Showing entry for Aureusidin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0025617
Compound NameAureusidin
Structure
FormulaC15H10O6
InchiKeyWBEFUVAYFSOUEA-PQMHYQBVSA-N
SMILESOc1cc2O/C(=C\c3ccc(c(c3)O)O)/C(=O)c2c(c1)O
InchiInChI=1S/C15H10O6/c16-8-5-11(19)14-12(6-8)21-13(15(14)20)4-7-1-2-9(17)10(18)3-7/h1-6,16-19H/b13-4-
IUPAC(2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-4,6-dihydroxy-1-benzofuran-3-one
Molecular Weight286.05
Pubchem Id5281220
Chembl IdCHEMBL593229
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50439491
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 - 38000 - -
reviewed BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 - 38900 - -
reviewed BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 - 48500 - -
reviewed BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 - 18500 - -
reviewed BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 - 4810 - -
reviewed BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 - 3500 - -
CHEMBL CHEMBL593229
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 Activity '=' -47 %
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 Activity '=' -47 %
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 Activity '=' 0 %
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 Activity '=' 0 %
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 Activity '=' -88 %
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 Activity '=' -88 %
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 IC50 '=' 48500 nM
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 IC50 '=' 38000 nM
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 IC50 '=' 38900 nM
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 IC50 '=' 4810 nM
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 IC50 '=' 4810 nM
Q969S8 BXGT019613 Polyamine deacetylase HDAC10 reviewed Epigenetic regulator HDAC10 IC50 '=' 18500 nM
Q9UKV0 BXGT021750 Histone deacetylase 9 reviewed Epigenetic regulator HDAC9 IC50 '=' 18500 nM
P56524 BXGT011176 Histone deacetylase 4 reviewed Epigenetic regulator HDAC4 IC50 '=' 18500 nM
Q96DB2 BXGT019639 Histone deacetylase 11 reviewed Epigenetic regulator HDAC11 IC50 '=' 18500 nM
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed Epigenetic regulator HDAC8 IC50 '=' 18500 nM
Q8WUI4 BXGT018992 Histone deacetylase 7 reviewed Epigenetic regulator HDAC7 IC50 '=' 18500 nM
Q9UQL6 BXGT021813 Histone deacetylase 5 reviewed Epigenetic regulator HDAC5 IC50 '=' 18500 nM
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 IC50 '=' 18500 nM
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 IC50 '=' 18500 nM
O15379 BXGT004159 Histone deacetylase 3 reviewed Epigenetic regulator HDAC3 IC50 '=' 18500 nM
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 IC50 '=' 18500 nM
Q8IXJ6 BXGT018362 NAD-dependent protein deacetylase sirtuin-2 reviewed Epigenetic regulator SIRT2 Inhibition - - -
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 Activity '=' -20 %
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 Activity '=' -20 %
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 Activity '=' -2 %
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 Activity '=' -2 %
Q969S8 BXGT019613 Polyamine deacetylase HDAC10 reviewed Epigenetic regulator HDAC10 Inhibition '=' 100 %
Q9UKV0 BXGT021750 Histone deacetylase 9 reviewed Epigenetic regulator HDAC9 Inhibition '=' 100 %
P56524 BXGT011176 Histone deacetylase 4 reviewed Epigenetic regulator HDAC4 Inhibition '=' 100 %
Q96DB2 BXGT019639 Histone deacetylase 11 reviewed Epigenetic regulator HDAC11 Inhibition '=' 100 %
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed Epigenetic regulator HDAC8 Inhibition '=' 100 %
Q8WUI4 BXGT018992 Histone deacetylase 7 reviewed Epigenetic regulator HDAC7 Inhibition '=' 100 %
Q9UQL6 BXGT021813 Histone deacetylase 5 reviewed Epigenetic regulator HDAC5 Inhibition '=' 100 %
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 Inhibition '=' 100 %
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 Inhibition '=' 100 %
O15379 BXGT004159 Histone deacetylase 3 reviewed Epigenetic regulator HDAC3 Inhibition '=' 100 %
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 Inhibition '=' 100 %
Q969S8 BXGT019613 Polyamine deacetylase HDAC10 reviewed Epigenetic regulator HDAC10 Inhibition - - -
Q9UKV0 BXGT021750 Histone deacetylase 9 reviewed Epigenetic regulator HDAC9 Inhibition - - -
P56524 BXGT011176 Histone deacetylase 4 reviewed Epigenetic regulator HDAC4 Inhibition - - -
Q96DB2 BXGT019639 Histone deacetylase 11 reviewed Epigenetic regulator HDAC11 Inhibition - - -
Q9BY41 BXGT020180 Histone deacetylase 8 reviewed Epigenetic regulator HDAC8 Inhibition - - -
Q8WUI4 BXGT018992 Histone deacetylase 7 reviewed Epigenetic regulator HDAC7 Inhibition - - -
Q9UQL6 BXGT021813 Histone deacetylase 5 reviewed Epigenetic regulator HDAC5 Inhibition - - -
Q92769 BXGT019370 Histone deacetylase 2 reviewed Epigenetic regulator HDAC2 Inhibition - - -
Q9UBN7 BXGT021658 Histone deacetylase 6 reviewed Epigenetic regulator HDAC6 Inhibition - - -
O15379 BXGT004159 Histone deacetylase 3 reviewed Epigenetic regulator HDAC3 Inhibition - - -
Q13547 BXGT013373 Histone deacetylase 1 reviewed Epigenetic regulator HDAC1 Inhibition - - -
P10826 BXGT007622 Retinoic acid receptor beta reviewed Nuclear receptor RARB Inhibition - - -
Q15078 BXGT013534 Cyclin-dependent kinase 5 activator 1 reviewed Enzyme modulator CDK5R1 IC50 '=' 3500 nM
Q00535 BXGT012534 Cyclin-dependent-like kinase 5 reviewed Kinase CDK5 IC50 '=' 3500 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00054 Lemon Citrus limon Fruits
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease