Showing entry for Cleavage and polyadenylation specificity factor subunit 5


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT004627
Protein NameCleavage and polyadenylation specificity factor subunit 5
Uniport IdO43809
GeneNUDT21
Gene Id11051
DomainNUDIX_2
Pfam PF13869  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03015 mRNA surveillance pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030154 cell differentiation
Biological Process GO:1990120 messenger ribonucleoprotein complex assembly
Biological Process GO:0031124 mRNA 3'-end processing
Biological Process GO:0110104 mRNA alternative polyadenylation
Biological Process GO:0006378 mRNA polyadenylation
Biological Process GO:0006397 mRNA processing
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0031439 positive regulation of mRNA cleavage
Biological Process GO:1900365 positive regulation of mRNA polyadenylation
Biological Process GO:2000975 positive regulation of pro-B cell differentiation
Biological Process GO:2000738 positive regulation of stem cell differentiation
Biological Process GO:0010608 posttranscriptional regulation of gene expression
Biological Process GO:0098789 pre-mRNA cleavage required for polyadenylation
Biological Process GO:0051290 protein heterotetramerization
Biological Process GO:0051262 protein tetramerization
Biological Process GO:0006369 termination of RNA polymerase II transcription
molecular function GO:0017091 AU-rich element binding
molecular function GO:0003682 chromatin binding
molecular function GO:0042826 histone deacetylase binding
molecular function GO:0016787 hydrolase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0035925 mRNA 3'-UTR AU-rich region binding
molecular function GO:0003729 mRNA binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0003723 RNA binding
cellular component GO:0034451 centriolar satellite
cellular component GO:0005813 centrosome
cellular component GO:0005737 cytoplasm
cellular component GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
cellular component GO:0005849 mRNA cleavage factor complex
cellular component GO:0016604 nuclear body
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0042382 paraspeckles
Reactome
Pathway Id Pathway Name
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72172 mRNA Splicing
R-HSA-72187 mRNA 3'-end processing
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-73856 RNA Polymerase II Transcription Termination
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-75067 Processing of Capped Intronless Pre-mRNA
R-HSA-77595 Processing of Intronless Pre-mRNAs
R-HSA-8953854 Metabolism of RNA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0023418 BXGD001642 leukemia Neoplasms
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0555198 BXGD009432 Malignant Glioma Neoplasms
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1997217 BXGD016859 Low grade glioma Neoplasms
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4722099 BXGD023789 High grade glioma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein