adisease

Showing entry for Myopia

General Disease Information
BXGD Id	BXGD001971
Disease Name	Myopia
Disease CUI Id	C0027092
MeSH Codes	C11
Disease Class Name	Eye Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000478
Human Phenotype Ontology Term	Abnormality of the eye
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O14936	BXGT004114	Peripheral plasma membrane protein CASK	8573	reviewed	Kinase
O15230	BXGT004138	Laminin subunit alpha-5	3911	reviewed	Enzyme modulator
O15303	BXGT004150	Metabotropic glutamate receptor 6	2916	reviewed	G-protein coupled receptor
O15305	BXGT004152	Phosphomannomutase 2	5373	reviewed	Enzyme
O15460	BXGT004172	Prolyl 4-hydroxylase subunit alpha-2	8974	reviewed
O60488	BXGT004878	Long-chain-fatty-acid--CoA ligase 4	2182	reviewed	Enzyme
O60568	BXGT004885	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3	8985	reviewed	Enzyme
O60840	BXGT004901	Voltage-dependent L-type calcium channel subunit alpha-1F	778	reviewed	Ion channel
O75116	BXGT005100	Rho-associated protein kinase 2	9475	reviewed	Kinase
O75530	BXGT005135	Polycomb protein EED	8726	reviewed
O75746	BXGT005148	Calcium-binding mitochondrial carrier protein Aralar1	8604	reviewed	Transporter
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
O95255	BXGT005363	Multidrug resistance-associated protein 6	368	reviewed	Transporter
P00480	BXGT005551	Ornithine carbamoyltransferase, mitochondrial	5009	reviewed
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01111	BXGT005731	GTPase NRas	4893	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02458	BXGT005879	Collagen alpha-1(II) chain	1280	reviewed
P02462	BXGT005881	Collagen alpha-1(IV) chain	1282	reviewed
P02724	BXGT005934	Glycophorin-A	2993	reviewed
P02774	BXGT005959	Vitamin D-binding protein	2638	reviewed	Transporter
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04181	BXGT006165	Ornithine aminotransferase, mitochondrial	4942	reviewed	Enzyme
P05156	BXGT006329	Complement factor I	3426	reviewed
P05412	BXGT006354	Transcription factor AP-1	3725	reviewed	Transcription factor
P07237	BXGT006576	Protein disulfide-isomerase	5034	reviewed
P08047	BXGT006720	Transcription factor Sp1	6667	reviewed	Nucleic acid binding
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08172	BXGT006737	Muscarinic acetylcholine receptor M2	1129	reviewed	G-protein coupled receptor
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08603	BXGT006798	Complement factor H	3075	reviewed
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09668	BXGT006914	Pro-cathepsin H	1512	reviewed	Enzyme
P09914	BXGT006940	Interferon-induced protein with tetratricopeptide repeats 1	3434	reviewed
P09936	BXGT006943	Ubiquitin carboxyl-terminal hydrolase isozyme L1	7345	reviewed	Enzyme
P0DN79	BXGT007511	Cystathionine beta-synthase-like protein	875	reviewed
P10276	BXGT007553	Retinoic acid receptor alpha	5914	reviewed	Nuclear receptor
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10826	BXGT007622	Retinoic acid receptor beta	5915	reviewed	Nuclear receptor
P10828	BXGT007624	Thyroid hormone receptor beta	7068	reviewed	Nuclear receptor
P11308	BXGT007684	Transcriptional regulator ERG	2078	reviewed	Transcription factor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P12235	BXGT007774	ADP/ATP translocase 1	291	reviewed	Transporter
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P12931	BXGT007859	Proto-oncogene tyrosine-protein kinase Src	6714	reviewed	Kinase
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14679	BXGT008039	Tyrosinase	7299	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15104	BXGT008081	Glutamine synthetase	2752	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P17707	BXGT008331	S-adenosylmethionine decarboxylase proenzyme	262	reviewed	Enzyme
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18146	BXGT008384	Early growth response protein 1	1958	reviewed	Nucleic acid binding
P20292	BXGT008561	Arachidonate 5-lipoxygenase-activating protein	241	reviewed	Enzyme
P20309	BXGT008562	Muscarinic acetylcholine receptor M3	1131	reviewed	G-protein coupled receptor
P20930	BXGT008616	Filaggrin	2312	reviewed	Cellular structure
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P21675	BXGT008678	Transcription initiation factor TFIID subunit 1	6872	reviewed	Kinase
P21728	BXGT008686	D(1A) dopamine receptor	1812	reviewed	G-protein coupled receptor
P22413	BXGT008764	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	5167	reviewed	Enzyme
P22894	BXGT008815	Neutrophil collagenase	4317	reviewed	Enzyme
P25100	BXGT009017	Alpha-1D adrenergic receptor	146	reviewed	G-protein coupled receptor
P26640	BXGT009123	Valine--tRNA ligase	7407	reviewed
P27635	BXGT009194	60S ribosomal protein L10	6134	reviewed	Nucleic acid binding
P27986	BXGT009216	Phosphatidylinositol 3-kinase regulatory subunit alpha	5295	reviewed	Kinase
P28300	BXGT009243	Protein-lysine 6-oxidase	4015	reviewed
P28347	BXGT009257	Transcriptional enhancer factor TEF-1	7003	reviewed	Transcription factor
P28676	BXGT009284	Grancalcin	25801	reviewed
P29274	BXGT009327	Adenosine receptor A2a	135	reviewed	G-protein coupled receptor
P29317	BXGT009331	Ephrin type-A receptor 2	1969	reviewed	Kinase
P29400	BXGT009343	Collagen alpha-5(IV) chain	1287	reviewed
P30533	BXGT009434	Alpha-2-macroglobulin receptor-associated protein	4043	reviewed
P31323	BXGT009521	cAMP-dependent protein kinase type II-beta regulatory subunit	5577	reviewed
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35520	BXGT009842	Cystathionine beta-synthase	875	reviewed
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P36507	BXGT009923	Dual specificity mitogen-activated protein kinase kinase 2	5605	reviewed	Kinase
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P36955	BXGT009946	Pigment epithelium-derived factor	5176	reviewed	Enzyme modulator
P39060	BXGT010088	Collagen alpha-1(XVIII) chain	80781	reviewed
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41229	BXGT010239	Lysine-specific demethylase 5C	8242	reviewed
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42858	BXGT010341	Huntingtin	3064	reviewed
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P48058	BXGT010614	Glutamate receptor 4	2893	reviewed	Ion channel
P48167	BXGT010621	Glycine receptor subunit beta	2743	reviewed	Ion channel
P48506	BXGT010635	Glutamate--cysteine ligase catalytic subunit	2729	reviewed	Enzyme
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49902	BXGT010758	Cytosolic purine 5'-nucleotidase	22978	reviewed	Enzyme
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P51572	BXGT010859	B-cell receptor-associated protein 31	10134	reviewed	Transporter
P51884	BXGT010903	Lumican	4060	reviewed
P52732	BXGT010948	Kinesin-like protein KIF11	3832	reviewed	Cellular structure
P53667	BXGT011008	LIM domain kinase 1	3984	reviewed	Kinase
P53673	BXGT011010	Beta-crystallin A4	1413	reviewed
P54710	BXGT011070	Sodium/potassium-transporting ATPase subunit gamma	486	reviewed	Transporter
P54829	BXGT011085	Tyrosine-protein phosphatase non-receptor type 5	84867	reviewed
P54886	BXGT011092	Delta-1-pyrroline-5-carboxylate synthase	5832	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P61586	BXGT011375	Transforming protein RhoA	387	reviewed	Enzyme modulator
P78417	BXGT011843	Glutathione S-transferase omega-1	9446	reviewed
P78504	BXGT011844	Protein jagged-1	182	reviewed
P98160	BXGT012228	Basement membrane-specific heparan sulfate proteoglycan core protein	3339	reviewed	Enzyme modulator
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q01726	BXGT012610	Melanocyte-stimulating hormone receptor	4157	reviewed	G-protein coupled receptor
Q02750	BXGT012662	Dual specificity mitogen-activated protein kinase kinase 1	5604	reviewed	Kinase
Q02809	BXGT012674	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	5351	reviewed	Enzyme
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	4297	reviewed
Q03692	BXGT012735	Collagen alpha-1(X) chain	1300	reviewed	Extracellular structure
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q06124	BXGT012856	Tyrosine-protein phosphatase non-receptor type 11	5781	reviewed
Q06481	BXGT012878	Amyloid-like protein 2	334	reviewed	Enzyme modulator
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q07954	BXGT012950	Prolow-density lipoprotein receptor-related protein 1	4035	reviewed
Q12791	BXGT013264	Calcium-activated potassium channel subunit alpha-1	3778	reviewed	Ion channel
Q12830	BXGT013268	Nucleosome-remodeling factor subunit BPTF	2186	reviewed
Q12882	BXGT013276	Dihydropyrimidine dehydrogenase [NADP(+)]	1806	reviewed	Enzyme
Q13402	BXGT013348	Unconventional myosin-VIIa	4647	reviewed	Cellular structure
Q13467	BXGT013358	Frizzled-5	7855	reviewed	G-protein coupled receptor
Q13555	BXGT013375	Calcium/calmodulin-dependent protein kinase type II subunit gamma	818	reviewed	Kinase
Q13586	BXGT013380	Stromal interaction molecule 1	6786	reviewed
Q14004	BXGT013435	Cyclin-dependent kinase 13	8621	reviewed	Kinase
Q14118	BXGT013444	Dystroglycan	1605	reviewed	Receptor
Q14683	BXGT013500	Structural maintenance of chromosomes protein 1A	8243	reviewed
Q15067	BXGT013532	Peroxisomal acyl-coenzyme A oxidase 1	51	reviewed	Enzyme
Q15233	BXGT013552	Non-POU domain-containing octamer-binding protein	4841	reviewed	Nucleic acid binding
Q16620	BXGT013645	BDNF/NT-3 growth factors receptor	4915	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q5VWZ2	BXGT015892	Lysophospholipase-like protein 1	127018	reviewed
Q8IVA8	BXGT018342	Glutamate decarboxylase 1 (Brain, 67kDa)	2571	unreviewed
Q8IVL5	BXGT018346	Prolyl 3-hydroxylase 2	55214	reviewed	Extracellular structure
Q8NFD5	BXGT018560	AT-rich interactive domain-containing protein 1B	57492	reviewed
Q8WVQ1	BXGT018996	Soluble calcium-activated nucleotidase 1	124583	reviewed
Q8WW43	BXGT018998	Gamma-secretase subunit APH-1B	83464	reviewed	Enzyme modulator
Q8WWQ0	BXGT019003	PH-interacting protein	55023	reviewed	Epigenetic regulator
Q8WZ42	BXGT019023	Titin	7273	reviewed	Kinase
Q8WZA1	BXGT019024	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	55624	reviewed
Q92743	BXGT019368	Serine protease HTRA1	5654	reviewed	Enzyme
Q92772	BXGT019371	Cyclin-dependent kinase-like 2	8999	reviewed	Kinase
Q92781	BXGT019372	Retinol dehydrogenase 5	5959	reviewed	Enzyme
Q92834	BXGT019381	X-linked retinitis pigmentosa GTPase regulator	6103	reviewed
Q96AT9	BXGT019619	Ribulose-phosphate 3-epimerase	6120	reviewed
Q96LW4	BXGT019695	DNA-directed primase/polymerase protein	201973	reviewed
Q96NI6	BXGT019699	Leucine-rich repeat and fibronectin type-III domain-containing protein 5	145581	reviewed
Q96Q11	BXGT019713	CCA tRNA nucleotidyltransferase 1, mitochondrial	51095	reviewed
Q99259	BXGT019915	Glutamate decarboxylase 1	2571	reviewed	Enzyme
Q99972	BXGT019979	Myocilin	4653	reviewed	Cellular structure
Q9BY41	BXGT020180	Histone deacetylase 8	55869	reviewed	Epigenetic regulator
Q9GZR1	BXGT020423	Sentrin-specific protease 6	26054	reviewed	Enzyme
Q9H0F7	BXGT020435	ADP-ribosylation factor-like protein 6	84100	reviewed
Q9H3S7	BXGT020467	Tyrosine-protein phosphatase non-receptor type 23	25930	reviewed
Q9H4B4	BXGT020474	Serine/threonine-protein kinase PLK3	1263	reviewed	Kinase
Q9H6X2	BXGT020486	Anthrax toxin receptor 1	84168	reviewed	Receptor
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9HCR9	BXGT020537	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	50940	reviewed
Q9HD42	BXGT020543	Charged multivesicular body protein 1a	5119	reviewed
Q9NRF2	BXGT021185	SH2B adapter protein 1	25970	reviewed
Q9NSY1	BXGT021209	BMP-2-inducible protein kinase	55589	reviewed	Kinase
Q9NWB1	BXGT021231	RNA binding protein fox-1 homolog 1	54715	reviewed	Nucleic acid binding
Q9NWM8	BXGT021233	Peptidyl-prolyl cis-trans isomerase FKBP14	55033	reviewed
Q9NX14	BXGT021242	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial	54539	reviewed	Enzyme
Q9NXG6	BXGT021246	Transmembrane prolyl 4-hydroxylase	54681	reviewed
Q9NYR8	BXGT021261	Retinol dehydrogenase 8	50700	reviewed	Enzyme
Q9UGL1	BXGT021685	Lysine-specific demethylase 5B	10765	reviewed	Epigenetic regulator
Q9UHX1	BXGT021707	Poly(U)-binding-splicing factor PUF60	22827	reviewed
Q9ULC6	BXGT021759	Protein-arginine deiminase type-1	29943	reviewed
Q9ULV0	BXGT021763	Unconventional myosin-Vb	4645	reviewed	Cellular structure
Q9Y4I1	BXGT022278	Unconventional myosin-Va	4644	reviewed	Cellular structure
Q01955	BXGT023255	Collagen alpha-3(IV) chain	1285	reviewed
P17535	BXGT023437	Transcription factor jun-D	3727	reviewed	Transcription factor
P53539	BXGT023438	Protein fosB	2354	reviewed	Transcription factor
Q53GS7	BXGT023762	Nucleoporin GLE1	2733	reviewed	Transporter
Q15583	BXGT024027	Homeobox protein TGIF1	7050	reviewed	Enzyme
Q9H694	BXGT024116	Protein bicaudal C homolog 1	80114	reviewed	Transporter
Q9H9S5	BXGT024623	Fukutin-related protein	79147	reviewed
Q96L73	BXGT024676	Histone-lysine N-methyltransferase, H3 lysine-36 specific	64324	reviewed	Epigenetic regulator
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
Q05086	BXGT025648	Ubiquitin-protein ligase E3A	7337	reviewed
Q9P121	BXGT025711	Neurotrimin	50863	reviewed
P35250	BXGT025854	Replication factor C subunit 2	5982	reviewed	Enzyme
Q9UQE7	BXGT025899	Structural maintenance of chromosomes protein 3	9126	reviewed
P58215	BXGT026106	Lysyl oxidase homolog 3	84695	reviewed
P07315	BXGT026109	Gamma-crystallin C	1420	reviewed
P07320	BXGT026150	Gamma-crystallin D	1421	reviewed
P43320	BXGT026151	Beta-crystallin B2	1415	reviewed
P02489	BXGT026168	Alpha-crystallin A chain	1409	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}