acompound

Showing entry for 8-Prenylnaringenin

General Compound Information
BXGC Id	BXGC0042479
Compound Name	8-Prenylnaringenin
Structure
Formula	C20H20O5
InchiKey	LPEPZZAVFJPLNZ-SFHVURJKSA-N
SMILES	CC(=CCc1c(O)cc(c2c1O[C@@H](CC2=O)c1ccc(cc1)O)O)C
Inchi	InChI=1S/C20H20O5/c1-11(2)3-8-14-15(22)9-16(23)19-17(24)10-18(25-20(14)19)12-4-6-13(21)7-5-12/h3-7,9,18,21-23H,8,10H2,1-2H3/t18-/m0/s1
IUPAC	(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
Molecular Weight	340.13
Pubchem Id	480764
Chembl Id	CHEMBL376915

Targets of Information Source

DrugBank

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

19460

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT006059	Estrogen receptor	reviewed	Nuclear receptor	ESR1	-	57	-	-
reviewed	BXGT019366	Estrogen receptor beta	reviewed	Nuclear receptor	ESR2	-	68	-	-
reviewed	BXGT010750	Glycogen synthase kinase-3 beta	reviewed	Kinase	GSK3B	-	-	-	>300000
reviewed	BXGT005174	cGMP-specific 3',5'-cyclic phosphodiesterase	reviewed		PDE5A	-	16230	-	-
reviewed	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	-	>10000	-	-
reviewed	BXGT021792	ATP-binding cassette sub-family G member 2	reviewed	Transporter	ABCG2	-	3100	-	-

CHEMBL

CHEMBL376915

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	reviewed	Transporter	ABCG2	IC50	'='	3100	nM
Q92731	BXGT019366	Estrogen receptor beta	reviewed	Nuclear receptor	ESR2	EC50	'='	5	nM
P09917	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	IC50	'>'	10000	nM
P09917	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	Activity	'='	87	%
P03372	BXGT006059	Estrogen receptor	reviewed	Nuclear receptor	ESR1	Emax	'='	97	%
O14684	BXGT004082	Prostaglandin E synthase	reviewed	-	PTGES	Activity	'='	56	%
P09917	BXGT006941	Arachidonate 5-lipoxygenase	reviewed	Enzyme	ALOX5	Activity	'='	66	%
Q64669	BXGT016128	NAD(P)H dehydrogenase [quinone] 1	reviewed	-	Nqo1	CD	'>'	30	uM
O43497	BXGT004596	Voltage-dependent T-type calcium channel subunit alpha-1G	reviewed	Ion channel	CACNA1G	IC50	'='	1000	nM
Q92731	BXGT019366	Estrogen receptor beta	reviewed	Nuclear receptor	ESR2	Emax	'='	87	%
P03372	BXGT006059	Estrogen receptor	reviewed	Nuclear receptor	ESR1	EC50	'='	7	nM
P03372	BXGT006059	Estrogen receptor	reviewed	Nuclear receptor	ESR1	EC50	'='	5	nM
P03372	BXGT006059	Estrogen receptor	reviewed	Nuclear receptor	ESR1	Emax	'='	108	%
O95180	BXGT005358	Voltage-dependent T-type calcium channel subunit alpha-1H	reviewed	Ion channel	CACNA1H	IC50	'='	1000	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00303	Chia	Salvia hispanica	Herbs and Spices
BXGF00857	Mitracarpus scaber	Mitracarpus scaber	Others
BXGF00998	Syncarpia hillii	Syncarpia hillii	Others
BXGF01168	Erysimum leptophyllum	Erysimum leptophyllum	Others
BXGF01255	Lemaireocereus griseus	Lemaireocereus griseus	Human Edible Plant
BXGF01295	Chondrodendron tomentosum	Chondrodendron tomentosum	Medicinal Plant
BXGF01354	Haplophyllum obtusifolium	Haplophyllum obtusifolium	Others
BXGF01455	Diospyros eriantha	Diospyros eriantha	Others
BXGF01491	Alkanna cappadocica	Alkanna cappadocica	Medicinal Plant
BXGF01524	Artemisia dentata	Artemisia dentata	Others
BXGF01621	Syzygium polycephaloides	Syzygium polycephaloides	Human Edible Plant
BXGF01633	Scorzonera pseudodivaricata	Scorzonera pseudodivaricata	Others
BXGF01649	Rapanea lancifolia	Rapanea lancifolia	Others
BXGF01670	Ononis vaginalis	Ononis vaginalis	Others
BXGF01721	Humulus lupulus	Humulus lupulus	Medicinal Plant
BXGF02202	Piper regnellii	Piper regnellii	Medicinal Plant
BXGF02287	Gymnocalycium schickendantzii	Gymnocalycium schickendantzii	Others
BXGF02306	Plumbago indica	Plumbago indica	Medicinal Plant
BXGF02381	Glycyrrhiza inflata	Glycyrrhiza inflata	Medicinal Plant
BXGF02445	Onopordum acanthium	Onopordum acanthium	Medicinal Plant
BXGF02500	Pancratium sickenbergeri	Pancratium sickenbergeri	Others
BXGF02573	Centaurea maculosa	Centaurea maculosa	Others
BXGF02635	Ephedra sinica	Ephedra sinica	Medicinal Plant
BXGF02653	Macaranga bicolor	Macaranga bicolor	Others
BXGF02663	Atalantia racemosa	Atalantia racemosa	Medicinal Plant
BXGF02695	Plathymenia reticulata	Plathymenia reticulata	Others
BXGF02721	Neurolaena lobata	Neurolaena lobata	Medicinal Plant
BXGF02729	Asimina parviflora	Asimina parviflora	Medicinal Plant
BXGF02774	Pteridium esculentum	Pteridium esculentum	Medicinal Plant
BXGF02813	Esenbeckia leiocarpa	Esenbeckia leiocarpa	Others
BXGF02852	Sophora flavescens	Sophora flavescens	Medicinal Plant
BXGF02929	Hypericum styphelioides	Hypericum styphelioides	Others
BXGF02973	Vellozia nanuzae	Vellozia nanuzae	Others
BXGF02992	Baccharis neglecta	Baccharis neglecta	Others
BXGF03012	Atraphaxis spinosa	Atraphaxis spinosa	Medicinal Plant
BXGF03027	Embelia schimperi	Embelia schimperi	Medicinal Plant
BXGF03087	Epilobium hirsutum	Epilobium hirsutum	Medicinal Plant
BXGF03106	Lythrum salicaria	Lythrum salicaria	Medicinal Plant
BXGF03113	Simarouba glauca	Simarouba glauca	Medicinal Plant
BXGF03126	Erythrina melanacantha	Erythrina melanacantha	Medicinal Plant
BXGF03151	Monsonia senegalensis	Monsonia senegalensis	Human Edible Plant
BXGF03157	Clerodendrum bungei	Clerodendrum bungei	Medicinal Plant
BXGF03186	Lemaireocereus longispinus	Lemaireocereus longispinus	Others
BXGF03197	Eria anomala	Eria anomala	Others
BXGF03208	Embelia parviflora	Embelia parviflora	Medicinal Plant
BXGF03250	Euphorbia nematocypha	Euphorbia nematocypha	Medicinal Plant
BXGF03279	Abelia chinensis	Abelia chinensis	Unclassified
BXGF03297	Diospyros assimilis	Diospyros assimilis	Medicinal Plant
BXGF03310	Faramea salicifolia	Faramea salicifolia	Others
BXGF03342	Buddleja cordata	Buddleja cordata	Others
BXGF03564	Vernonia fagifolia	Vernonia fagifolia	Others
BXGF03570	Cordia leucocephala	Cordia leucocephala	Others
BXGF03747	Millettia erythrocalyx	Millettia erythrocalyx	Medicinal Plant
BXGF03814	Juniperus rigida var. conferta	Juniperus rigida var. conferta	Medicinal Plant
BXGF03978	Hoffmannia strigillosa	Hoffmannia strigillosa	Others
BXGF04584	Helichrysum tenuifolium	Helichrysum tenuifolium	Others
BXGF04872	Glycyrrhiza glabra	Glycyrrhiza glabra	Medicinal Plant
BXGF05010	Morella rubra	Morella rubra	0
BXGF05560	Crambe tatarica	Crambe tatarica	Medicinal Plant
BXGF05752	Astilbe chinensis	Astilbe chinensis	Medicinal Plant
BXGF05790	Glycyrrhiza uralensis	Glycyrrhiza uralensis	Medicinal Plant
BXGF06116	Pteris semipinnata	Pteris semipinnata	Others
BXGF06193	Fritillaria ningguoensis	Fritillaria ningguoensis	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}