Showing entry for Juvenile arthritis


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD018994
Disease NameJuvenile arthritis
Disease CUI IdC3495559
MeSH Codes C17   C05   C20  
Disease Class NameSkin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
F7VJQ1 BXGT003310 Alternative prion protein 5621 reviewed
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00469 BXGT003926 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 5352 reviewed Enzyme
O14788 BXGT004100 Tumor necrosis factor ligand superfamily member 11 8600 reviewed Signaling
O15091 BXGT004125 Mitochondrial ribonuclease P catalytic subunit 9692 reviewed
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 8714 reviewed Transporter
O15455 BXGT004171 Toll-like receptor 3 7098 reviewed Receptor
O15553 BXGT004181 Pyrin 4210 reviewed
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O60858 BXGT004903 E3 ubiquitin-protein ligase TRIM13 10206 reviewed
O75369 BXGT005119 Filamin-B 2317 reviewed
O75923 BXGT005166 Dysferlin 8291 reviewed Transporter
O76054 BXGT005172 SEC14-like protein 2 23541 reviewed
O95150 BXGT005351 Tumor necrosis factor ligand superfamily member 15 9966 reviewed Signaling
P00813 BXGT005667 Adenosine deaminase 100 reviewed Enzyme
P01031 BXGT005720 Complement C5 727 reviewed Enzyme modulator
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01133 BXGT005736 Pro-epidermal growth factor 1950 reviewed
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01138 BXGT005738 Beta-nerve growth factor 4803 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01589 BXGT005773 Interleukin-2 receptor subunit alpha 3559 reviewed Receptor
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P01909 BXGT005815 HLA class II histocompatibility antigen, DQ alpha 1 chain 3117 reviewed Immune response
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P01920 BXGT005817 HLA class II histocompatibility antigen, DQ beta 1 chain 3119 reviewed Immune response
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02818 BXGT005969 Osteocalcin 632 reviewed
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P03956 BXGT006120 Interstitial collagenase 4312 reviewed Enzyme
P04003 BXGT006124 C4b-binding protein alpha chain 722 reviewed
P04040 BXGT006132 Catalase 847 reviewed Enzyme
P04156 BXGT006156 Major prion protein 5621 reviewed
P04271 BXGT006177 Protein S100-B 6285 reviewed Calcium-binding protein
P04440 BXGT006216 HLA class II histocompatibility antigen, DP beta 1 chain 3115 reviewed Immune response
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05109 BXGT006318 Protein S100-A8 6279 reviewed Calcium-binding protein
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P05412 BXGT006354 Transcription factor AP-1 3725 reviewed Transcription factor
P06681 BXGT006468 Complement C2 717 reviewed
P06702 BXGT006476 Protein S100-A9 6280 reviewed Calcium-binding protein
P07225 BXGT006572 Vitamin K-dependent protein S 5627 reviewed
P07358 BXGT006611 Complement component C8 beta chain 732 reviewed
P07550 BXGT006636 Beta-2 adrenergic receptor 154 reviewed G-protein coupled receptor
P07996 BXGT006710 Thrombospondin-1 7057 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08473 BXGT006773 Neprilysin 4311 reviewed Enzyme
P08514 BXGT006781 Integrin alpha-IIb 3674 reviewed
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C 5788 reviewed Enzyme
P08670 BXGT006810 Vimentin 7431 reviewed
P08887 BXGT006835 Interleukin-6 receptor subunit alpha 3570 reviewed Signaling
P09211 BXGT006869 Glutathione S-transferase P 2950 reviewed
P09327 BXGT006877 Villin-1 7429 reviewed Cellular structure
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P10144 BXGT007541 Granzyme B 3002 reviewed Enzyme
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10147 BXGT007543 C-C motif chemokine 3 6348 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P10646 BXGT007598 Tissue factor pathway inhibitor 7035 reviewed Enzyme modulator
P10745 BXGT007608 Retinol-binding protein 3 5949 reviewed
P10747 BXGT007609 T-cell-specific surface glycoprotein CD28 940 reviewed
P10809 BXGT007617 60 kDa heat shock protein, mitochondrial 3329 reviewed
P10909 BXGT007630 Clusterin 1191 reviewed
P11137 BXGT007656 Microtubule-associated protein 2 4133 reviewed
P11169 BXGT007664 Solute carrier family 2, facilitated glucose transporter member 3 6515 reviewed Transporter
P11226 BXGT007675 Mannose-binding protein C 4153 reviewed Receptor
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P12314 BXGT007798 High affinity immunoglobulin gamma Fc receptor I 2209 reviewed Cell adhesion
P13224 BXGT007890 Platelet glycoprotein Ib beta chain 2812 reviewed
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P14174 BXGT007991 Macrophage migration inhibitory factor 4282 reviewed
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P14784 BXGT008054 Interleukin-2 receptor subunit beta 3560 reviewed Receptor
P15309 BXGT008105 Prostatic acid phosphatase 55 reviewed Enzyme
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16109 BXGT008194 P-selectin 6403 reviewed
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16581 BXGT008245 E-selectin 6401 reviewed
P16871 BXGT008269 Interleukin-7 receptor subunit alpha 3575 reviewed Receptor
P17066 BXGT008279 Heat shock 70 kDa protein 6 3310 reviewed
P17706 BXGT008330 Tyrosine-protein phosphatase non-receptor type 2 5771 reviewed
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type 239 reviewed Enzyme
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P19320 BXGT008470 Vascular cell adhesion protein 1 7412 reviewed
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P21580 BXGT008666 Tumor necrosis factor alpha-induced protein 3 7128 reviewed Enzyme
P21589 BXGT008669 5'-nucleotidase 4907 reviewed Enzyme
P21980 BXGT008715 Protein-glutamine gamma-glutamyltransferase 2 7052 reviewed Enzyme
P22894 BXGT008815 Neutrophil collagenase 4317 reviewed Enzyme
P23297 BXGT008848 Protein S100-A1 6271 reviewed Calcium-binding protein
P25025 BXGT009006 C-X-C chemokine receptor type 2 3579 reviewed G-protein coupled receptor
P25440 BXGT009044 Bromodomain-containing protein 2 6046 reviewed Epigenetic regulator
P25788 BXGT009070 Proteasome subunit alpha type-3 5684 reviewed
P25963 BXGT009080 NF-kappa-B inhibitor alpha 4792 reviewed
P27487 BXGT009187 Dipeptidyl peptidase 4 1803 reviewed Enzyme
P28482 BXGT009263 Mitogen-activated protein kinase 1 5594 reviewed Kinase
P28562 BXGT009270 Dual specificity protein phosphatase 1 1843 reviewed
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29597 BXGT009367 Non-receptor tyrosine-protein kinase TYK2 7297 reviewed Kinase
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P30988 BXGT009491 Calcitonin receptor 799 reviewed G-protein coupled receptor
P31939 BXGT009584 Bifunctional purine biosynthesis protein PURH 471 reviewed Enzyme
P31941 BXGT009585 DNA dC->dU-editing enzyme APOBEC-3A 200315 reviewed
P32119 BXGT009600 Peroxiredoxin-2 7001 reviewed Enzyme
P34972 BXGT009779 Cannabinoid receptor 2 1269 reviewed G-protein coupled receptor
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35555 BXGT009845 Fibrillin-1 2200 reviewed Calcium-binding protein
P36959 BXGT009948 GMP reductase 1 2766 reviewed
P40189 BXGT010164 Interleukin-6 receptor subunit beta 3572 reviewed Signaling
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P41212 BXGT010235 Transcription factor ETV6 2120 reviewed Transcription factor
P41235 BXGT010241 Hepatocyte nuclear factor 4-alpha 3172 reviewed Nuclear receptor
P41440 BXGT010261 Folate transporter 1 6573 reviewed Transporter
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43354 BXGT010381 Nuclear receptor subfamily 4 group A member 2 4929 reviewed Nuclear receptor
P43490 BXGT010395 Nicotinamide phosphoribosyltransferase 10135 reviewed Signaling
P49747 BXGT010732 Cartilage oligomeric matrix protein 1311 reviewed
P49917 BXGT010765 DNA ligase 4 3981 reviewed
P51159 BXGT010839 Ras-related protein Rab-27A 5873 reviewed
P51617 BXGT010868 Interleukin-1 receptor-associated kinase 1 3654 reviewed Kinase
P51679 BXGT010877 C-C chemokine receptor type 4 1233 reviewed G-protein coupled receptor
P51681 BXGT010878 C-C chemokine receptor type 5 1234 reviewed G-protein coupled receptor
P51687 BXGT010882 Sulfite oxidase, mitochondrial 6821 reviewed
P51965 BXGT010911 Ubiquitin-conjugating enzyme E2 E1 7324 reviewed
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P55040 BXGT011099 GTP-binding protein GEM 2669 reviewed
P57059 BXGT011210 Serine/threonine-protein kinase SIK1 150094 reviewed
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60900 BXGT011338 Proteasome subunit alpha type-6 5687 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P61626 BXGT011382 Lysozyme C 4069 reviewed
P78310 BXGT011830 Coxsackievirus and adenovirus receptor 1525 reviewed
P78380 BXGT011841 Oxidized low-density lipoprotein receptor 1 4973 reviewed
P78556 BXGT011849 C-C motif chemokine 20 6364 reviewed Signaling
P80511 BXGT011914 Protein S100-A12 6283 reviewed Calcium-binding protein
P82279 BXGT011972 Protein crumbs homolog 1 23418 reviewed
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 4088 reviewed Transcription factor
P98066 BXGT012225 Tumor necrosis factor-inducible gene 6 protein 7130 reviewed
Q00534 BXGT012533 Cyclin-dependent kinase 6 1021 reviewed Kinase
Q03405 BXGT012713 Urokinase plasminogen activator surface receptor 5329 reviewed
Q03518 BXGT012723 Antigen peptide transporter 1 6890 reviewed Transporter
Q04759 BXGT012781 Protein kinase C theta type 5588 reviewed Kinase
Q12794 BXGT013265 Hyaluronidase-1 3373 reviewed Enzyme
Q12840 BXGT013269 Kinesin heavy chain isoform 5A 3798 reviewed Cellular structure
Q13085 BXGT013309 Acetyl-CoA carboxylase 1 31 reviewed
Q13231 BXGT013329 Chitotriosidase-1 1118 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13574 BXGT013379 Diacylglycerol kinase zeta 8525 reviewed Enzyme
Q13586 BXGT013380 Stromal interaction molecule 1 6786 reviewed
Q13885 BXGT013400 Tubulin beta-2A chain 7280 reviewed Cellular structure
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14118 BXGT013444 Dystroglycan 1605 reviewed Receptor
Q14393 BXGT013466 Growth arrest-specific protein 6 2621 reviewed Extracellular structure
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 9970 reviewed Nuclear receptor
Q15063 BXGT013531 Periostin 10631 reviewed Signaling
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15485 BXGT013574 Ficolin-2 2220 reviewed Signaling
Q15652 BXGT013587 Probable JmjC domain-containing histone demethylation protein 2C 221037 reviewed
Q15833 BXGT013605 Syntaxin-binding protein 2 6813 reviewed Transporter
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q30154 BXGT014296 HLA class II histocompatibility antigen, DR beta 5 chain 3127 reviewed Immune response
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q5S007 BXGT015650 Leucine-rich repeat serine/threonine-protein kinase 2 120892 reviewed Kinase
Q5VWK5 BXGT015891 Interleukin-23 receptor 149233 reviewed Signaling
Q5Y7D3 BXGT015912 HLA class II histocompatibility antigen DQ beta chain 3119 unreviewed
Q676U5 BXGT016177 Autophagy-related protein 16-1 55054 reviewed
Q6P179 BXGT016440 Endoplasmic reticulum aminopeptidase 2 64167 reviewed Enzyme
Q7Z7D3 BXGT017262 V-set domain-containing T-cell activation inhibitor 1 79679 reviewed Enzyme modulator
Q86VW1 BXGT017621 Solute carrier family 22 member 16 85413 reviewed Transporter
Q8WZ42 BXGT019023 Titin 7273 reviewed Kinase
Q96AZ6 BXGT019621 Interferon-stimulated gene 20 kDa protein 3669 reviewed
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q99712 BXGT019953 ATP-sensitive inward rectifier potassium channel 15 3772 reviewed Ion channel
Q9BY08 BXGT020177 Emopamil-binding protein-like 84650 reviewed Enzyme
Q9BY32 BXGT020179 Inosine triphosphate pyrophosphatase 3704 reviewed Enzyme
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9C000 BXGT020206 NACHT, LRR and PYD domains-containing protein 1 22861 reviewed
Q9HC97 BXGT020527 G-protein coupled receptor 35 2859 reviewed G-protein coupled receptor
Q9NP58 BXGT021143 ATP-binding cassette sub-family B member 6, mitochondrial 10058 reviewed Transporter
Q9NP99 BXGT021148 Triggering receptor expressed on myeloid cells 1 54210 reviewed
Q9NYK1 BXGT021258 Toll-like receptor 7 51284 reviewed
Q9NYY3 BXGT021264 Serine/threonine-protein kinase PLK2 10769 reviewed Kinase
Q9NZ08 BXGT021266 Endoplasmic reticulum aminopeptidase 1 51752 reviewed Enzyme
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9P0X4 BXGT021293 Voltage-dependent T-type calcium channel subunit alpha-1I 8911 reviewed Ion channel
Q9UBM7 BXGT021657 7-dehydrocholesterol reductase 1717 reviewed Enzyme
Q9UKE5 BXGT021741 TRAF2 and NCK-interacting protein kinase 23043 reviewed Kinase
Q9UKU7 BXGT021749 Isobutyryl-CoA dehydrogenase, mitochondrial 27034 reviewed Enzyme
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9ULJ6 BXGT021761 Zinc finger MIZ domain-containing protein 1 57178 reviewed
Q9UM07 BXGT021771 Protein-arginine deiminase type-4 23569 reviewed
Q9UNF0 BXGT021786 Protein kinase C and casein kinase substrate in neurons protein 2 11252 reviewed Cellular structure
Q9Y2R2 BXGT022243 Tyrosine-protein phosphatase non-receptor type 22 26191 reviewed
Q9Y5K3 BXGT022294 Choline-phosphate cytidylyltransferase B 9468 reviewed
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
Q5JP69 BXGT022691 C3/C5 convertase 717 unreviewed
P20036 BXGT022764 HLA class II histocompatibility antigen, DP alpha 1 chain 3113 reviewed Immune response
Q14186 BXGT023367 Transcription factor Dp-1 7027 reviewed Nucleic acid binding
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
P53539 BXGT023438 Protein fosB 2354 reviewed Transcription factor
P51608 BXGT025073 Methyl-CpG-binding protein 2 4204 reviewed Epigenetic regulator
Q96SD1 BXGT025929 Protein artemis 64421 reviewed
Q8IVT5 BXGT026146 Kinase suppressor of Ras 1 8844 reviewed Kinase
P07320 BXGT026150 Gamma-crystallin D 1421 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease