Showing entry for 2',4'-Dihydroxychalcone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0039787
Compound Name2',4'-Dihydroxychalcone
Structure
FormulaC15H12O3
InchiKeyJUMSUVHHUVPSOY-RMKNXTFCSA-N
SMILESOc1ccc(c(c1)O)C(=O)/C=C/c1ccccc1
InchiInChI=1S/C15H12O3/c16-12-7-8-13(15(18)10-12)14(17)9-6-11-4-2-1-3-5-11/h1-10,16,18H/b9-6+
IUPAC(E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one
Molecular Weight240.08
Pubchem Id5376979
Chembl IdCHEMBL105310
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50042987
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT004563 Polyphenol oxidase 2 reviewed PPO2 - 110220 - -
reviewed BXGT007824 Arachidonate 5-lipoxygenase reviewed Alox5 - 400000 - -
CHEMBL CHEMBL105310
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 1584 nM
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 11220 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16360 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 44668 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 12589 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 35481 nM
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '<' 20 %
P12527 BXGT007824 Arachidonate 5-lipoxygenase reviewed - Alox5 IC50 '=' 400000 nM
Q63921 BXGT016082 Prostaglandin G/H synthase 1 reviewed - Ptgs1 IC50 '=' 400000 nM
P35355 BXGT009817 Prostaglandin G/H synthase 2 reviewed - Ptgs2 IC50 '=' 400000 nM
P10828 BXGT007624 Thyroid hormone receptor beta reviewed Nuclear receptor THRB Potency '=' 35481 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 56234 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 28183 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 25118 nM
P9WHH3 BXGT012295 Mycothione reductase reviewed - mtr Inhibition - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 39810 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Inhibition - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 31622 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 15848 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 35481 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 35481 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH IC50 - - -
P16050 BXGT008184 Arachidonate 15-lipoxygenase reviewed Enzyme ALOX15 Potency '=' 19952 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 25118 nM
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 '=' 1010 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 2818 nM
P33527 BXGT009728 Multidrug resistance-associated protein 1 reviewed Transporter ABCC1 Inhibition - - -
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH IC50 '=' 107000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00380 White mustard Sinapis alba Herbs and Spices
BXGF00861 Abies pinsapo var. marocana Abies pinsapo var. marocana Others
BXGF01632 Euphrasia genargentea Euphrasia genargentea Others
BXGF01892 Xanthorhiza simplicissima Xanthorhiza simplicissima Medicinal Plant
BXGF03078 Chrysanthemum x morifolium Chrysanthemum x morifolium Medicinal Plant
BXGF03142 Soymida febrifuga Soymida febrifuga Medicinal Plant
BXGF03231 Dactylorhiza viridis Dactylorhiza viridis Others
BXGF03271 Pterolobium hexapetalum Pterolobium hexapetalum Medicinal Plant
BXGF03432 Chrysanthemum indicum Chrysanthemum indicum Medicinal Plant
BXGF03813 Diplopterygium glaucum Diplopterygium glaucum Others
BXGF04057 Abrus pulchellus Abrus pulchellus Medicinal Plant
BXGF04250 Galenia africana Galenia africana Medicinal Plant
BXGF04296 Maytenus chuchuhuasha Maytenus chuchuhuasha Others
BXGF04458 Oxytropis falcata Oxytropis falcata Others
BXGF04842 Angelica acutiloba Angelica acutiloba Medicinal Plant
BXGF05009 Solanum lanceolatum Solanum lanceolatum Medicinal Plant
BXGF05067 Bryonia alba Bryonia alba Medicinal Plant
BXGF05141 Viburnum erubescens Viburnum erubescens Medicinal Plant
BXGF05293 Remirea maritima Remirea maritima Others
BXGF05364 Arnica mollis Arnica mollis Others
BXGF05498 Croton gratissimus Croton gratissimus Medicinal Plant
BXGF05559 Wikstroemia viridiflora Wikstroemia viridiflora Medicinal Plant
BXGF05584 Brassica carinata Brassica carinata Medicinal Plant
BXGF05725 Ranunculus asiaticus Ranunculus asiaticus Others
BXGF05736 Eurycoma harmandiana Eurycoma harmandiana Medicinal Plant
BXGF05840 Eucalyptus resinifera Eucalyptus resinifera Medicinal Plant
BXGF05990 Carpha glomerata Carpha glomerata Others
BXGF06093 Cyanostegia angustifolia Cyanostegia angustifolia Others
BXGF06149 Orthosiphon spicatus Orthosiphon spicatus Medicinal Plant
BXGF06254 Lysimachia fordiana Lysimachia fordiana Others
BXGF06278 Ampelocera edentula Ampelocera edentula Others
BXGF06304 Ixeris debilis Ixeris debilis Others
BXGF06329 Abies excelsa Abies excelsa Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease