Iia 294.13
BXGC0037718 Ethacrynic Acid 302.01
BXGC0038083 Daphnorin 514.11
BXGC0038641 Arundine 246.12
BXGC0040305 Indirubin 262.07
BXGC0041240 Atenolol 266.16
BXGC0042091 Dequalinium 456.33
BXGC0042414 2-[(E)-2-Phenylethenyl]-2,3-Dihydropyran-6-One 200.08
BXGC0042510 Fluoxetine 309.13
BXGC0042870 Piceatannol 244.07
BXGC0043125 Taxifolin 304.06
BXGC0043373 parthenolide 248.14
BXGC0044017 Verapamil 454.28
BXGC0044256 37497-84-0 203.06
BXGC0044812 Sid14737105 261.14
BXGC0044857 Sp-600125 220.06
BXGC0045132 n.a 616.4
BXGC0045746 Diphenyleneiodonium 278.97
BXGC0045812 Trifluoperazine 407.16
BXGC0046510 Tpck 351.07
BXGC0046559 Paraxanthine 180.06
BXGC0046755 Yohimbine 354.19
BXGC0046996 Thioguanine 167.03
BXGC0047334 (2R)-2-Amino-3-Methylselanylpropanoic Acid 182.98
BXGC0047405 Gamolenic Acid 278.22
BXGC0048379 camptothecin 348.11
BXGC0048939 Cotinine 176.09
BXGC0049371 Coronaric acid 296.24
BXGC0049633 4-Aminophenol 109.05
BXGC0049661 Docosapentaenoic Acid 330.26
BXGC0049738 Dexibuprofen 206.13
BXGC0049858 Chalcone 208.09
BXGC0050651 Cryptotanshinone 296.14
BXGC0050823 Chebulinic acid 956.11
BXGC0052374 Reserpine 608.27
BXGC0052646 Tubocurarine 609.3
BXGC0053629 Esatenolol 266.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein