adisease

Showing entry for Severe myopia

General Disease Information
BXGD Id	BXGD006169
Disease Name	Severe myopia
Disease CUI Id	C0271183
MeSH Codes	C11
Disease Class Name	Eye Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000478
Human Phenotype Ontology Term	Abnormality of the eye
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00222	BXGT003899	Metabotropic glutamate receptor 8	2918	reviewed	G-protein coupled receptor
O15303	BXGT004150	Metabotropic glutamate receptor 6	2916	reviewed	G-protein coupled receptor
O15460	BXGT004172	Prolyl 4-hydroxylase subunit alpha-2	8974	reviewed
O60313	BXGT004871	Dynamin-like 120 kDa protein, mitochondrial	4976	reviewed	Enzyme modulator
O60840	BXGT004901	Voltage-dependent L-type calcium channel subunit alpha-1F	778	reviewed	Ion channel
O75223	BXGT005106	Gamma-glutamylcyclotransferase	79017	reviewed
O95271	BXGT005369	Poly [ADP-ribose] polymerase tankyrase-1	8658	reviewed
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02458	BXGT005879	Collagen alpha-1(II) chain	1280	reviewed
P02511	BXGT005885	Alpha-crystallin B chain	1410	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P05412	BXGT006354	Transcription factor AP-1	3725	reviewed	Transcription factor
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08100	BXGT006725	Rhodopsin	6010	reviewed	G-protein coupled receptor
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08581	BXGT006794	Hepatocyte growth factor receptor	4233	reviewed	Kinase
P08833	BXGT006827	Insulin-like growth factor-binding protein 1	3484	reviewed	Enzyme modulator
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P10745	BXGT007608	Retinol-binding protein 3	5949	reviewed
P10826	BXGT007622	Retinoic acid receptor beta	5915	reviewed	Nuclear receptor
P11229	BXGT007676	Muscarinic acetylcholine receptor M1	1128	reviewed	G-protein coupled receptor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11488	BXGT007713	Guanine nucleotide-binding protein G(t) subunit alpha-1	2779	reviewed	Enzyme modulator
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P12643	BXGT007830	Bone morphogenetic protein 2	650	reviewed	Signaling
P14060	BXGT007978	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	3283	reviewed	Enzyme
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P17707	BXGT008331	S-adenosylmethionine decarboxylase proenzyme	262	reviewed	Enzyme
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P18146	BXGT008384	Early growth response protein 1	1958	reviewed	Nucleic acid binding
P21860	BXGT008698	Receptor tyrosine-protein kinase erbB-3	2065	reviewed	Kinase
P29274	BXGT009327	Adenosine receptor A2a	135	reviewed	G-protein coupled receptor
P30533	BXGT009434	Alpha-2-macroglobulin receptor-associated protein	4043	reviewed
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35913	BXGT009879	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	5158	reviewed
P36955	BXGT009946	Pigment epithelium-derived factor	5176	reviewed	Enzyme modulator
P39060	BXGT010088	Collagen alpha-1(XVIII) chain	80781	reviewed
P40394	BXGT010178	Alcohol dehydrogenase class 4 mu/sigma chain	131	reviewed	Enzyme
P41440	BXGT010261	Folate transporter 1	6573	reviewed	Transporter
P51157	BXGT010838	Ras-related protein Rab-28	9364	reviewed
P51884	BXGT010903	Lumican	4060	reviewed
P52788	BXGT010953	Spermine synthase	6611	reviewed
P53673	BXGT011010	Beta-crystallin A4	1413	reviewed
P61006	BXGT011345	Ras-related protein Rab-8A	4218	reviewed
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q00604	BXGT012538	Norrin	4693	reviewed
Q02809	BXGT012674	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	5351	reviewed	Enzyme
Q06828	BXGT012893	Fibromodulin	2331	reviewed
Q12791	BXGT013264	Calcium-activated potassium channel subunit alpha-1	3778	reviewed	Ion channel
Q12830	BXGT013268	Nucleosome-remodeling factor subunit BPTF	2186	reviewed
Q15256	BXGT013553	Receptor-type tyrosine-protein phosphatase R	5801	reviewed
Q15835	BXGT013606	Rhodopsin kinase	6011	reviewed	Kinase
Q16678	BXGT013656	Cytochrome P450 1B1	1545	reviewed	Enzyme
Q2MKA7	BXGT014140	R-spondin-1	284654	reviewed
Q8IVL5	BXGT018346	Prolyl 3-hydroxylase 2	55214	reviewed	Extracellular structure
Q92834	BXGT019381	X-linked retinitis pigmentosa GTPase regulator	6103	reviewed
Q96AT9	BXGT019619	Ribulose-phosphate 3-epimerase	6120	reviewed
Q96LW4	BXGT019695	DNA-directed primase/polymerase protein	201973	reviewed
Q99972	BXGT019979	Myocilin	4653	reviewed	Cellular structure
Q9H4B4	BXGT020474	Serine/threonine-protein kinase PLK3	1263	reviewed	Kinase
Q9NSY1	BXGT021209	BMP-2-inducible protein kinase	55589	reviewed	Kinase
Q9NWB1	BXGT021231	RNA binding protein fox-1 homolog 1	54715	reviewed	Nucleic acid binding
Q9NYR8	BXGT021261	Retinol dehydrogenase 8	50700	reviewed	Enzyme
Q7Z3S7	BXGT022658	Voltage-dependent calcium channel subunit alpha-2/delta-4	93589	reviewed	Ion channel
Q15583	BXGT024027	Homeobox protein TGIF1	7050	reviewed	Enzyme
Q9H694	BXGT024116	Protein bicaudal C homolog 1	80114	reviewed	Transporter
P58215	BXGT026106	Lysyl oxidase homolog 3	84695	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}