Showing entry for 2-Picolinic Acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0040528
Compound Name2-Picolinic Acid
Structure
FormulaC6H5NO2
InchiKeySIOXPEMLGUPBBT-UHFFFAOYSA-N
SMILESOC(=O)c1ccccn1
InchiInChI=1S/C6H5NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H,(H,8,9)
IUPACpyridine-2-carboxylic acid
Molecular Weight123.03
Pubchem Id1018
Chembl IdCHEMBL72628
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB 6PC
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Q9X9P9 BXGT022160 NikD protein unreviewed nikD - - - - -
Q9X9P9 BXGT022160 NikD protein unreviewed nikD - - - 3000000 -
Q1LCS4 BXGT013813 3-hydroxyanthranilate 3,4-dioxygenase reviewed nbaC - - - - -
D5SMY7 BXGT002958 Purine nucleoside phosphorylase unreviewed Plim_2216 - - - - -
A0A0J9X284 BXGT000519 Trap transporter solute binding protein unreviewed - - - - -
A0A0H3LP08 BXGT000465 Putative exported protein unreviewed BB0280 - - - - -
Q41931 BXGT014575 1-aminocyclopropane-1-carboxylate oxidase 2 reviewed ACO2 - - - - -
P24703 BXGT008988 4-hydroxy-tetrahydrodipicolinate reductase reviewed dapB - - - - -
P49419 BXGT010705 Alpha-aminoadipic semialdehyde dehydrogenase reviewed ALDH7A1 Enzyme - - - -
O85725 BXGT025482 Semialdehyde dehydrogenase Pcd unreviewed pcd - - - - -
Binding DB 50000407
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT021246 Transmembrane prolyl 4-hydroxylase reviewed P4HTM - 111500 - -
reviewed BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 18000000 - - -
reviewed BXGT021246 Transmembrane prolyl 4-hydroxylase reviewed P4HTM - 100000 - -
CHEMBL CHEMBL72628
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q6XEC0 BXGT016605 Beta-lactamase unreviewed - bla Kd '>' 1000000 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 35481 nM
Q6TUJ4 BXGT016553 Metallo beta-lactamase unreviewed - blaIMP-1 Activity '=' 54 %
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 2818 nM
Q7Z2H8 BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 Ki '=' 18000000 nM
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Inhibition '=' 6 %
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Inhibition '=' 0 %
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Inhibition '=' 3 %
Q7Z2H8 BXGT017247 Proton-coupled amino acid transporter 1 reviewed Transporter SLC36A1 pKi '=' -1 mM
Q6TUJ4 BXGT016553 Metallo beta-lactamase unreviewed - blaIMP-1 Activity '=' 31 %
Q44079 BXGT014602 Beta-lactamase unreviewed - cphA2 Ki '=' 46000 nM
Q93RY0 BXGT019524 Putative dihydropicolinate synthase unreviewed - SCO6292 IC50 '=' 1000000 nM
P15917 BXGT008169 Lethal factor reviewed - lef Inhibition '=' 49 %
Q9NXG6 BXGT021246 Transmembrane prolyl 4-hydroxylase reviewed - P4HTM IC50 '=' 111500 nM
P0AE18 BXGT007298 Methionine aminopeptidase reviewed - map Inhibition - - -
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 Inhibition '=' 16 %
Q44079 BXGT014602 Beta-lactamase unreviewed - cphA2 Ki '=' 76000 nM
Q44079 BXGT014602 Beta-lactamase unreviewed - cphA2 Ki '=' 440000 nM
P08254 BXGT006758 Stromelysin-1 reviewed Enzyme MMP3 Inhibition '=' 99 %
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 79432 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC Potency '=' 50118 nM
Q9NXG6 BXGT021246 Transmembrane prolyl 4-hydroxylase reviewed - P4HTM IC50 '=' 100000 nM
P9WNS1 BXGT012420 1-deoxy-D-xylulose 5-phosphate reductoisomerase reviewed - dxr Inhibition - - -
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 25929 nM
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 reviewed Epigenetic regulator L3MBTL1 Potency '=' 14125 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 25118 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 14125 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 2059 nM
P08253 BXGT006757 72 kDa type IV collagenase reviewed Enzyme MMP2 Inhibition '=' 25 %
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 3981 nM
Q44079 BXGT014602 Beta-lactamase unreviewed - cphA2 Ki '=' 5700 nM
P52700 BXGT010942 Metallo-beta-lactamase L1 type 3 reviewed - Activity '=' 29 %
Q44079 BXGT014602 Beta-lactamase unreviewed - cphA2 Activity '=' 8 %
O42713 BXGT004563 Polyphenol oxidase 2 reviewed - PPO2 Inhibition '=' 74 %
P22894 BXGT008815 Neutrophil collagenase reviewed Enzyme MMP8 Inhibition '=' 30 %
Q6XEC0 BXGT016605 Beta-lactamase unreviewed - bla IC50 '>' 2000000 nM
Q44079 BXGT014602 Beta-lactamase unreviewed - cphA2 Ki '=' 1100000 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 562 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF01185 Aloe vera Aloe vera Medicinal Plant
BXGF01900 Aloe ferox Aloe ferox Medicinal Plant
BXGF04631 Aloe spicata Aloe spicata Medicinal Plant
BXGF04926 Aloe africana Aloe africana Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease