Showing entry for Prolyl 4-hydroxylase subunit alpha-2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004172
Protein NameProlyl 4-hydroxylase subunit alpha-2
Uniport IdO15460
GeneP4HA2
Gene Id8974
Domain2OG-FeII_Oxy_3; P4Ha_N
Pfam PF13640   PF08336  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00330 Arginine and proline metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
molecular function GO:0009055 electron transfer activity
molecular function GO:0005506 iron ion binding
molecular function GO:0031418 L-ascorbic acid binding
molecular function GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
molecular function GO:0004656 procollagen-proline 4-dioxygenase activity
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0005654 nucleoplasm
Reactome
Pathway Id Pathway Name
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474290 Collagen formation
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005890 BXGD000345 Body Height
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0007847 BXGD000492 Malignant tumor of cervix Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0027092 BXGD001971 Myopia Eye Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0039483 BXGD002813 Giant Cell Arteritis Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C0040420 BXGD002861 Tonometry
C0042384 BXGD002979 Vasculitis Cardiovascular Diseases
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0079744 BXGD003090 Diffuse Large B-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0200638 BXGD004043 Eosinophil count procedure
C0200641 BXGD004044 Blood basophil count (lab test)
C0206731 BXGD004276 Angiofibroma Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0221228 BXGD004412 Comedone Skin and Connective Tissue Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0271183 BXGD006169 Severe myopia Eye Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0302592 BXGD006851 Cervix carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0427460 BXGD008616 Red cell distribution width determination
C0585362 BXGD009592 Squamous cell carcinoma of mouth Digestive System Diseases; Neoplasms; Stomatognathic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1956391 BXGD016630 Temporal Arteritis Skin and Connective Tissue Diseases; Immune System Diseases; Nervous System Diseases; Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2985280 BXGD018223 Blood Protein Measurement
C4048328 BXGD021903 cervical cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C4310655 BXGD022615 MYOPIA 25, AUTOSOMAL DOMINANT
C4721413 BXGD023737 Juvenile angiofibroma Neoplasms; Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000226 Glycine 75.07
BXGC0000288 L-Proline 115.13
BXGC0000441 Dimethyl sulfoxide 78.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein