Showing entry for Syntenin-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003937
Protein NameSyntenin-1
Uniport IdO00560
GeneSDCBP
Gene Id6386
DomainPDZ; PDZ_6
Pfam PF00595   PF17820  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0002091 negative regulation of receptor internalization
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0010718 positive regulation of epithelial to mesenchymal transition
Biological Process GO:1903543 positive regulation of exosomal secretion
Biological Process GO:1903553 positive regulation of extracellular exosome assembly
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
Biological Process GO:0042327 positive regulation of phosphorylation
Biological Process GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0006612 protein targeting to membrane
Biological Process GO:0007346 regulation of mitotic cell cycle
Biological Process GO:0006930 substrate-dependent cell migration, cell extension
molecular function GO:0008093 cytoskeletal anchor activity
molecular function GO:0005109 frizzled binding
molecular function GO:0042802 identical protein binding
molecular function GO:0005137 interleukin-5 receptor binding
molecular function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
molecular function GO:0046982 protein heterodimerization activity
molecular function GO:0047485 protein N-terminus binding
molecular function GO:0045545 syndecan binding
cellular component GO:0005912 adherens junction
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0072562 blood microparticle
cellular component GO:0005737 cytoplasm
cellular component GO:0005856 cytoskeleton
cellular component GO:0005829 cytosol
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:1903561 extracellular vesicle
cellular component GO:0005925 focal adhesion
cellular component GO:0005895 interleukin-5 receptor complex
cellular component GO:0042470 melanosome
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0031965 nuclear membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0045202 synapse
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-373760 L1CAM interactions
R-HSA-3928664 Ephrin signaling
R-HSA-422475 Axon guidance
R-HSA-447043 Neurofascin interactions
R-HSA-5213460 RIPK1-mediated regulated necrosis
R-HSA-5218859 Regulated Necrosis
R-HSA-5357801 Programmed Cell Death
R-HSA-5675482 Regulation of necroptotic cell death
R-HSA-6798695 Neutrophil degranulation
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153633 BXGD003674 Malignant neoplasm of brain Neoplasms; Nervous System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0153690 BXGD003684 Secondary malignant neoplasm of bone Pathological Conditions, Signs and Symptoms; Neoplasms; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0220633 BXGD004303 Uveal melanoma Neoplasms; Eye Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0276093 BXGD006400 edema disease Infections
C0278488 BXGD006515 Carcinoma breast stage IV
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280216 BXGD006719 stage, neuroblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0343641 BXGD007636 Human papilloma virus infection Infections
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2938924 BXGD018167 Oestrogen receptor positive breast cancer
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2945759 BXGD018189 aggressive cancer
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0004560 Benzoic acid 122.12
BXGC0006697 Water 18.02
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein