Showing entry for Sterol O-acyltransferase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005162
Protein NameSterol O-acyltransferase 2
Uniport IdO75908
GeneSOAT2
Gene Id8435
DomainMBOAT
Pfam PF03062  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00100 Steroid biosynthesis
5. Organismal Systems 5.4 Digestive system hsa04979 Cholesterol metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0033344 cholesterol efflux
Biological Process GO:0034435 cholesterol esterification
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0030299 intestinal cholesterol absorption
Biological Process GO:0034383 low-density lipoprotein particle clearance
Biological Process GO:0010742 macrophage derived foam cell differentiation
Biological Process GO:0034379 very-low-density lipoprotein particle assembly
molecular function GO:0015485 cholesterol binding
molecular function GO:0034736 cholesterol O-acyltransferase activity
molecular function GO:0000062 fatty-acyl-CoA binding
molecular function GO:0008374 O-acyltransferase activity
molecular function GO:0004772 sterol O-acyltransferase activity
molecular function GO:0016746 transferase activity, transferring acyl groups
cellular component GO:0005903 brush border
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
Reactome
Pathway Id Pathway Name
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-382551 Transport of small molecules
R-HSA-8964038 LDL clearance
R-HSA-8964043 Plasma lipoprotein clearance
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027726 BXGD002030 Nephrotic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0043208 BXGD003039 Wolman Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0240225 BXGD005025 Liver mass
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C1561643 BXGD013363 Chronic Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2936797 BXGD018139 Acid cholesteryl ester hydrolase deficiency, type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0001962 Hesperetin 302.28
BXGC0008819 Cycloartocarpesin 352.34
BXGC0021537 Cudraflavanone D 424.19
BXGC0022426 Cudraxanthone L 396.16
BXGC0024168 Macluraxanthone B 396.16
BXGC0029095 Isocudraniaxanthone B 342.11
BXGC0029160 Cudraxanthone C 410.17
BXGC0032049 Isobutylshikonin 358.14
BXGC0032122 manassantin B 716.32
BXGC0032798 Shikonin 288.1
BXGC0034166 [(1R)-1-(5,8-Dihydroxy-1,4-Dioxonaphthalen-2-Yl)-4-Methylpent-3-Enyl] Propanoate 344.13
BXGC0034227 Beta-Hydroxyisovalerylshikonin 388.15
BXGC0034759 1-(3,4-Dimethoxyphenyl)-2-[4-[(2S,3R,4R,5S)-5-[4-[1-(3,4-Dimethoxyphenyl)-1-Hydroxypropan-2-Yl]Oxy-3-Methoxyphenyl]-3,4-Dimethyloxolan-2-Yl]-2-Methoxyphenoxy]Propan-1-Ol 732.35
BXGC0035663 Cudraflavanone A 422.17
BXGC0039761 (S)-5,7,7'-Trihydroxy-8-(3-Hydroxy-3-Methylbutyl)-2',2'-Dimethyl-2,6'-Bichroman-4-One 440.18
BXGC0040114 Acetylshikonin 330.11
BXGC0040708 1,3,7-Trihydroxy-4-(1,1-Dimethyl-2-Propenyl)-5,6-(2,2-Dimethylchromeno) Xanthone 394.14
BXGC0041194 [(1R)-1-(5,8-Dihydroxy-1,4-Dioxonaphthalen-2-Yl)-4-Methylpent-3-Enyl] Butanoate 358.14
BXGC0042465 Cudraxanthone D 410.17
BXGC0042482 [(1R)-1-(5,8-Dihydroxy-1,4-Dioxonaphthalen-2-Yl)-4-Methylpent-3-Enyl] 3-Methylbutanoate 372.16
BXGC0042565 Cudraxanthone M 396.16
BXGC0045005 4-(2,4-Dimethylpent-3-En-2-Yl)-1,6,7-Trihydroxy-3-Methylxanthen-9-One 354.15
BXGC0045212 n.a 550.33
BXGC0045253 [(1R)-1-(5,8-Dihydroxy-1,4-Dioxonaphthalen-2-Yl)-4-Methylpent-3-Enyl] Pent-4-Enoate 370.14
BXGC0046519 [(1R)-1-(5,8-dihydroxy-1,4-dioxo-naphthalen-2-yl)-4-methyl-pent-3-enyl] Benzoate 392.13
BXGC0046521 [(1R)-1-(5,8-dihydroxy-1,4-dioxo-naphthalen-2-yl)-4-methyl-pent-3-enyl] Pentanoate 372.16
BXGC0050880 Cudraflavone B 420.16
BXGC0053005 Manassantin B 716.32
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein