Showing entry for Nephrotic Syndrome


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD002030
Disease NameNephrotic Syndrome
Disease CUI IdC0027726
MeSH Codes C13   C12  
Disease Class NameFemale Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000119  
Human Phenotype Ontology TermAbnormality of the genitourinary system
Disease Ontology Id DOID:630   DOID:7  
Disease Ontology Class Namegenetic disease; disease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00429 BXGT003919 Dynamin-1-like protein 10059 reviewed Enzyme modulator
O14791 BXGT004101 Apolipoprotein L1 8542 reviewed Transporter
O15123 BXGT004130 Angiopoietin-2 285 reviewed Signaling
O15230 BXGT004138 Laminin subunit alpha-5 3911 reviewed Enzyme modulator
O15305 BXGT004152 Phosphomannomutase 2 5373 reviewed Enzyme
O15553 BXGT004181 Pyrin 4210 reviewed
O43639 BXGT004608 Cytoplasmic protein NCK2 8440 reviewed
O43707 BXGT004616 Alpha-actinin-4 81 reviewed
O75908 BXGT005162 Sterol O-acyltransferase 2 8435 reviewed Enzyme
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase 8654 reviewed
O95445 BXGT005381 Apolipoprotein M 55937 reviewed
O95470 BXGT005382 Sphingosine-1-phosphate lyase 1 8879 reviewed
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P00736 BXGT005632 Complement C1r subcomponent 715 reviewed Enzyme
P00740 BXGT005634 Coagulation factor IX 2158 reviewed Enzyme
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P00750 BXGT005642 Tissue-type plasminogen activator 5327 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P00813 BXGT005667 Adenosine deaminase 100 reviewed Enzyme
P01008 BXGT005713 Antithrombin-III 462 reviewed Enzyme modulator
P01009 BXGT005714 Alpha-1-antitrypsin 5265 reviewed Enzyme modulator
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01023 BXGT005718 Alpha-2-macroglobulin 2 reviewed Enzyme modulator
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01034 BXGT005721 Cystatin-C 1471 reviewed
P01130 BXGT005735 Low-density lipoprotein receptor 3949 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01270 BXGT005746 Parathyroid hormone 5741 reviewed
P01275 BXGT005747 Glucagon 2641 reviewed
P01308 BXGT005749 Insulin 3630 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01909 BXGT005815 HLA class II histocompatibility antigen, DQ alpha 1 chain 3117 reviewed Immune response
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P01920 BXGT005817 HLA class II histocompatibility antigen, DQ beta 1 chain 3119 reviewed Immune response
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02462 BXGT005881 Collagen alpha-1(IV) chain 1282 reviewed
P02647 BXGT005908 Apolipoprotein A-I 335 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02671 BXGT005914 Fibrinogen alpha chain 2243 reviewed
P02751 BXGT005943 Fibronectin 2335 reviewed Signaling
P02766 BXGT005953 Transthyretin 7276 reviewed Transporter
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02787 BXGT005962 Serotransferrin 7018 reviewed Enzyme
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03886 BXGT006108 NADH-ubiquinone oxidoreductase chain 1 4535 reviewed Enzyme
P03905 BXGT006113 NADH-ubiquinone oxidoreductase chain 4 4538 reviewed Enzyme
P03915 BXGT006114 NADH-ubiquinone oxidoreductase chain 5 4540 reviewed Enzyme
P03923 BXGT006115 NADH-ubiquinone oxidoreductase chain 6 4541 reviewed
P03952 BXGT006118 Plasma kallikrein 3818 reviewed Enzyme
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04054 BXGT006136 Phospholipase A2 5319 reviewed Enzyme
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P04180 BXGT006164 Phosphatidylcholine-sterol acyltransferase 3931 reviewed Enzyme
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04792 BXGT006264 Heat shock protein beta-1 3315 reviewed
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06280 BXGT006433 Alpha-galactosidase A 2717 reviewed
P06396 BXGT006435 Gelsolin 2934 reviewed Cellular structure
P06727 BXGT006485 Apolipoprotein A-IV 337 reviewed
P06729 BXGT006486 T-cell surface antigen CD2 914 reviewed
P06858 BXGT006515 Lipoprotein lipase 4023 reviewed Enzyme
P07711 BXGT006661 Cathepsin L1 1514 reviewed Enzyme
P07858 BXGT006689 Cathepsin B 1508 reviewed Enzyme
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08235 BXGT006751 Mineralocorticoid receptor 4306 reviewed Nuclear receptor
P08397 BXGT006768 Porphobilinogen deaminase 3145 reviewed Enzyme
P08572 BXGT006791 Collagen alpha-2(IV) chain 1284 reviewed
P08603 BXGT006798 Complement factor H 3075 reviewed
P08684 BXGT006812 Cytochrome P450 3A4 1576 reviewed Enzyme
P08842 BXGT006830 Steryl-sulfatase 412 reviewed Enzyme
P09038 BXGT006851 Fibroblast growth factor 2 2247 reviewed Signaling
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09871 BXGT006932 Complement C1s subcomponent 716 reviewed Enzyme
P09917 BXGT006941 Arachidonate 5-lipoxygenase 240 reviewed Enzyme
P09960 BXGT006952 Leukotriene A-4 hydrolase 4048 reviewed
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10646 BXGT007598 Tissue factor pathway inhibitor 7035 reviewed Enzyme modulator
P10909 BXGT007630 Clusterin 1191 reviewed
P11597 BXGT007727 Cholesteryl ester transfer protein 1071 reviewed
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13726 BXGT007950 Tissue factor 2152 reviewed Receptor
P14174 BXGT007991 Macrophage migration inhibitory factor 4282 reviewed
P15056 BXGT008075 Serine/threonine-protein kinase B-raf 673 reviewed Kinase
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16333 BXGT008219 Cytoplasmic protein NCK1 4690 reviewed
P16671 BXGT008255 Platelet glycoprotein 4 948 reviewed Receptor
P16871 BXGT008269 Interleukin-7 receptor subunit alpha 3575 reviewed Receptor
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 2321 reviewed Kinase
P18827 BXGT008427 Syndecan-1 6382 reviewed Extracellular structure
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P20339 BXGT008565 Ras-related protein Rab-5A 5868 reviewed
P20711 BXGT008594 Aromatic-L-amino-acid decarboxylase 1644 reviewed
P20815 BXGT008604 Cytochrome P450 3A5 1577 reviewed Enzyme
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P23468 BXGT008870 Receptor-type tyrosine-protein phosphatase delta 5789 reviewed Enzyme
P23528 BXGT008879 Cofilin-1 1072 reviewed
P24385 BXGT008965 G1/S-specific cyclin-D1 595 reviewed Enzyme modulator
P24752 BXGT008993 Acetyl-CoA acetyltransferase, mitochondrial 38 reviewed Enzyme
P25101 BXGT009018 Endothelin-1 receptor 1909 reviewed G-protein coupled receptor
P27797 BXGT009206 Calreticulin 811 reviewed Calcium-binding protein
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P29400 BXGT009343 Collagen alpha-5(IV) chain 1287 reviewed
P29460 BXGT009348 Interleukin-12 subunit beta 3593 reviewed Signaling
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P30405 BXGT009423 Peptidyl-prolyl cis-trans isomerase F, mitochondrial 10105 reviewed
P30556 BXGT009441 Type-1 angiotensin II receptor 185 reviewed G-protein coupled receptor
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31785 BXGT009577 Cytokine receptor common subunit gamma 3561 reviewed Signaling
P33261 BXGT009707 Cytochrome P450 2C19 1557 reviewed
P33681 BXGT009739 T-lymphocyte activation antigen CD80 941 reviewed
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35579 BXGT009852 Myosin-9 4627 reviewed
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P37088 BXGT009961 Amiloride-sensitive sodium channel subunit alpha 6337 reviewed Ion channel
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43403 BXGT010385 Tyrosine-protein kinase ZAP-70 7535 reviewed Kinase
P46108 BXGT010509 Adapter molecule crk 1398 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P46940 BXGT010556 Ras GTPase-activating-like protein IQGAP1 8826 reviewed Enzyme modulator
P48048 BXGT010610 ATP-sensitive inward rectifier potassium channel 1 3758 reviewed Ion channel
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49137 BXGT010680 MAP kinase-activated protein kinase 2 9261 reviewed Kinase
P49917 BXGT010765 DNA ligase 4 3981 reviewed
P51168 BXGT010842 Amiloride-sensitive sodium channel subunit beta 6338 reviewed Ion channel
P51617 BXGT010868 Interleukin-1 receptor-associated kinase 1 3654 reviewed Kinase
P51843 BXGT010897 Nuclear receptor subfamily 0 group B member 1 190 reviewed Nuclear receptor
P52565 BXGT010933 Rho GDP-dissociation inhibitor 1 396 reviewed Enzyme modulator
P55087 BXGT011105 Aquaporin-4 361 reviewed Ion channel
P56192 BXGT011149 Methionine--tRNA ligase, cytoplasmic 4141 reviewed
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61626 BXGT011382 Lysozyme C 4069 reviewed
P61769 BXGT011383 Beta-2-microglobulin 567 reviewed Immune response
P62491 BXGT011430 Ras-related protein Rab-11A 8766 reviewed
P63000 BXGT011481 Ras-related C3 botulinum toxin substrate 1 5879 reviewed Enzyme modulator
P63104 BXGT011499 14-3-3 protein zeta/delta 7534 reviewed Chaperone
P80365 BXGT011895 Corticosteroid 11-beta-dehydrogenase isozyme 2 3291 reviewed Enzyme
P98155 BXGT012226 Very low-density lipoprotein receptor 7436 reviewed
P98164 BXGT012230 Low-density lipoprotein receptor-related protein 2 4036 reviewed
Q01726 BXGT012610 Melanocyte-stimulating hormone receptor 4157 reviewed G-protein coupled receptor
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q04760 BXGT012782 Lactoylglutathione lyase 2739 reviewed
Q05655 BXGT012832 Protein kinase C delta type 5580 reviewed Kinase
Q12965 BXGT013285 Unconventional myosin-Ie 4643 reviewed Cellular structure
Q13093 BXGT013310 Platelet-activating factor acetylhydrolase 7941 reviewed Enzyme
Q13155 BXGT013320 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 7965 reviewed
Q13233 BXGT013330 Mitogen-activated protein kinase kinase kinase 1 4214 reviewed Kinase
Q13285 BXGT013335 Steroidogenic factor 1 2516 reviewed Nuclear receptor
Q13451 BXGT013356 Peptidyl-prolyl cis-trans isomerase FKBP5 2289 reviewed Enzyme
Q14108 BXGT013440 Lysosome membrane protein 2 950 reviewed Receptor
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16827 BXGT013675 Receptor-type tyrosine-protein phosphatase O 5800 reviewed
Q5Y7D3 BXGT015912 HLA class II histocompatibility antigen DQ beta chain 3119 unreviewed
Q63HR2 BXGT016085 Tensin-2 23371 reviewed
Q8NBP7 BXGT018541 Proprotein convertase subtilisin/kexin type 9 255738 reviewed Enzyme
Q92736 BXGT019367 Ryanodine receptor 2 6262 reviewed Ion channel
Q92769 BXGT019370 Histone deacetylase 2 3066 reviewed Epigenetic regulator
Q96D42 BXGT019636 Hepatitis A virus cellular receptor 1 26762 reviewed
Q96D53 BXGT019637 Atypical kinase COQ8B, mitochondrial 79934 reviewed Kinase
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q96S44 BXGT019738 EKC/KEOPS complex subunit TP53RK 112858 reviewed Kinase
Q99623 BXGT019941 Prohibitin-2 11331 reviewed
Q99784 BXGT019961 Noelin 10439 reviewed Cellular structure
Q99972 BXGT019979 Myocilin 4653 reviewed Cellular structure
Q9BYF1 BXGT020186 Angiotensin-converting enzyme 2 59272 reviewed Enzyme
Q9BZ95 BXGT020196 Histone-lysine N-methyltransferase NSD3 54904 reviewed Epigenetic regulator
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9H0F7 BXGT020435 ADP-ribosylation factor-like protein 6 84100 reviewed
Q9NZM3 BXGT021278 Intersectin-2 50618 reviewed Enzyme modulator
Q9P212 BXGT021297 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 51196 reviewed Enzyme
Q9Y251 BXGT022215 Heparanase 10855 reviewed Enzyme
Q9Y3D6 BXGT022257 Mitochondrial fission 1 protein 51024 reviewed
P52429 BXGT022667 Diacylglycerol kinase epsilon 8526 reviewed Enzyme
P00738 BXGT022874 Haptoglobin 3240 reviewed Enzyme
Q01955 BXGT023255 Collagen alpha-3(IV) chain 1285 reviewed
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
Q14678 BXGT023543 KN motif and ankyrin repeat domain-containing protein 1 23189 reviewed
Q63ZY3 BXGT023544 KN motif and ankyrin repeat domain-containing protein 2 25959 reviewed
P00395 BXGT023596 Cytochrome c oxidase subunit 1 4512 reviewed Enzyme
Q14657 BXGT024111 EKC/KEOPS complex subunit LAGE3 8270 reviewed
Q9NPF4 BXGT024113 Probable tRNA N6-adenosine threonylcarbamoyltransferase 55644 reviewed Enzyme
Q9Y6N5 BXGT024858 Sulfide:quinone oxidoreductase, mitochondrial 58472 reviewed
Q9BY76 BXGT025687 Angiopoietin-related protein 4 51129 reviewed Signaling
Q96SD1 BXGT025929 Protein artemis 64421 reviewed
P11836 BXGT025994 B-lymphocyte antigen CD20 931 reviewed Receptor
P19532 BXGT026110 Transcription factor E3 7030 reviewed
P00403 BXGT026137 Cytochrome c oxidase subunit 2 4513 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease