Showing entry for Malignant neoplasm of brain


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD003674
Disease NameMalignant neoplasm of brain
Disease CUI IdC0153633
MeSH Codes C04   C10  
Disease Class NameNeoplasms; Nervous System Diseases
Semantic TypeNeoplastic Process
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7   DOID:14566  
Disease Ontology Class Namedisease of anatomical entity; disease of cellular proliferation
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00522 BXGT003935 Krev interaction trapped protein 1 889 reviewed
O00560 BXGT003937 Syntenin-1 6386 reviewed Transporter
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 1111 reviewed Kinase
O14980 BXGT004119 Exportin-1 7514 reviewed Receptor
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 4864 reviewed Transporter
O15269 BXGT004145 Serine palmitoyltransferase 1 10558 reviewed Enzyme
O15350 BXGT004154 Tumor protein p73 7161 reviewed Transcription factor
O15540 BXGT004178 Fatty acid-binding protein, brain 2173 reviewed
O43557 BXGT004600 Tumor necrosis factor ligand superfamily member 14 8740 reviewed Signaling
O60341 BXGT004873 Lysine-specific histone demethylase 1A 23028 reviewed Epigenetic regulator
O60858 BXGT004903 E3 ubiquitin-protein ligase TRIM13 10206 reviewed
O60885 BXGT004906 Bromodomain-containing protein 4 23476 reviewed Epigenetic regulator
O75473 BXGT005129 Leucine-rich repeat-containing G-protein coupled receptor 5 8549 reviewed G-protein coupled receptor
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic 3417 reviewed
O95970 BXGT005409 Leucine-rich glioma-inactivated protein 1 9211 reviewed
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00749 BXGT005641 Urokinase-type plasminogen activator 5328 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01106 BXGT005730 Myc proto-oncogene protein 4609 reviewed Transcription factor
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01732 BXGT005782 T-cell surface glycoprotein CD8 alpha chain 925 reviewed
P02786 BXGT005961 Transferrin receptor protein 1 7037 reviewed Enzyme
P02787 BXGT005962 Serotransferrin 7018 reviewed Enzyme
P03950 BXGT006116 Angiogenin 283 reviewed
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 2064 reviewed Kinase
P04629 BXGT006239 High affinity nerve growth factor receptor 4914 reviewed Kinase
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P04798 BXGT006265 Cytochrome P450 1A1 1543 reviewed Enzyme
P05106 BXGT006315 Integrin beta-3 3690 reviewed Receptor
P05107 BXGT006316 Integrin beta-2 3689 reviewed Receptor
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05181 BXGT006337 Cytochrome P450 2E1 1571 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P06748 BXGT006497 Nucleophosmin 4869 reviewed Chaperone
P07237 BXGT006576 Protein disulfide-isomerase 5034 reviewed
P07288 BXGT006591 Prostate-specific antigen 354 reviewed Enzyme
P07355 BXGT006609 Annexin A2 302 reviewed
P07900 BXGT006696 Heat shock protein HSP 90-alpha 3320 reviewed Chaperone
P07949 BXGT006703 Proto-oncogene tyrosine-protein kinase receptor Ret 5979 reviewed Kinase
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P08670 BXGT006810 Vimentin 7431 reviewed
P08922 BXGT006843 Proto-oncogene tyrosine-protein kinase ROS 6098 reviewed Kinase
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P0DMV8 BXGT007509 Heat shock 70 kDa protein 1A 3304 reviewed
P0DMV9 BXGT007510 Heat shock 70 kDa protein 1B 3304 reviewed
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P10997 BXGT007643 Islet amyloid polypeptide 3375 reviewed Signaling
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P11712 BXGT007738 Cytochrome P450 2C9 1559 reviewed
P11802 BXGT007750 Cyclin-dependent kinase 4 1019 reviewed Kinase
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12268 BXGT007783 Inosine-5'-monophosphate dehydrogenase 2 3615 reviewed Enzyme
P13726 BXGT007950 Tissue factor 2152 reviewed Receptor
P14324 BXGT008005 Farnesyl pyrophosphate synthase 2224 reviewed Enzyme
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 3620 reviewed
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16070 BXGT008186 CD44 antigen 960 reviewed
P16234 BXGT008209 Platelet-derived growth factor receptor alpha 5156 reviewed Kinase
P16455 BXGT008229 Methylated-DNA--protein-cysteine methyltransferase 4255 reviewed
P19367 BXGT008476 Hexokinase-1 3098 reviewed Kinase
P21980 BXGT008715 Protein-glutamine gamma-glutamyltransferase 2 7052 reviewed Enzyme
P22413 BXGT008764 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 5167 reviewed Enzyme
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P29317 BXGT009331 Ephrin type-A receptor 2 1969 reviewed Kinase
P29323 BXGT009334 Ephrin type-B receptor 2 2048 reviewed Kinase
P30086 BXGT009400 Phosphatidylethanolamine-binding protein 1 5037 reviewed Enzyme modulator
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P39060 BXGT010088 Collagen alpha-1(XVIII) chain 80781 reviewed
P40692 BXGT010195 DNA mismatch repair protein Mlh1 4292 reviewed Nucleic acid binding
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41161 BXGT010229 ETS translocation variant 5 2119 reviewed Transcription factor
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46937 BXGT010554 Transcriptional coactivator YAP1 10413 reviewed Enzyme modulator
P46940 BXGT010556 Ras GTPase-activating-like protein IQGAP1 8826 reviewed Enzyme modulator
P47895 BXGT010593 Aldehyde dehydrogenase family 1 member A3 220 reviewed Enzyme
P48060 BXGT010615 Glioma pathogenesis-related protein 1 11010 reviewed Immune response
P48730 BXGT010656 Casein kinase I isoform delta 1453 reviewed Kinase
P48735 BXGT010657 Isocitrate dehydrogenase [NADP], mitochondrial 3418 reviewed
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P52701 BXGT010943 DNA mismatch repair protein Msh6 2956 reviewed Nucleic acid binding
P52789 BXGT010954 Hexokinase-2 3099 reviewed Kinase
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P55087 BXGT011105 Aquaporin-4 361 reviewed Ion channel
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P62805 BXGT011457 Histone H4 8370 reviewed
P62937 BXGT011471 Peptidyl-prolyl cis-trans isomerase A 5478 reviewed
P68363 BXGT011594 Tubulin alpha-1B chain 10376 reviewed Cellular structure
P78310 BXGT011830 Coxsackievirus and adenovirus receptor 1525 reviewed
P78325 BXGT011832 Disintegrin and metalloproteinase domain-containing protein 8 101 reviewed Enzyme
Q00987 BXGT012559 E3 ubiquitin-protein ligase Mdm2 4193 reviewed Nucleic acid binding
Q01094 BXGT012568 Transcription factor E2F1 1869 reviewed Nucleic acid binding
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q07021 BXGT012915 Complement component 1 Q subcomponent-binding protein, mitochondrial 708 reviewed
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 4170 reviewed Signaling
Q08050 BXGT012958 Forkhead box protein M1 2305 reviewed
Q08345 BXGT012982 Epithelial discoidin domain-containing receptor 1 780 reviewed Kinase
Q09028 BXGT013025 Histone-binding protein RBBP4 5928 reviewed
Q10589 BXGT013203 Bone marrow stromal antigen 2 684 reviewed
Q13153 BXGT013319 Serine/threonine-protein kinase PAK 1 5058 reviewed Kinase
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13535 BXGT013370 Serine/threonine-protein kinase ATR 545 reviewed Kinase
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1859 reviewed Kinase
Q14680 BXGT013499 Maternal embryonic leucine zipper kinase 9833 reviewed Kinase
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 9970 reviewed Nuclear receptor
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15465 BXGT013573 Sonic hedgehog protein 6469 reviewed
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16548 BXGT013636 Bcl-2-related protein A1 597 reviewed Signaling
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16790 BXGT013670 Carbonic anhydrase 9 768 reviewed
Q53EL6 BXGT015008 Programmed cell death protein 4 27250 reviewed Nucleic acid binding
Q58F21 BXGT015228 Bromodomain testis-specific protein 676 reviewed Epigenetic regulator
Q92876 BXGT019388 Kallikrein-6 5653 reviewed Enzyme
Q96D42 BXGT019636 Hepatitis A virus cellular receptor 1 26762 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q99574 BXGT019936 Neuroserpin 5274 reviewed Enzyme modulator
Q99835 BXGT019969 Smoothened homolog 6608 reviewed G-protein coupled receptor
Q9BZR6 BXGT020202 Reticulon-4 receptor 65078 reviewed
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9H0P0 BXGT020439 Cytosolic 5'-nucleotidase 3A 51251 reviewed Enzyme
Q9NP58 BXGT021143 ATP-binding cassette sub-family B member 6, mitochondrial 10058 reviewed Transporter
Q9NRG4 BXGT021187 N-lysine methyltransferase SMYD2 56950 reviewed Epigenetic regulator
Q9UBB5 BXGT021649 Methyl-CpG-binding domain protein 2 8932 reviewed Epigenetic regulator
Q9UHX3 BXGT021708 Adhesion G protein-coupled receptor E2 30817 reviewed G-protein coupled receptor
Q9UJU2 BXGT021730 Lymphoid enhancer-binding factor 1 51176 reviewed
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9UQF0 BXGT021812 Syncytin-1 30816 reviewed
Q9Y2Q3 BXGT022242 Glutathione S-transferase kappa 1 373156 reviewed
Q9Y468 BXGT022270 Lethal(3)malignant brain tumor-like protein 1 26013 reviewed Epigenetic regulator
Q9UNS1 BXGT022882 Protein timeless homolog 8914 reviewed
P35240 BXGT022927 Merlin 4771 reviewed
Q01543 BXGT023137 Friend leukemia integration 1 transcription factor 2313 reviewed Transcription factor
A8MW92 BXGT024730 PHD finger protein 20-like protein 1 51105 reviewed
Q13635 BXGT024910 Protein patched homolog 1 5727 reviewed
Q9UGM3 BXGT025543 Deleted in malignant brain tumors 1 protein 1755 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease