Showing entry for DNA topoisomerase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007696
Protein NameDNA topoisomerase 1
Uniport IdP11387
GeneTOP1
Gene Id7150
DomainTopoisom_I; Topoisom_I_N; Topo_C_assoc
Pfam PF14370   PF01028   PF02919  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0007059 chromosome segregation
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0007623 circadian rhythm
Biological Process GO:0006260 DNA replication
Biological Process GO:0006265 DNA topological change
Biological Process GO:0040016 embryonic cleavage
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0016310 phosphorylation
Biological Process GO:0012501 programmed cell death
Biological Process GO:0042493 response to drug
Biological Process GO:0016032 viral process
molecular function GO:0005524 ATP binding
molecular function GO:0003682 chromatin binding
molecular function GO:0003677 DNA binding
molecular function GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
molecular function GO:0003690 double-stranded DNA binding
molecular function GO:0019904 protein domain specific binding
molecular function GO:0004674 protein serine/threonine kinase activity
molecular function GO:0003723 RNA binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0003697 single-stranded DNA binding
molecular function GO:0097100 supercoiled DNA binding
cellular component GO:0001650 fibrillar center
cellular component GO:0005730 nucleolus
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0000932 P-body
cellular component GO:0043204 perikaryon
cellular component GO:0032993 protein-DNA complex
cellular component GO:0031298 replication fork protection complex
Reactome
Pathway Id Pathway Name
R-HSA-2990846 SUMOylation
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-392499 Metabolism of proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004135 BXGD000257 Ataxia Telangiectasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0004138 BXGD000258 Ataxias, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004930 BXGD000294 Behavior Disorders Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005890 BXGD000345 Body Height
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007140 BXGD000447 Carcinosarcoma Neoplasms
C0007758 BXGD000475 Cerebellar Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0013221 BXGD000804 Drug toxicity Chemically-Induced Disorders
C0014772 BXGD000948 Red Blood Cell Count measurement
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015625 BXGD001006 Fanconi Anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0016057 BXGD001042 Fibrosarcoma Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023530 BXGD001683 Leukopenia Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0027947 BXGD002061 Neutropenia Hemic and Lymphatic Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0030499 BXGD002232 Parasitic Diseases Infections
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0041755 BXGD002933 Adverse reaction to drug Chemically-Induced Disorders
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086692 BXGD003306 Benign Neoplasm Neoplasms
C0087012 BXGD003318 Ataxia, Spinocerebellar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0162635 BXGD003964 Angelman Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202239 BXGD004087 Uric acid measurement (procedure)
C0205682 BXGD004105 Waist-Hip Ratio
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0206720 BXGD004266 Squamous Cell Neoplasms Neoplasms
C0206727 BXGD004272 Nerve Sheath Tumors Neoplasms; Nervous System Diseases
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0235874 BXGD004781 Disease Exacerbation Pathological Conditions, Signs and Symptoms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0262404 BXGD005236 Cerebellar degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0265987 BXGD005598 Nevus comedonicus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases
C0270921 BXGD006133 Axonal neuropathy Nervous System Diseases
C0278488 BXGD006515 Carcinoma breast stage IV
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278595 BXGD006545 Adult Fibrosarcoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0279646 BXGD006670 Childhood Acute Monocytic Leukemia Neoplasms
C0280255 BXGD006729 stage, endometrial carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280634 BXGD006753 Adult Acute Monocytic Leukemia Neoplasms
C0282687 BXGD006826 Hemorrhagic Fever, Ebola Infections
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0428568 BXGD008633 Fasting blood glucose measurement
C0478658 BXGD009015 Disorder of psychological development Mental Disorders
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0596887 BXGD009648 mathematical ability
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677949 BXGD009740 Stage III Colorectal Cancer Digestive System Diseases; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0858252 BXGD011172 Breast adenocarcinoma Neoplasms; Skin and Connective Tissue Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1258104 BXGD011823 Diffuse Scleroderma Skin and Connective Tissue Diseases
C1261430 BXGD011853 Fasting blood sugar result
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1318544 BXGD012401 M5b Acute differentiated monocytic leukemia Neoplasms; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1336735 BXGD012856 Treatment related acute myeloid leukaemia
C1445957 BXGD013081 Serum total cholesterol measurement
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1846574 BXGD014830 SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE, WITH AXONAL NEUROPATHY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1859598 BXGD015913 ATAXIA, EARLY-ONSET, WITH OCULOMOTOR APRAXIA AND HYPOALBUMINEMIA Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Hemic and Lymphatic Diseases; Behavior and Behavior Mechanisms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2364016 BXGD017122 Systemic sclerosis [scleroderma]
C3146250 BXGD018259 Stage III Colorectal Cancer AJCC v7
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3469521 BXGD018910 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C3714514 BXGD019409 Infection Infections
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4016020 BXGD020258 DNA TOPOISOMERASE I, CAMPTOTHECIN-RESISTANT
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4275170 BXGD022367 Autosomal recessive cerebellar ataxia with oculomotor apraxia type 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases; Behavior and Behavior Mechanisms; Cardiovascular Diseases
C4525546 BXGD023141 Chicken Lymphoma
C4721579 BXGD023759 Secondary malignant neoplasm of colon and/or rectum Digestive System Diseases; Neoplasms
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4733095 BXGD023910 HER2-negative breast cancer
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000051 Kaempferol 3-O-(2''-rhamnosyl-galactoside) 7-O-rhamnoside 740.66
BXGC0000116 1,4-Naphtoquinone 158.15
BXGC0000332 Fisetin 286.24
BXGC0000952 6-Oxocamphor 457.91
BXGC0001899 Daidzein 254.24
BXGC0001991 Juglone 174.15
BXGC0002195 Elaidic acid 282.46
BXGC0003487 Plumbagin 188.18
BXGC0003601 Momordin B 632.84
BXGC0003772 Corilagin 634.45
BXGC0005513 Hexadecanoic acid 256.42
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0006306 Myricetin 318.24
BXGC0006466 Oleanolic acid 456.71
BXGC0006635 Luteolin 286.24
BXGC0007668 (+)-Syringaresinol 418.44
BXGC0013582 Curcumin 368.13
BXGC0013775 Alkannin 288.1
BXGC0014616 Astragalin 7-rhamnoside 594.16
BXGC0015010 Chebulagic Acid 954.1
BXGC0015147 ginsenoside Rg3 784.5
BXGC0016470 Camptothecin 348.11
BXGC0016675 ginsenoside F3 770.48
BXGC0017248 Evodiamine 303.14
BXGC0017541 Mansonone F 240.08
BXGC0018046 evodiamine 303.14
BXGC0018095 Danthron methyl derivative 254.06
BXGC0018265 alpha-Deoxycamptothecin 332.12
BXGC0019142 ginsenoside Rb3 1078.59
BXGC0019143 Nitidine Chloride 348.12
BXGC0019460 Hydroxycamptothecin 364.11
BXGC0021319 20(S)-Ginsenoside Rg2 784.5
BXGC0021588 Damara-20(22), 24-dien-3, 6, 12-trine 458.38
BXGC0023195 Betulin 442.38
BXGC0023640 Lycorine 287.12
BXGC0024198 oleanderolide 472.36
BXGC0024814 20(R)-Ginsenoside Rg2 784.5
BXGC0024823 dicentrinone 335.08
BXGC0025215 Lupeol 426.39
BXGC0025231 Betunolic Acid 454.34
BXGC0025602 Beta-Amyrin Acetate 468.4
BXGC0025793 24-hydroxy-beta-amyrin 442.38
BXGC0027259 Tryptanthrin 248.06
BXGC0027406 ginsenoside Rd 946.55
BXGC0027430 ginsenoside Re 946.55
BXGC0027438 ginsenoside Rb1 1108.6
BXGC0028111 ginsenoside F5 770.48
BXGC0028587 Acetylalkannin 330.11
BXGC0029547 Lycobetaine 266.08
BXGC0029548 Ungeremine 265.07
BXGC0030612 tetraethylene glycol 194.12
BXGC0031119 Trisphaeridine 223.06
BXGC0032049 Isobutylshikonin 358.14
BXGC0032798 Shikonin 288.1
BXGC0032824 Kampferol 3-glucoside 7-rhamnoside 594.16
BXGC0032936 Echinatin 270.09
BXGC0034126 Kaempferol 3-O-Rha(1-2)Glc 7-O-Rha 740.22
BXGC0034166 [(1R)-1-(5,8-Dihydroxy-1,4-Dioxonaphthalen-2-Yl)-4-Methylpent-3-Enyl] Propanoate 344.13
BXGC0034637 Aesculioside Iv-23D1 1124.58
BXGC0034783 Doxorubicin 543.17
BXGC0034894 Oleic Acid 282.26
BXGC0035226 Betulinic Acid 456.36
BXGC0035370 Germanicol 426.39
BXGC0035474 rabdosiin 718.15
BXGC0036649 Quinovic acid 3-O-beta-D-glucoside 648.39
BXGC0036911 kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 564.15
BXGC0037083 Alpha-Amyrin 426.39
BXGC0037313 gypenoside IX 916.54
BXGC0038066 Rescinnamine 634.29
BXGC0039870 Dimethylacrylshikonin 370.14
BXGC0040114 Acetylshikonin 330.11
BXGC0040778 Zygophyloside E 810.44
BXGC0041194 [(1R)-1-(5,8-Dihydroxy-1,4-Dioxonaphthalen-2-Yl)-4-Methylpent-3-Enyl] Butanoate 358.14
BXGC0041449 Degalactotigonin 1034.53
BXGC0041925 O-acetylcamptothecin 390.12
BXGC0042236 ginsenoside F2 784.5
BXGC0044819 Sid4253497 365.11
BXGC0045253 [(1R)-1-(5,8-Dihydroxy-1,4-Dioxonaphthalen-2-Yl)-4-Methylpent-3-Enyl] Pent-4-Enoate 370.14
BXGC0045342 n.a 602.35
BXGC0045343 [acetoxy-tetrahydroxy-(hydroxymethyl)-isopropenyl-dimethyl-oxo-[?]yl] (2E,4E)-trideca-2,4-dienoate 646.34
BXGC0045345 1,3,3aalpha,4,9,9aalpha-Hexahydro-3alpha-(4-hydroxy-3-methoxyphenyl)-7-methoxynaphtho[2,3-c]furan-6-ol 342.15
BXGC0046055 Huratoxin 584.33
BXGC0046133 Plukenetione A 500.29
BXGC0046281 Cucurbitacin B 558.32
BXGC0046519 [(1R)-1-(5,8-dihydroxy-1,4-dioxo-naphthalen-2-yl)-4-methyl-pent-3-enyl] Benzoate 392.13
BXGC0046521 [(1R)-1-(5,8-dihydroxy-1,4-dioxo-naphthalen-2-yl)-4-methyl-pent-3-enyl] Pentanoate 372.16
BXGC0046642 matrine 248.19
BXGC0046755 Yohimbine 354.19
BXGC0047189 oxynitidine 363.11
BXGC0049572 Gypenoside XVII 946.55
BXGC0049906 n.a 606.16
BXGC0051140 20(R)-ginsenoside Rg3 784.5
BXGC0051568 Rabdosiin 718.15
BXGC0052374 Reserpine 608.27
BXGC0053512 Vittatine 271.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein