Showing entry for Transmembrane prolyl 4-hydroxylase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021246
Protein NameTransmembrane prolyl 4-hydroxylase
Uniport IdQ9NXG6
GeneP4HTM
Gene Id54681
Domain2OG-FeII_Oxy_3; EF-hand_7
Pfam PF13640   PF13499  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
Biological Process GO:0045646 regulation of erythrocyte differentiation
molecular function GO:0016706 2-oxoglutarate-dependent dioxygenase activity
molecular function GO:0005509 calcium ion binding
molecular function GO:0005506 iron ion binding
molecular function GO:0031418 L-ascorbic acid binding
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002418 BXGD000112 Amblyopia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004106 BXGD000254 Astigmatism Eye Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0015310 BXGD000976 Exotropia Eye Diseases; Nervous System Diseases
C0015393 BXGD000981 Eye Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0015696 BXGD001014 Fatty Liver, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0020490 BXGD001403 Hyperopia Eye Diseases
C0020672 BXGD001461 Hypothermia, natural Pathological Conditions, Signs and Symptoms
C0022821 BXGD001590 Kyphosis deformity of spine Musculoskeletal Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037315 BXGD002687 Sleep Apnea Syndromes Respiratory Tract Diseases; Nervous System Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0205682 BXGD004105 Waist-Hip Ratio
C0220611 BXGD004295 Childhood Rhabdomyosarcoma Neoplasms
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0241726 BXGD005110 Delayed ability to walk
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0271388 BXGD006196 Pendular Nystagmus Eye Diseases; Nervous System Diseases
C0279550 BXGD006635 Adult Rhabdomyosarcoma Neoplasms
C0340952 BXGD007375 Secondary anemia NOS Hemic and Lymphatic Diseases
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0409338 BXGD008381 Flexion contracture - elbow
C0424139 BXGD008520 Anxiety and fear
C0557874 BXGD009444 Global developmental delay
C0574974 BXGD009508 Finger joint hypermobility
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0694550 BXGD009852 Recurrent pneumonia Infections; Respiratory Tract Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1519670 BXGD013241 Tumor Angiogenesis Pathological Conditions, Signs and Symptoms
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1836543 BXGD014130 Thick vermilion border
C1837260 BXGD014214 Prominent forehead
C1842364 BXGD014511 Central hypotonia
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3203358 BXGD018558 Hypoventilation Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3810365 BXGD019652 Central visual impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3888194 BXGD019955 MIXED LINEAGE LEUKEMIA
C4048268 BXGD021896 Cortical visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4316870 BXGD022707 Abnormality of the eye
C4722524 BXGD023807 Blood Vessel Tumors Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000764 L-Ascorbic acid 176.12
BXGC0040528 2-Picolinic Acid 123.03
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein