acompound

Showing entry for Guanosine

General Compound Information
BXGC Id	BXGC0048348
Compound Name	Guanosine
Structure
Formula	C10H13N5O5
InchiKey	NYHBQMYGNKIUIF-UUOKFMHZSA-N
SMILES	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1[nH]c(=N)nc2O
Inchi	InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
IUPAC	2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Molecular Weight	283.09
Pubchem Id	135398635
Chembl Id	CHEMBL375655

Targets of Information Source

DrugBank

DB02857

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Q38087	BXGT014334	DNA-directed DNA polymerase	reviewed	-	43	experimental; investigational	-
P00491	BXGT005555	Purine nucleoside phosphorylase	reviewed	Enzyme	PNP	experimental; investigational	-
Q5SID9	BXGT015713	Purine nucleoside phosphorylase	unreviewed	-	TTHA1435	experimental; investigational	-

PDB

GMP

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Q38087	BXGT014334	DNA-directed DNA polymerase	reviewed	43	-	-	-	-	-
P50389	BXGT010795	Purine nucleoside phosphorylase	reviewed	SSO2706	-	-	-	-	-
Q5SID9	BXGT015713	Purine nucleoside phosphorylase	unreviewed	TTHA1435	-	-	-	80000	-
P00491	BXGT005555	Purine nucleoside phosphorylase	reviewed	PNP	Enzyme	-	-	-	-
P60546	BXGT011314	Guanylate kinase	reviewed	gmk	-	-	-	-	-
P29724	BXGT009376	Membrane lipoprotein TmpC	reviewed	tmpC	-	-	-	71	-
A5KE01	BXGT001346	Adenosine deaminase, putative	unreviewed	PVX_111245	-	-	-	-	-
Q5SKW0	BXGT015782	Probable ribosomal RNA small subunit methyltransferase	unreviewed	TTHA0533	-	-	-	-	-
Q9BMI9	BXGT020101	Purine nucleoside phosphorylase	unreviewed		-	-	-	-	-
O68183	BXGT005025	APH(2'')-Id	unreviewed	aph(2'')-Id	-	-	-	-	-
Q2KDX6	BXGT014114	Probable sugar kinase protein	unreviewed	RHE_CH00135	-	-	-	-	-
P40997	BXGT010215	mRNA-capping enzyme subunit alpha	reviewed	ceg1	-	-	-	-	-
Q91L20	BXGT019295	Large structural protein	unreviewed	L	-	-	-	-	-
O74859	BXGT005090	Aprataxin-like protein	reviewed	hnt3	-	-	-	-	-
B3Y653	BXGT002084	Toll-like receptor 7	unreviewed	TLR7	-	-	-	1000	-
Q47396	BXGT014706	Macrolide 2'-phosphotransferase	unreviewed	mphA	-	-	-	-	-
F8WJP6	BXGT003332	Gdp-mannose 4,6-dehydratase / gdp-4-amino-4,6-dideoxy-d-mannose formyltransferase	unreviewed	BMEI1418	-	-	-	-	-
Q86RB0	BXGT024250	Protein kinase A regulatory subunit	unreviewed	PKAR	-	-	-	-	-

Binding DB

50366814

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT008878	Adenosylhomocysteinase	reviewed	Enzyme	AHCY	1472000	-	-	-

CHEMBL

CHEMBL375655

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P23526	BXGT008878	Adenosylhomocysteinase	reviewed	Enzyme	AHCY	Ki	'='	1472000	nM
P46063	BXGT010501	ATP-dependent DNA helicase Q1	reviewed	Enzyme	RECQL	Potency	'='	3981	nM
P23526	BXGT008878	Adenosylhomocysteinase	reviewed	Enzyme	AHCY	k cat	'='	0	M-1
P00492	BXGT005556	Hypoxanthine-guanine phosphoribosyltransferase	reviewed	Enzyme	HPRT1	Activity	-	-	-
P00491	BXGT005555	Purine nucleoside phosphorylase	reviewed	Enzyme	PNP	Km	'='	83000	nM
P23526	BXGT008878	Adenosylhomocysteinase	reviewed	Enzyme	AHCY	Km	'='	844000	nM
P00491	BXGT005555	Purine nucleoside phosphorylase	reviewed	Enzyme	PNP	Activity	'='	100	%

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00042	Safflower	Carthamus tinctorius	Herbs and Spices
BXGF00162	Red raspberry	Rubus idaeus	Fruits
BXGF00522	Narrowleaf cattail	Typha angustifolia	Vegetables
BXGF01056	Geigeria schinzii	Geigeria schinzii	Others
BXGF01093	Fritillaria pallidiflora	Fritillaria pallidiflora	Medicinal Plant
BXGF01267	Dendrobium chrysanthum	Dendrobium chrysanthum	Medicinal Plant
BXGF01287	Papaver radicatum	Papaver radicatum	Others
BXGF01347	Fritillaria delavayi	Fritillaria delavayi	Medicinal Plant
BXGF01413	Fritillaria verticillata	Fritillaria verticillata	Medicinal Plant
BXGF01420	Pinus glauca	Pinus glauca	Others
BXGF01479	Fritillaria cirrhosa	Fritillaria cirrhosa	Medicinal Plant
BXGF01496	Ophryosporus charua	Ophryosporus charua	Others
BXGF01514	Blainvillea latifolia	Blainvillea latifolia	Others
BXGF01636	Prosopis kuntzei	Prosopis kuntzei	Medicinal Plant
BXGF01677	Leontice kiangnanensis	Leontice kiangnanensis	Others
BXGF01705	Cheilanthes marantae	Cheilanthes marantae	Others
BXGF01776	Fritillaria prezewalskii	Fritillaria prezewalskii	Others
BXGF01780	Selaginella tamariscina	Selaginella tamariscina	Medicinal Plant
BXGF01808	Helichrysum angustifolium	Helichrysum angustifolium	Others
BXGF01868	Vitex negundo	Vitex negundo	Medicinal Plant
BXGF01913	Fritillaria unibracteata	Fritillaria unibracteata	Medicinal Plant
BXGF01973	Lonicera japonica	Lonicera japonica	Medicinal Plant
BXGF02049	Angelica sinensis	Angelica sinensis	Medicinal Plant
BXGF02725	Fritillaria walujewii	Fritillaria walujewii	Medicinal Plant
BXGF02815	Pinellia ternata	Pinellia ternata	Medicinal Plant
BXGF02847	Podocarpus elongata	Podocarpus elongata	Others
BXGF03068	Stenocereus thurberi	Stenocereus thurberi	Human Edible Plant
BXGF03161	Dendrobium chrysotoxum	Dendrobium chrysotoxum	Medicinal Plant
BXGF03346	Dendrobium candidum	Dendrobium candidum	Others
BXGF03348	Panax notoginseng	Panax notoginseng	Medicinal Plant
BXGF03439	Fritillaria przewalskii	Fritillaria przewalskii	Medicinal Plant
BXGF03444	Gastrodia elata	Gastrodia elata	Medicinal Plant
BXGF03632	Dendrobium fimbriatum	Dendrobium fimbriatum	Medicinal Plant
BXGF03811	Euryale ferox	Euryale ferox	Medicinal Plant
BXGF03879	Arisaema heterophyllum	Arisaema heterophyllum	Medicinal Plant
BXGF03901	Astragalus membranaceus	Astragalus membranaceus	Medicinal Plant
BXGF03940	Pachycereus pringlei	Pachycereus pringlei	Human Edible Plant
BXGF04103	Fritillaria taipaiensis	Fritillaria taipaiensis	Others
BXGF04585	Arisaema amurense	Arisaema amurense	Medicinal Plant
BXGF04595	Abelmoschus manihot	Abelmoschus manihot	Medicinal Plant
BXGF04600	Typha orientalis	Typha orientalis	Medicinal Plant
BXGF04643	Selaginella pulvinata	Selaginella pulvinata	Medicinal Plant
BXGF04680	Eschweilera coriacea	Eschweilera coriacea	Human Edible Plant
BXGF04698	Isodon rubescens	Isodon rubescens	Others
BXGF04820	Panax ginseng	Panax ginseng	0
BXGF04889	Pogostemon cablin	Pogostemon cablin	Medicinal Plant
BXGF05113	Bersama swinnyi	Bersama swinnyi	Others
BXGF05159	Eucalyptus cladocalyx	Eucalyptus cladocalyx	Medicinal Plant
BXGF05173	Dendrobium nobile	Dendrobium nobile	Medicinal Plant
BXGF05281	Fritillaria thunbergii	Fritillaria thunbergii	Medicinal Plant
BXGF05297	Isatis tinctoria	Isatis tinctoria	Medicinal Plant
BXGF05330	Arum ternatum thunb	Arum ternatum thunb	Others
BXGF05499	Arisaema erubescens	Arisaema erubescens	Medicinal Plant
BXGF05505	Fritillaria ussuriensis	Fritillaria ussuriensis	Medicinal Plant
BXGF05510	Ulva pertusa	Ulva pertusa	Medicinal Plant
BXGF05571	Ziziphus jujuba	Ziziphus jujuba	Medicinal Plant
BXGF05573	Goniothalamus undulatus	Goniothalamus undulatus	Others
BXGF05688	Salvadora persica	Salvadora persica	Medicinal Plant
BXGF05690	Pteris spinulosa	Pteris spinulosa	Others
BXGF05756	Cistanche tubulosa	Cistanche tubulosa	Medicinal Plant
BXGF05915	Fritillaria hupehensis	Fritillaria hupehensis	Medicinal Plant
BXGF05962	Rehmannia glutinosa	Rehmannia glutinosa	Medicinal Plant
BXGF06066	Nemuaron humboldtii	Nemuaron humboldtii	Others
BXGF06069	Dendrobium loddigesii	Dendrobium loddigesii	Medicinal Plant
BXGF06099	Lophocereus marginatus	Lophocereus marginatus	Medicinal Plant
BXGF06117	Helichrysum sutherlandii	Helichrysum sutherlandii	Medicinal Plant
BXGF06134	Aralidium pinnatifidum	Aralidium pinnatifidum	Others
BXGF06143	Persicaria tinctoria	Persicaria tinctoria	Medicinal Plant
BXGF06185	Ophiopogon japonicus	Ophiopogon japonicus	Medicinal Plant
BXGF06265	Euphorbia resinifera	Euphorbia resinifera	Medicinal Plant
BXGF06320	Eurycoma longifolia	Eurycoma longifolia	Medicinal Plant
BXGF06321	Peltodon longipes	Peltodon longipes	Others

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}