Showing entry for Histone deacetylase 8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020180
Protein NameHistone deacetylase 8
Uniport IdQ9BY41
GeneHDAC8
Gene Id55869
DomainHist_deacetyl
Pfam PF00850  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
6. Human Diseases 6.5 Substance dependence hsa05034 Alcoholism
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006333 chromatin assembly or disassembly
Biological Process GO:0006325 chromatin organization
Biological Process GO:0070932 histone H3 deacetylation
Biological Process GO:0070933 histone H4 deacetylation
Biological Process GO:0031397 negative regulation of protein ubiquitination
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0071922 regulation of cohesin loading
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0032204 regulation of telomere maintenance
Biological Process GO:0007062 sister chromatid cohesion
molecular function GO:0004407 histone deacetylase activity
molecular function GO:0030544 Hsp70 protein binding
molecular function GO:0051879 Hsp90 protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
molecular function GO:0008134 transcription factor binding
cellular component GO:0005737 cytoplasm
cellular component GO:0000118 histone deacetylase complex
cellular component GO:0000228 nuclear chromosome
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-1980143 Signaling by NOTCH1
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-212436 Generic Transcription Pathway
R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603 Signaling by NOTCH1 in Cancer
R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-3214815 HDACs deacetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-4839726 Chromatin organization
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0001144 BXGD000028 Acne Vulgaris Skin and Connective Tissue Diseases
C0003466 BXGD000193 Anus, Imperforate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005741 BXGD000328 Blepharitis Eye Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008297 BXGD000522 Choanal Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018418 BXGD001192 Gynecomastia Skin and Connective Tissue Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018800 BXGD001225 Cardiomegaly Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018817 BXGD001235 Atrial Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0018818 BXGD001236 Ventricular Septal Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019572 BXGD001338 Hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020534 BXGD001421 Orbital separation excessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020545 BXGD001427 Hypertension, Renovascular Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0022680 BXGD001576 Polycystic Kidney Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023267 BXGD001626 Fibroid Tumor Neoplasms
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0025995 BXGD001885 Micromelia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027022 BXGD001962 Myeloproliferative disease Hemic and Lymphatic Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027960 BXGD002062 Nevus Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030499 BXGD002232 Parasitic Diseases Infections
C0032339 BXGD002352 Rothmund-Thomson syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0033027 BXGD002388 Preleukemia Neoplasms; Hemic and Lymphatic Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0034012 BXGD002449 Delayed Puberty Endocrine System Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0034194 BXGD002472 Pyloric Stenosis Digestive System Diseases
C0035372 BXGD002544 Rett Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0036323 BXGD002595 Schistosomiasis Infections
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037822 BXGD002706 Speech Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0039273 BXGD002806 Talipes cavus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0042133 BXGD002960 Uterine Fibroids Neoplasms
C0042580 BXGD002992 Vesico-Ureteral Reflux Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042961 BXGD003017 Intestinal Volvulus Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0078981 BXGD003059 Arachnoid Cysts Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079773 BXGD003100 Lymphoma, T-Cell, Cutaneous Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085633 BXGD003216 Mood swings Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0086543 BXGD003294 Cataract Eye Diseases
C0151526 BXGD003432 Premature Birth Female Urogenital Diseases and Pregnancy Complications
C0152421 BXGD003586 Macrotia
C0152423 BXGD003587 Congenital small ears Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Otorhinolaryngologic Diseases
C0154536 BXGD003719 Amphetamine or related acting sympathomimetic abuse Chemically-Induced Disorders; Mental Disorders
C0158761 BXGD003905 Radioulnar Synostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0221210 BXGD004406 Congenital malrotation of intestine Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0221356 BXGD004448 Brachycephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0232939 BXGD004568 Primary physiologic amenorrhea Pathological Conditions, Signs and Symptoms
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235833 BXGD004775 Congenital diaphragmatic hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0239174 BXGD004969 Late tooth eruption
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0241355 BXGD005092 Small testicle
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0259779 BXGD005218 Fibrous Dysplasia
C0263401 BXGD005298 Cutis marmorata Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Skin and Connective Tissue Diseases; Cardiovascular Diseases; Wounds and Injuries
C0265660 BXGD005561 Syndactyly of the toes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0266011 BXGD005605 Accessory nipple Skin and Connective Tissue Diseases
C0266383 BXGD005660 Uterine Anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0266544 BXGD005691 Microcornea Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0268790 BXGD006039 Renal vascular disorder Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Cardiovascular Diseases
C0270972 BXGD006147 Cornelia De Lange Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0271007 BXGD006152 Phthisis bulbi Pathological Conditions, Signs and Symptoms; Eye Diseases
C0271623 BXGD006222 Hypogonadotropic hypogonadism Endocrine System Diseases
C0278701 BXGD006566 Gastric Adenocarcinoma Digestive System Diseases; Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0349588 BXGD007933 Short stature
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0423113 BXGD008473 Telecanthus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0426429 BXGD008564 Broad nasal tip
C0426886 BXGD008594 Tapering fingers (finding)
C0431447 BXGD008690 Synophrys Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0432072 BXGD008718 Dysmorphic features
C0432355 BXGD008780 Hypoplasia of nipple
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0497406 BXGD009064 Overweight Pathological Conditions, Signs and Symptoms
C0521525 BXGD009139 Short neck
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0541764 BXGD009259 Delayed bone age
C0557874 BXGD009444 Global developmental delay
C0566899 BXGD009494 Small labia majora
C0575802 BXGD009521 Small hand
C0576226 BXGD009527 Short foot
C0578038 BXGD009542 Thin lips
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600104 BXGD009690 Obsessive compulsive behavior Behavior and Behavior Mechanisms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0702166 BXGD009912 Acne Skin and Connective Tissue Diseases
C0728895 BXGD009919 Absent finger Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0751690 BXGD010553 Malignant Peripheral Nerve Sheath Tumor Neoplasms; Nervous System Diseases
C0848558 BXGD010882 Hypospadias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0854917 BXGD011050 Rhabdoid Tumor of the Kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0919747 BXGD011439 Cytokine storm
C1135161 BXGD011690 Stage 4S neuroblastoma
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1301937 BXGD012300 Talipes Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1302790 BXGD012313 Congenital malformation syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1328407 BXGD012465 Hip Dysplasia Musculoskeletal Diseases; Wounds and Injuries
C1386048 BXGD012950 Intrauterine retardation
C1387005 BXGD012953 Penis agenesis Male Urogenital Diseases
C1389018 BXGD012963 Atrioventricular Septal Defect Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1565489 BXGD013401 Renal Insufficiency Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1839736 BXGD014399 WILSON-TURNER X-LINKED MENTAL RETARDATION SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases
C1840077 BXGD014434 Anteverted nostril
C1842060 BXGD014491 Prominent supraorbital ridges
C1842366 BXGD014512 Low anterior hairline
C1842878 BXGD014543 Short 5th finger
C1843367 BXGD014576 Poor school performance
C1844813 BXGD014679 Widely spaced teeth
C1847879 BXGD014895 X-linked dominant inheritance
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1848673 BXGD014963 Hypoplastic feet
C1849211 BXGD015023 Generalized hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1849311 BXGD015034 Short 1st metacarpal
C1849510 BXGD015061 Prenatal movement abnormality
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1853487 BXGD015340 Thick eyebrow
C1853738 BXGD015357 Long eyelashes
C1854113 BXGD015382 Prominent nasal bridge
C1854114 BXGD015383 Short nose
C1855728 BXGD015536 Low posterior hairline
C1856115 BXGD015574 Happy demeanor
C1857042 BXGD015669 Sparse scalp hair
C1857486 BXGD015710 Low-set, posteriorly rotated ears
C1857641 BXGD015727 Severe postnatal growth retardation
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858732 BXGD015826 Malar prominence
C1859778 BXGD015931 Postnatal growth retardation
C1861403 BXGD016045 Variable expressivity
C1862095 BXGD016100 Bilateral single transverse palmar creases
C1865014 BXGD016282 Long philtrum
C1865017 BXGD016283 Thin upper lip vermilion
C1865572 BXGD016331 Proximal placement of thumb
C1866190 BXGD016384 Atresia of the external auditory canal
C1866195 BXGD016385 Downturned corners of mouth
C1867103 BXGD016438 Limited elbow extension
C1868571 BXGD016508 Highly arched eyebrow
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2145472 BXGD016931 Urothelial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2673670 BXGD017220 Curly eyelashes
C2674608 BXGD017250 Feeding difficulties in infancy
C2919142 BXGD017867 Short Stature, CTCAE
C2986665 BXGD018237 Early-Stage Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3278923 BXGD018748 Dilated ventricles (finding)
C3279222 BXGD018751 Aplasia/Hypoplasia of the cerebellum
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3494422 BXGD018966 Retrognathia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3550903 BXGD019141 CORNELIA DE LANGE SYNDROME 5
C3714581 BXGD019415 Multicystic Dysplastic Kidney Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887496 BXGD019882 Oligodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4020740 BXGD020476 Clinodactyly of the 4th toe
C4023676 BXGD021237 Increased nuchal translucency Pathological Conditions, Signs and Symptoms
C4023731 BXGD021255 4-5 finger syndactyly
C4023915 BXGD021274 Abnormally low-pitched voice
C4025741 BXGD021770 Clinodactyly of the 5th toe
C4025790 BXGD021791 Specific learning disability
C4025871 BXGD021839 Abnormality of the face
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4317146 BXGD022730 Acid reflux
C4551560 BXGD023349 Truncal obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C4551563 BXGD023351 Microcephaly (physical finding)
C4551583 BXGD023361 Cerebral cortical atrophy
C4551851 BXGD023419 Cornelia de Lange Syndrome 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000076 p-Coumaroyl tartaric acid glucosidic ester 150.09
BXGC0000099 3,4-Dihydroxyphenylacetic acid 168.15
BXGC0000253 Glycylglycylglycine 189.17
BXGC0000436 Glycerol 92.09
BXGC0000504 Vanillic acid 168.15
BXGC0000528 Salicylic acid 138.12
BXGC0000539 Anthranilic acid 137.14
BXGC0000843 3-Methylbutanoic acid 102.13
BXGC0001273 Hippuric acid 179.17
BXGC0001380 Succinic acid 118.09
BXGC0001545 Harmine 212.25
BXGC0001857 Caffeic acid 180.16
BXGC0001860 Neochlorogenic acid 354.31
BXGC0001879 Chlorogenic acid 354.31
BXGC0001887 m-Coumaric acid 164.16
BXGC0001918 3,5-Di-O-caffeoylquinic acid 516.45
BXGC0002244 Doconexent 328.49
BXGC0002394 Pentanoic acid 102.13
BXGC0002427 2-Methylpropanoic acid 88.11
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0002591 Potassium 39.1
BXGC0002682 Zinc 65.41
BXGC0003205 (+)-Valine 117.15
BXGC0004269 Propanoic acid 74.08
BXGC0004588 trans-Cinnamic acid 148.16
BXGC0004647 3-(3,4-Dihydroxyphenyl)propanoic acid 182.17
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0005796 Butanoic acid 88.11
BXGC0005898 2,3-Dihydroxybenzoic acid 154.12
BXGC0005982 Curcumin 368.38
BXGC0006198 Citric acid 192.12
BXGC0006366 trans-Ferulic acid 194.18
BXGC0007028 beta-Thujaplicin 164.2
BXGC0008661 Iron 55.85
BXGC0013582 Curcumin 368.13
BXGC0013952 (2Z)-2-[(4-Chlorophenyl)Methylidene]-1-Benzofuran-3-One 256.03
BXGC0014602 Kojic Acid 142.03
BXGC0020680 Mandelic Acid 152.05
BXGC0023330 Methylconiferylaldehyde 192.08
BXGC0025617 Aureusidin 286.05
BXGC0026480 Osajin 404.16
BXGC0033112 Acetylcysteine 163.03
BXGC0034421 n.a 530.14
BXGC0034778 Artemisinin 282.15
BXGC0034783 Doxorubicin 543.17
BXGC0037070 Epicoccolide B 358.07
BXGC0037722 Pomiferin 420.16
BXGC0042127 Oxyquinoline 145.05
BXGC0042231 Pyridine-2,3-Diol 111.03
BXGC0042315 1,4-dioxane 88.05
BXGC0042413 Calcitriol 416.33
BXGC0046518 Chloroquine 319.18
BXGC0047088 Ursolic Acid 456.36
BXGC0047529 2-hydroxybutyric acid 104.05
BXGC0047692 Gefitinib 446.15
BXGC0048689 Sorbic Acid 112.05
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein