Showing entry for Microsomal glutathione S-transferase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007590
Protein NameMicrosomal glutathione S-transferase 1
Uniport IdP10620
GeneMGST1
Gene Id4257
DomainMAPEG
Pfam PF01124  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.6 Metabolism of other amino acids hsa00480 Glutathione metabolism
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00982 Drug metabolism - cytochrome P450
1. Metabolism 1.11 Xenobiotics biodegradation and metabolism hsa00983 Drug metabolism - other enzymes
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
6. Human Diseases 6.12 Drug resistance: Antineoplastic hsa01524 Platinum drug resistance
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.1 Cancers: Overview hsa05204 Chemical carcinogenesis
6. Human Diseases 6.2 Cancers: Specific types hsa05225 Hepatocellular carcinoma
6. Human Diseases 6.6 Cardiovascular diseases hsa05418 Fluid shear stress and atherosclerosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0071449 cellular response to lipid hydroperoxide
Biological Process GO:1901687 glutathione derivative biosynthetic process
Biological Process GO:0033327 Leydig cell differentiation
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:0042493 response to drug
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0010243 response to organonitrogen compound
Biological Process GO:0006805 xenobiotic metabolic process
molecular function GO:0043295 glutathione binding
molecular function GO:0004602 glutathione peroxidase activity
molecular function GO:0004364 glutathione transferase activity
molecular function GO:0042802 identical protein binding
cellular component GO:0045177 apical part of cell
cellular component GO:0035577 azurophil granule membrane
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005741 mitochondrial outer membrane
cellular component GO:0005739 mitochondrion
cellular component GO:0005634 nucleus
cellular component GO:0005778 peroxisomal membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-156580 Phase II - Conjugation of compounds
R-HSA-156590 Glutathione conjugation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-211859 Biological oxidations
R-HSA-5423646 Aflatoxin activation and detoxification
R-HSA-6798695 Neutrophil degranulation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004763 BXGD000289 Barrett Esophagus Digestive System Diseases; Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0017154 BXGD001097 Gastritis, Atrophic Digestive System Diseases
C0018798 BXGD001223 Congenital Heart Defects Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0023055 BXGD001604 Laryngeal neoplasm Neoplasms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0026764 BXGD001928 Multiple Myeloma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0040517 BXGD002872 Gilles de la Tourette syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0206368 BXGD004176 Exfoliation Syndrome Eye Diseases
C0238339 BXGD004914 Hereditary pancreatitis Digestive System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0270715 BXGD006089 Degenerative Diseases, Central Nervous System Nervous System Diseases
C0334037 BXGD006980 Intestinal metaplasia
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0553580 BXGD009399 Ewings sarcoma Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751733 BXGD010569 Degenerative Diseases, Spinal Cord Nervous System Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1853238 BXGD015320 Conotruncal defect
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C3899155 BXGD020075 hereditary neuroblastoma Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4721414 BXGD023738 Mantle cell lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000989 Glutathione 307.32
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein