Showing entry for 2-Hydroxychalcone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0018032
Compound Name2-Hydroxychalcone
Structure
FormulaC15H12O2
InchiKeyUDOOPSJCRMKSGL-ZHACJKMWSA-N
SMILESO=C(c1ccccc1)/C=C/c1ccccc1O
InchiInChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)10-11-15(17)12-6-2-1-3-7-12/h1-11,16H/b11-10+
IUPAC(E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
Molecular Weight224.08
Pubchem Id5367146
Chembl IdCHEMBL147067
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 86002
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT011200 Beta-secretase 1 reviewed Enzyme BACE1 - >6.0e+4 - -
reviewed BXGT006430 Cholinesterase reviewed BCHE - 105000 - -
CHEMBL CHEMBL147067
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 28183 nM
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 11220 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 22387 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH IC50 - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 16360 nM
P06276 BXGT006430 Cholinesterase reviewed - BCHE IC50 '=' 105000 nM
P16098 BXGT008191 Beta-amylase reviewed - BMY1 Activity - - -
P06278 BXGT006431 Alpha-amylase reviewed - amyS Activity - - -
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 50118 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 29092 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 31622 nM
P47199 BXGT010568 Quinone oxidoreductase reviewed - Cryz CD '=' 12 uM
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 35481 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 14581 nM
Q77YF9 BXGT016886 Protein Vpr unreviewed - vpr Potency - 44668 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH IC50 '=' 145000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF02852 Sophora flavescens Sophora flavescens Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease