Showing entry for Adenosylhomocysteinase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008878
Protein NameAdenosylhomocysteinase
Uniport IdP23526
GeneAHCY
Gene Id191
DomainAdoHcyase; AdoHcyase_NAD
Pfam PF05221   PF00670  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00270 Cysteine and methionine metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0002439 chronic inflammatory response to antigenic stimulus
Biological Process GO:0042745 circadian sleep/wake cycle
Biological Process GO:0032259 methylation
Biological Process GO:0006730 one-carbon metabolic process
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0007584 response to nutrient
Biological Process GO:0019510 S-adenosylhomocysteine catabolic process
Biological Process GO:0033353 S-adenosylmethionine cycle
Biological Process GO:0000096 sulfur amino acid metabolic process
molecular function GO:0004013 adenosylhomocysteinase activity
molecular function GO:0030554 adenyl nucleotide binding
molecular function GO:0042802 identical protein binding
molecular function GO:0051287 NAD binding
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0042470 melanosome
cellular component GO:0043005 neuron projection
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1430728 Metabolism
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-156581 Methylation
R-HSA-1614635 Sulfur amino acid metabolism
R-HSA-1643685 Disease
R-HSA-211859 Biological oxidations
R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se
R-HSA-2408522 Selenoamino acid metabolism
R-HSA-5578997 Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
R-HSA-5579029 Metabolic disorders of biological oxidation enzymes
R-HSA-5668914 Diseases of metabolism
R-HSA-71291 Metabolism of amino acids and derivatives
R-HSA-71291 Metabolism of amino acids and derivatives
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001339 BXGD000041 Acute pancreatitis Digestive System Diseases
C0002514 BXGD000118 Amino Acid Metabolism, Inborn Errors Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0003129 BXGD000182 Anoxemia Pathological Conditions, Signs and Symptoms
C0003130 BXGD000183 Anoxia Pathological Conditions, Signs and Symptoms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0008479 BXGD000544 Chondrosarcoma Neoplasms
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0014877 BXGD000967 Esotropia Eye Diseases; Nervous System Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017658 BXGD001138 Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019202 BXGD001302 Hepatolenticular Degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C0020305 BXGD001374 Hydrops Fetalis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0023290 BXGD001631 Leishmaniasis, Visceral Infections
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0035410 BXGD002546 Rhabdomyolysis Musculoskeletal Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0085605 BXGD003200 Liver Failure Digestive System Diseases
C0151872 BXGD003493 Prothrombin time increased Hemic and Lymphatic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0162871 BXGD003996 Aortic Aneurysm, Abdominal Cardiovascular Diseases
C0239981 BXGD005011 Hypoalbuminemia Hemic and Lymphatic Diseases
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0242184 BXGD005140 Hypoxia Pathological Conditions, Signs and Symptoms
C0262444 BXGD005244 Abnormality of the dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0262630 BXGD005262 Reduced concentration span Behavior and Behavior Mechanisms
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0268621 BXGD006012 Hepatic methionine adenosyltransferase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0272375 BXGD006359 Antithrombin III Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0349653 BXGD007946 Congenital disorder of glycosylation type 1A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0398650 BXGD008212 Immune thrombocytopenic purpura Pathological Conditions, Signs and Symptoms; Immune System Diseases; Hemic and Lymphatic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0456070 BXGD008863 Growth delay
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0553681 BXGD009406 Hypofibrinogenemia
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598608 BXGD009668 Hyperhomocysteinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700292 BXGD009884 Hypoxemia Pathological Conditions, Signs and Symptoms
C0740391 BXGD009987 Middle Cerebral Artery Occlusion Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0750905 BXGD010243 Amino Acid Metabolism, Inherited Disorders Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0751202 BXGD010347 Cystathionine beta-Synthase Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Nervous System Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0919677 BXGD011435 Protein C measurement
C0936215 BXGD011476 Vitamin B 6 Deficiency Nutritional and Metabolic Diseases
C1112256 BXGD011655 Sensorimotor neuropathy
C1145670 BXGD011764 Respiratory Failure Respiratory Tract Diseases
C1168438 BXGD011793 Protein C antigen measurement
C1277241 BXGD012110 Delayed myelination Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1527352 BXGD013278 Hepatic Form of Wilson Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases; Nervous System Diseases
C1531647 BXGD013301 Cerebral ventriculomegaly Nervous System Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836830 BXGD014165 Developmental regression Mental Disorders
C1846151 BXGD014787 Widened subarachnoid space
C1847720 BXGD014883 Hypermethioninemia due to deficiency of glycine N-methyltransferase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C1848529 BXGD014935 Hypoplasia of the pons
C1848701 BXGD014967 Elevated hepatic transaminase
C1849265 BXGD015028 Overgrowth
C1854301 BXGD015391 Motor delay Mental Disorders
C1860834 BXGD016006 Infantile muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2938912 BXGD018165 Hyperintensity of cerebral white matter on MRI Pathological Conditions, Signs and Symptoms
C3151058 BXGD018379 S-adenosylhomocysteine hydrolase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3278923 BXGD018748 Dilated ventricles (finding)
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3806347 BXGD019506 Hyperhomocystinemia
C4021106 BXGD020556 Elevated coagulation factor V activity
C4023722 BXGD021253 Abnormality of hair texture
C4024722 BXGD021385 Reduced factor VII activity
C4025616 BXGD021697 CNS hypomyelination
C4048705 BXGD021907 Hypermethioninemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4316812 BXGD022704 Fibrinogen Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4510276 BXGD022983 Psychomotor retardation due to S-adenosylhomocysteine hydrolase deficiency Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4529962 BXGD023178 Fatty Liver Disease
C4551463 BXGD023300 Colon adenoma Digestive System Diseases; Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002605 Adenosine 267.24
BXGC0002616 Copper 63.55
BXGC0004266 2-Propanol 60.1
BXGC0017352 Methylthioadenosine 297.09
BXGC0047430 Inosine 268.08
BXGC0048348 Guanosine 283.09
BXGC0052972 Aristeromycin 265.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein