Showing entry for Voltage-dependent T-type calcium channel subunit alpha-1H


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005358
Protein NameVoltage-dependent T-type calcium channel subunit alpha-1H
Uniport IdO95180
GeneCACNA1H
Gene Id8912
DomainIon_trans
Pfam PF00520  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
3. Environmental Information Processing 3.2 Signal transduction hsa04020 Calcium signaling pathway
5. Organismal Systems 5.10 Environmental adaptation hsa04713 Circadian entrainment
5. Organismal Systems 5.2 Endocrine system hsa04925 Aldosterone synthesis and secretion
5. Organismal Systems 5.2 Endocrine system hsa04927 Cortisol synthesis and secretion
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04934 Cushing syndrome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032342 aldosterone biosynthetic process
Biological Process GO:0070509 calcium ion import
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0035865 cellular response to potassium ion
Biological Process GO:0034651 cortisol biosynthetic process
Biological Process GO:0098662 inorganic cation transmembrane transport
Biological Process GO:0086010 membrane depolarization during action potential
Biological Process GO:0006936 muscle contraction
Biological Process GO:0007517 muscle organ development
Biological Process GO:0007520 myoblast fusion
Biological Process GO:0019228 neuronal action potential
Biological Process GO:2000344 positive regulation of acrosome reaction
Biological Process GO:0045956 positive regulation of calcium ion-dependent exocytosis
Biological Process GO:0008016 regulation of heart contraction
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0042391 regulation of membrane potential
molecular function GO:0005261 cation channel activity
molecular function GO:0008332 low voltage-gated calcium channel activity
molecular function GO:0046872 metal ion binding
molecular function GO:0097110 scaffold protein binding
molecular function GO:0005244 voltage-gated ion channel activity
molecular function GO:0005248 voltage-gated sodium channel activity
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043005 neuron projection
cellular component GO:0005886 plasma membrane
cellular component GO:0005891 voltage-gated calcium channel complex
cellular component GO:0001518 voltage-gated sodium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-419037 NCAM1 interactions
R-HSA-422475 Axon guidance
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0001890 BXGD000088 Akinetic Petit Mal Nervous System Diseases
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0002875 BXGD000135 Cooley's anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005283 BXGD000308 beta Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0005823 BXGD000339 Blood Pressure
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009777 BXGD000630 Conn Adenoma Neoplasms; Endocrine System Diseases
C0009952 BXGD000639 Febrile Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0013221 BXGD000804 Drug toxicity Chemically-Induced Disorders
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0019025 BXGD001267 Hemoglobin F Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020578 BXGD001434 Hyperventilation Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0030232 BXGD002197 Pallor Pathological Conditions, Signs and Symptoms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041755 BXGD002933 Adverse reaction to drug Chemically-Induced Disorders
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0085578 BXGD003190 Thalassemia Minor Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0149940 BXGD003391 Sciatic Neuropathy Nervous System Diseases
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0200638 BXGD004043 Eosinophil count procedure
C0206686 BXGD004241 Adrenocortical carcinoma Neoplasms; Endocrine System Diseases
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0270850 BXGD006117 Idiopathic generalized epilepsy Nervous System Diseases
C0271979 BXGD006283 Thalassemia Intermedia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0346402 BXGD007823 Malignant neoplasm of adrenal cortex Neoplasms; Endocrine System Diseases
C0432185 BXGD008730 Aplasia of muscle Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0458247 BXGD008904 Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0476254 BXGD008984 Dyslexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596887 BXGD009648 mathematical ability
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0679136 BXGD009759 Low self-esteem Behavior and Behavior Mechanisms
C0751124 BXGD010327 Epilepsy, Absence, Atypical Nervous System Diseases
C0751211 BXGD010350 Hyperalgesia, Primary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751212 BXGD010351 Hyperalgesia, Secondary Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751213 BXGD010352 Tactile Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0855389 BXGD011085 Renin decreased
C1096063 BXGD011600 Drug Resistant Epilepsy Nervous System Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384514 BXGD012940 Conn Syndrome Endocrine System Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1838604 BXGD014325 EPILEPSY, CHILDHOOD ABSENCE, 1
C1854686 BXGD015423 Uncontrolled eye movements
C1855568 BXGD015511 Jerky head movements
C1963933 BXGD016705 Punding Mental Disorders
C2677793 BXGD017387 EPILEPSY, IDIOPATHIC GENERALIZED, SUSCEPTIBILITY TO, 6
C2749872 BXGD017637 EPILEPSY, CHILDHOOD ABSENCE, SUSCEPTIBILITY TO, 6
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3539781 BXGD019086 Progressive cGVHD
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021085 BXGD020544 Abnormality of brain morphology
C4021087 BXGD020546 Abnormal social behavior Behavior and Behavior Mechanisms
C4023685 BXGD021242 EEG with spike-wave complexes (2.5-3.5 Hz)
C4023701 BXGD021248 Impaired visuospatial constructive cognition
C4281785 BXGD022415 Childhood Absence Epilepsy Nervous System Diseases
C4310756 BXGD022653 HYPERALDOSTERONISM, FAMILIAL, TYPE IV
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317339 BXGD022739 Juvenile Absence Epilepsy Nervous System Diseases
C4477055 BXGD022912 Limb myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505072 BXGD022953 Epileptic Syndromes Nervous System Diseases
C4552765 BXGD023522 Epilepsy, Minor Nervous System Diseases
C4553705 BXGD023547 Absence Seizure Disorder Nervous System Diseases
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003611 Latex 416.57
BXGC0006372 Ergocalciferol 396.65
BXGC0008667 6-Prenylnaringenin 340.38
BXGC0008842 (S)-5,7-Dihydroxy-6-prenylflavanone 324.37
BXGC0024428 3-(1H-Benzimidazol-2-Yl)-7-(Diethylamino)Chromen-2-One 333.15
BXGC0024988 Nifedipine 346.12
BXGC0029662 Sophoraflavanone G 424.19
BXGC0040150 Cannabidiol 314.22
BXGC0042479 8-Prenylnaringenin 340.13
BXGC0044017 Verapamil 454.28
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein