Showing entry for Mitogen-activated protein kinase kinase kinase 13


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004583
Protein NameMitogen-activated protein kinase kinase kinase 13
Uniport IdO43283
GeneMAP3K13
Gene Id9175
DomainPkinase_Tyr
Pfam PF07714  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007256 activation of JNKK activity
Biological Process GO:0007257 activation of JUN kinase activity
Biological Process GO:0000186 activation of MAPKK activity
Biological Process GO:0007254 JNK cascade
Biological Process GO:0018105 peptidyl-serine phosphorylation
Biological Process GO:0045773 positive regulation of axon extension
Biological Process GO:1905492 positive regulation of branching morphogenesis of a nerve
Biological Process GO:0014042 positive regulation of neuron maturation
Biological Process GO:0150012 positive regulation of neuron projection arborization
Biological Process GO:0051092 positive regulation of NF-kappaB transcription factor activity
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
molecular function GO:0005524 ATP binding
molecular function GO:0019899 enzyme binding
molecular function GO:0042802 identical protein binding
molecular function GO:0106137 IkappaB kinase complex binding
molecular function GO:0004706 JUN kinase kinase kinase activity
molecular function GO:0004709 MAP kinase kinase kinase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004672 protein kinase activity
molecular function GO:0019901 protein kinase binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0496956 BXGD009052 Neoplasm of uncertain or unknown behavior of breast Neoplasms; Skin and Connective Tissue Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0858252 BXGD011172 Breast adenocarcinoma Neoplasms; Skin and Connective Tissue Diseases
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein