acompound

General Compound Information
BXGC Id	BXGC0023640
Compound Name	Lycorine
Structure
Formula	C16H17NO4
InchiKey	XGVJWXAYKUHDOO-DANNLKNASA-N
SMILES	O[C@H]1C=C2CCN3[C@H]2[C@@H]([C@@H]1O)c1cc2OCOc2cc1C3
Inchi	InChI=1S/C16H17NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h3-5,11,14-16,18-19H,1-2,6-7H2/t11-,14-,15+,16+/m0/s1
IUPAC
Molecular Weight	287.12
Pubchem Id	72378
Chembl Id	CHEMBL400092

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT011959	Cholinesterase	reviewed		BCHE	-	>200000	-	-
reviewed	BXGT004559	Acetylcholinesterase	reviewed		ache	-	>200000	-	-
reviewed	BXGT008751	Acetylcholinesterase	reviewed	Enzyme	ACHE	-	155000	-	-

CHEMBL

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P11387	BXGT007696	DNA topoisomerase 1	reviewed	Enzyme	TOP1	Inhibition	-	-	-
P08684	BXGT006812	Cytochrome P450 3A4	reviewed	Enzyme	CYP3A4	Ki	-	-	-
Q96KQ7	BXGT019687	Histone-lysine N-methyltransferase EHMT2	reviewed	Epigenetic regulator	EHMT2	Potency	-	10000	nM
Q9Y6L6	BXGT022334	Solute carrier organic anion transporter family member 1B1	reviewed	Transporter	SLCO1B1	Inhibition	'='	60	%
P49798	BXGT010745	Regulator of G-protein signaling 4	reviewed	Enzyme modulator	RGS4	Potency	-	4744	nM
P22303	BXGT008751	Acetylcholinesterase	reviewed	Enzyme	ACHE	Ki	-	-	-
P11388	BXGT007697	DNA topoisomerase 2-alpha	reviewed	-	TOP2A	Inhibition	-	-	-
P22303	BXGT008751	Acetylcholinesterase	reviewed	Enzyme	ACHE	IC50	'='	155000	nM
Q16637	BXGT013646	Survival motor neuron protein	reviewed	Epigenetic regulator	SMN1	Potency	'='	1122	nM
Q9NPD5	BXGT021151	Solute carrier organic anion transporter family member 1B3	reviewed	Transporter	SLCO1B3	Inhibition	'='	97	%
O42275	BXGT004559	Acetylcholinesterase	reviewed	-	ache	IC50	'>'	200000	nM
P81908	BXGT011959	Cholinesterase	reviewed	-	BCHE	IC50	'>'	200000	nM
P22303	BXGT008751	Acetylcholinesterase	reviewed	Enzyme	ACHE	IC50	'>'	200000	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF01458	Ligularia altaica	Ligularia altaica	Others
BXGF01558	Ferula persica	Ferula persica	Medicinal Plant
BXGF01666	Helichrysum asperum	Helichrysum asperum	Medicinal Plant
BXGF01703	Dalbergia candenatensis	Dalbergia candenatensis	Medicinal Plant
BXGF02466	Ligularia przewalskii	Ligularia przewalskii	Others
BXGF02651	Searsia leptodictya	Searsia leptodictya	Human Edible Plant
BXGF02696	Lophopetalum toxicum	Lophopetalum toxicum	Others
BXGF02919	Stachys aegyptiaca	Stachys aegyptiaca	Others
BXGF03032	Anthoceros punctatus	Anthoceros punctatus	Others
BXGF03266	Elaeocarpus sphaericus	Elaeocarpus sphaericus	Human Edible Plant
BXGF03372	Lupinus holosericeus	Lupinus holosericeus	Others
BXGF03385	Cinchona officinalis	Cinchona officinalis	Medicinal Plant
BXGF03409	Datura wrightii	Datura wrightii	Others
BXGF03585	Angelica hirsutiflora	Angelica hirsutiflora	Others
BXGF03595	Clausena suffruticosa	Clausena suffruticosa	Others
BXGF03617	Crinum yemense	Crinum yemense	Others
BXGF05066	amaryllidaceae	amaryllidaceae	Others
BXGF05299	Corynandra viscosa	Corynandra viscosa	Medicinal Plant
BXGF06260	Dryopteris dilatata	Dryopteris dilatata	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}