Showing entry for Complement component C8 beta chain


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT006611
Protein NameComplement component C8 beta chain
Uniport IdP07358
GeneC8B
Gene Id732
DomainLdl_recept_a; MACPF; TSP_1
Pfam PF00057   PF01823   PF00090  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04610 Complement and coagulation cascades
6. Human Diseases 6.4 Neurodegenerative diseases hsa05020 Prion diseases
6. Human Diseases 6.10 Infectious diseases: Parasitic hsa05146 Amoebiasis
6. Human Diseases 6.3 Immune diseases hsa05322 Systemic lupus erythematosus
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006956 complement activation
Biological Process GO:0006957 complement activation, alternative pathway
Biological Process GO:0006958 complement activation, classical pathway
Biological Process GO:0019835 cytolysis
Biological Process GO:0006955 immune response
Biological Process GO:0030449 regulation of complement activation
molecular function GO:0044877 protein-containing complex binding
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1903561 extracellular vesicle
cellular component GO:0016020 membrane
cellular component GO:0005579 membrane attack complex
Reactome
Pathway Id Pathway Name
R-HSA-166658 Complement cascade
R-HSA-166665 Terminal pathway of complement
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-977606 Regulation of Complement cascade
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003257 BXGD000189 Antibody Deficiency Syndrome Immune System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0025289 BXGD001851 Meningitis Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0030167 BXGD002188 Pachymeningitis Nervous System Diseases
C0085396 BXGD003162 Neisseriaceae Infections Infections
C0087031 BXGD003319 Juvenile-Onset Still Disease Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0272242 BXGD006330 Complement deficiency disease Immune System Diseases; Hemic and Lymphatic Diseases
C2676232 BXGD017328 Complement Component 6 Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3151080 BXGD018388 COMPLEMENT COMPONENT 8 DEFICIENCY, TYPE II
C3151082 BXGD018390 C8 deficiency
C3151083 BXGD018391 Recurrent Neisserial infections
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3714758 BXGD019431 Juvenile psoriatic arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4552091 BXGD023485 Polyarthritis, Juvenile, Rheumatoid Factor Negative Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C4704862 BXGD023681 Polyarthritis, Juvenile, Rheumatoid Factor Positive Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002616 Copper 63.55
BXGC0002682 Zinc 65.41
BXGC0018397 beta-1,4-mannan 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein