Showing entry for Prostaglandin E synthase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004082
Protein NameProstaglandin E synthase
Uniport IdO14684
GenePTGES
Gene Id9536
DomainMAPEG
Pfam PF01124  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00590 Arachidonic acid metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002526 acute inflammatory response
Biological Process GO:0002544 chronic inflammatory response
Biological Process GO:0019371 cyclooxygenase pathway
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0032308 positive regulation of prostaglandin secretion
Biological Process GO:0001516 prostaglandin biosynthetic process
Biological Process GO:0006693 prostaglandin metabolic process
Biological Process GO:0031620 regulation of fever generation
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0034097 response to cytokine
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0014070 response to organic cyclic compound
Biological Process GO:0032526 response to retinoic acid
Biological Process GO:0019233 sensory perception of pain
Biological Process GO:0007165 signal transduction
molecular function GO:0043295 glutathione binding
molecular function GO:0004602 glutathione peroxidase activity
molecular function GO:0004364 glutathione transferase activity
molecular function GO:0004667 prostaglandin-D synthase activity
molecular function GO:0050220 prostaglandin-E synthase activity
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0005641 nuclear envelope lumen
cellular component GO:0048471 perinuclear region of cytoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-2142753 Arachidonic acid metabolism
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-556833 Metabolism of lipids
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006145 BXGD000376 Breast Diseases Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007138 BXGD000446 Carcinoma, Transitional Cell Neoplasms
C0007273 BXGD000455 Carotid Artery Diseases Nervous System Diseases; Cardiovascular Diseases
C0009241 BXGD000595 Cognition Disorders Mental Disorders
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0013274 BXGD000809 Patent ductus arteriosus Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0014070 BXGD000887 Encephalomyelitis Infections; Nervous System Diseases
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0014869 BXGD000966 Peptic Esophagitis Digestive System Diseases
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0016382 BXGD001054 Flushing Pathological Conditions, Signs and Symptoms
C0017638 BXGD001132 Glioma Neoplasms
C0018133 BXGD001176 Graft-vs-Host Disease Immune System Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0019569 BXGD001337 Hirschsprung Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021843 BXGD001520 Intestinal Obstruction Digestive System Diseases
C0022116 BXGD001531 Ischemia Pathological Conditions, Signs and Symptoms
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022876 BXGD001591 Premature Obstetric Labor Female Urogenital Diseases and Pregnancy Complications
C0023601 BXGD001687 Leydig Cell Tumor Neoplasms; Male Urogenital Diseases; Endocrine System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024814 BXGD001809 Marinesco-Sjogren syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0029453 BXGD002154 Osteopenia Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0030354 BXGD002214 Papilloma Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032580 BXGD002362 Adenomatous Polyposis Coli Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Neoplasms
C0032617 BXGD002367 Polyuria Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037286 BXGD002681 Skin Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0041956 BXGD002942 Ureteral obstruction Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085215 BXGD003141 Ovarian Failure, Premature Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0151650 BXGD003454 Renal fibrosis Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0184567 BXGD004039 Acute onset pain Pathological Conditions, Signs and Symptoms
C0205875 BXGD004137 Papillomatosis Neoplasms
C0205969 BXGD004143 Thymic Carcinoma Neoplasms; Hemic and Lymphatic Diseases
C0206698 BXGD004248 Cholangiocarcinoma Neoplasms
C0220668 BXGD004317 Congenital contractural arachnodactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0234985 BXGD004708 Mental deterioration Mental Disorders
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0268575 BXGD005993 Isovaleryl-CoA dehydrogenase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270500 BXGD006077 Coprophilia (disorder) Mental Disorders
C0278882 BXGD006613 Stage III Cutaneous Melanoma AJCC v6
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0334265 BXGD007012 Transitional Cell Neoplasm Neoplasms
C0334294 BXGD007025 Multiple adenomatous polyps Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376618 BXGD008003 Endotoxemia Pathological Conditions, Signs and Symptoms; Infections
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0425449 BXGD008546 Gasping for breath Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677898 BXGD009735 invasive cancer Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0679427 BXGD009777 myeloblastosis Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0856742 BXGD011111 Post MI Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0917996 BXGD011425 Cerebral Aneurysm Nervous System Diseases; Cardiovascular Diseases
C0948008 BXGD011499 Ischemic stroke Nervous System Diseases; Cardiovascular Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1290884 BXGD012198 Inflammatory disorder Pathological Conditions, Signs and Symptoms
C1301034 BXGD012282 Pancreatic intraepithelial neoplasia Neoplasms
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1512981 BXGD013196 Mammary Tumorigenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1536075 BXGD013333 Sudden unexplained death in epilepsy
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1739135 BXGD013733 Progression of prostate cancer
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3853540 BXGD019820 Aspirin exacerbated respiratory disease Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases; Immune System Diseases; Chemically-Induced Disorders; Otorhinolaryngologic Diseases
C3854420 BXGD019832 Autoresuscitation
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C4048329 BXGD021904 Immunosuppression
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4529962 BXGD023178 Fatty Liver Disease
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000537 Acetylsalicylic acid 180.16
BXGC0000663 Papain 206.28
BXGC0000764 L-Ascorbic acid 176.12
BXGC0000894 2-Methylthioribosyl-trans-zeatin 323.8
BXGC0000989 Glutathione 307.32
BXGC0001469 Xanthohumol C 352.38
BXGC0003328 Tetrahydrocurcumin 372.41
BXGC0005513 Hexadecanoic acid 256.42
BXGC0005982 Curcumin 368.38
BXGC0006790 alpha-Elemolic acid 456.7
BXGC0008219 11-Keto-beta-boswellic acid 470.68
BXGC0008873 Xanthohumol 354.4
BXGC0013292 Roburic acid 440.37
BXGC0013582 Curcumin 368.13
BXGC0015579 3,3'-didemethoxynectandrin B 284.14
BXGC0017158 thunberginol A 270.05
BXGC0018153 3-Alpha-Hydroxy-7,24-Diene-Tirucallic Acid 456.36
BXGC0018252 Embelin 294.18
BXGC0018992 3-Alpha-Acetoxy-8,24-Diene-Tirucallic Acid 498.37
BXGC0019171 Atranorin 374.1
BXGC0019226 (+)-Conocarpan 266.13
BXGC0020471 3-Beta-Hydroxy-8,24-Diene-Tirucallic Acid 456.36
BXGC0021006 2-(4-Hydroxyphenyl)-5-(E)-Propenylbenzofuran 250.1
BXGC0021270 Myrtucommulone H 710.4
BXGC0022964 (-)-Larreatricin 284.14
BXGC0023975 Acetyl-Beta-Boswellic Acid 498.37
BXGC0024810 curcumin 368.13
BXGC0028439 2,4,6-Trihydroxy-3-(3,3-Dimethylallyl)Acetophenone 236.1
BXGC0029810 1,5-Bis(4-Hydroxy-3-Methoxyphenyl)-1,4-Pentadien-3-One 326.12
BXGC0029976 2-(2,4-Dihydroxyphenyl)-5-(E)-Propenylbenzofuran 266.09
BXGC0030612 tetraethylene glycol 194.12
BXGC0031521 perlatolinic acid 444.21
BXGC0032830 n-hexyl beta-D-glucopyranoside 264.16
BXGC0033310 Epigalocatechin Gallate 458.08
BXGC0035197 Acetyl-11-Keto-Beta-Boswellic Acid 512.35
BXGC0036831 Humulone 362.21
BXGC0039306 Carnosic Acid 332.2
BXGC0039634 4-[5-(3-Hydroxypropyl)-1-Benzofuran-2-Yl]-3-Methoxyphenol 298.12
BXGC0040254 Rataniaphenol I 280.11
BXGC0042479 8-Prenylnaringenin 340.13
BXGC0043361 Beta-Elemonic Acid 454.34
BXGC0043599 2-[5-(3-Hydroxypropyl)-1-Benzofuran-2-Yl]-5-Methoxyphenol 298.12
BXGC0045323 3-Alpha-Acetoxy-7,24-Diene-Tirucallic Acid 498.37
BXGC0045324 4,(23)-Dihydroroburic acid 442.38
BXGC0045325 4,(23)-Dihydro-11-Keto-Roburic Acid 456.36
BXGC0045326 4,(23)-Dihydroronyctanthic acid 442.38
BXGC0045328 Lupeolic Acid 456.36
BXGC0045329 3-O-Acetyl-Lupeolic Acid 498.37
BXGC0045330 3-O-Acetyl-28-Hydroxy-Lupeolic Acid 514.37
BXGC0046290 Myrtucommulone F 696.39
BXGC0047082 Rataniaphenol Iii 280.11
BXGC0047281 Berberine 336.12
BXGC0048569 Rataniaphenol Ii 264.12
BXGC0050065 Myrtucommulone A 668.36
BXGC0051306 4-((2S,3R)-3-(Hydroxymethyl)-5-((E)-Prop-1-Enyl)-2,3-Dihydrobenzofuran-2-Yl)Phenol 282.13
BXGC0051734 Carnosol 330.18
BXGC0051978 Boswellic Acid 456.36
BXGC0052996 n.a 602.36
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein