Showing entry for Histone deacetylase 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021813
Protein NameHistone deacetylase 5
Uniport IdQ9UQL6
GeneHDAC5
Gene Id10014
DomainHDAC4_Gln; Hist_deacetyl
Pfam PF12203   PF00850  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04371 Apelin signaling pathway
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0042113 B cell activation
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006342 chromatin silencing
Biological Process GO:0016575 histone deacetylation
Biological Process GO:0006954 inflammatory response
Biological Process GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
Biological Process GO:0010832 negative regulation of myotube differentiation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0051091 positive regulation of DNA-binding transcription factor activity
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006476 protein deacetylation
Biological Process GO:0040029 regulation of gene expression, epigenetic
Biological Process GO:0010830 regulation of myotube differentiation
Biological Process GO:0043393 regulation of protein binding
Biological Process GO:0014823 response to activity
Biological Process GO:0042220 response to cocaine
Biological Process GO:0042493 response to drug
molecular function GO:0003682 chromatin binding
molecular function GO:0004407 histone deacetylase activity
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0042802 identical protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
molecular function GO:0033558 protein deacetylase activity
molecular function GO:0005080 protein kinase C binding
molecular function GO:0070491 repressing transcription factor binding
molecular function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function GO:0001085 RNA polymerase II transcription factor binding
molecular function GO:0008134 transcription factor binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005794 Golgi apparatus
cellular component GO:0000118 histone deacetylase complex
cellular component GO:0016607 nuclear speck
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-1980143 Signaling by NOTCH1
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-212436 Generic Transcription Pathway
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603 Signaling by NOTCH1 in Cancer
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-6807070 PTEN Regulation
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-9006925 Intracellular signaling by second messengers
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001546 BXGD000060 Adjustment Disorders Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0003486 BXGD000197 Aortic Aneurysm Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0005587 BXGD000316 Depression, Bipolar Mental Disorders
C0005938 BXGD000351 Bone Density
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0009171 BXGD000587 Cocaine Abuse Chemically-Induced Disorders; Mental Disorders
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011579 BXGD000732 Reactive depression Mental Disorders
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011644 BXGD000744 Scleroderma Skin and Connective Tissue Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020542 BXGD001425 Pulmonary Hypertension Respiratory Tract Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024713 BXGD001799 Manic Disorder Mental Disorders
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0026936 BXGD001950 Mycoplasma Infections Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027708 BXGD002025 Nephroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0032302 BXGD002347 Mycoplasma pneumonia Infections; Respiratory Tract Diseases
C0036220 BXGD002587 Kaposi Sarcoma Neoplasms; Infections
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0038443 BXGD002757 Stress, Psychological Behavior and Behavior Mechanisms
C0041671 BXGD002930 Attention Deficit Disorder Mental Disorders
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0042373 BXGD002978 Vascular Diseases Cardiovascular Diseases
C0085413 BXGD003171 Polycystic Kidney, Autosomal Dominant Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0162770 BXGD003980 Right Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162835 BXGD003989 Hypopigmentation disorder Skin and Connective Tissue Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0202236 BXGD004086 Triglycerides measurement
C0206655 BXGD004218 Alveolar rhabdomyosarcoma Neoplasms
C0206663 BXGD004225 Neuroectodermal Tumor, Primitive Neoplasms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0236736 BXGD004825 Cocaine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278876 BXGD006607 Adult Medulloblastoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0333983 BXGD006975 Hyperplastic Polyp Pathological Conditions, Signs and Symptoms
C0338831 BXGD007216 Manic Mental Disorders
C0340543 BXGD007344 Familial primary pulmonary hypertension Respiratory Tract Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0410438 BXGD008427 Primary osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600427 BXGD009706 Cocaine Dependence Chemically-Induced Disorders; Mental Disorders
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0684337 BXGD009796 Ewings sarcoma-primitive neuroectodermal tumor (PNET) Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0740392 BXGD009988 Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0871388 BXGD011314 social stress Behavior and Behavior Mechanisms
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1333015 BXGD012581 Childhood Kidney Wilms Tumor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1522512 BXGD013255 Transient Situational Disturbance Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1876214 BXGD016567 ALBINOIDISM, OCULOCUTANEOUS, AUTOSOMAL DOMINANT Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Skin and Connective Tissue Diseases
C1969342 BXGD016771 PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED Respiratory Tract Diseases
C1969343 BXGD016772 Pulmonary Hypertension, Primary, Fenfluramine-Associated Respiratory Tract Diseases
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2609414 BXGD017182 Acute kidney injury Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C3203102 BXGD018555 Idiopathic pulmonary arterial hypertension Respiratory Tract Diseases
C3496069 BXGD019017 cocaine use
C3554225 BXGD019205 LEPTIN RECEPTOR DEFICIENCY
C3714844 BXGD019435 Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia Respiratory Tract Diseases
C3887499 BXGD019884 Renal cyst Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4552070 BXGD023481 Pulmonary Hypertension, Primary, 1 Respiratory Tract Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000076 p-Coumaroyl tartaric acid glucosidic ester 150.09
BXGC0000099 3,4-Dihydroxyphenylacetic acid 168.15
BXGC0000504 Vanillic acid 168.15
BXGC0000528 Salicylic acid 138.12
BXGC0000539 Anthranilic acid 137.14
BXGC0000843 3-Methylbutanoic acid 102.13
BXGC0001273 Hippuric acid 179.17
BXGC0001380 Succinic acid 118.09
BXGC0001545 Harmine 212.25
BXGC0001857 Caffeic acid 180.16
BXGC0001860 Neochlorogenic acid 354.31
BXGC0001879 Chlorogenic acid 354.31
BXGC0001887 m-Coumaric acid 164.16
BXGC0001918 3,5-Di-O-caffeoylquinic acid 516.45
BXGC0002244 Doconexent 328.49
BXGC0002394 Pentanoic acid 102.13
BXGC0002427 2-Methylpropanoic acid 88.11
BXGC0003205 (+)-Valine 117.15
BXGC0004269 Propanoic acid 74.08
BXGC0004588 trans-Cinnamic acid 148.16
BXGC0004647 3-(3,4-Dihydroxyphenyl)propanoic acid 182.17
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0005796 Butanoic acid 88.11
BXGC0005898 2,3-Dihydroxybenzoic acid 154.12
BXGC0005982 Curcumin 368.38
BXGC0006198 Citric acid 192.12
BXGC0006366 trans-Ferulic acid 194.18
BXGC0007028 beta-Thujaplicin 164.2
BXGC0013582 Curcumin 368.13
BXGC0013952 (2Z)-2-[(4-Chlorophenyl)Methylidene]-1-Benzofuran-3-One 256.03
BXGC0014602 Kojic Acid 142.03
BXGC0020680 Mandelic Acid 152.05
BXGC0023330 Methylconiferylaldehyde 192.08
BXGC0025617 Aureusidin 286.05
BXGC0026480 Osajin 404.16
BXGC0033112 Acetylcysteine 163.03
BXGC0034421 n.a 530.14
BXGC0034778 Artemisinin 282.15
BXGC0034783 Doxorubicin 543.17
BXGC0037070 Epicoccolide B 358.07
BXGC0037722 Pomiferin 420.16
BXGC0042127 Oxyquinoline 145.05
BXGC0042413 Calcitriol 416.33
BXGC0046518 Chloroquine 319.18
BXGC0047088 Ursolic Acid 456.36
BXGC0047529 2-hydroxybutyric acid 104.05
BXGC0047692 Gefitinib 446.15
BXGC0048689 Sorbic Acid 112.05
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein