adisease

Showing entry for Barrett Esophagus

General Disease Information
BXGD Id	BXGD000289
Disease Name	Barrett Esophagus
Disease CUI Id	C0004763
MeSH Codes	C06 C04
Disease Class Name	Digestive System Diseases; Neoplasms
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0025031 HP:0002664
Human Phenotype Ontology Term	Abnormality of the digestive system; Neoplasm
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
A0A024RAV5	BXGT000013	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b	3845	unreviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O14684	BXGT004082	Prostaglandin E synthase	9536	reviewed
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15075	BXGT004124	Serine/threonine-protein kinase DCLK1	9201	reviewed	Kinase
O15440	BXGT004170	Multidrug resistance-associated protein 5	10057	reviewed	Transporter
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O43683	BXGT004614	Mitotic checkpoint serine/threonine-protein kinase BUB1	699	reviewed	Kinase
O60218	BXGT004858	Aldo-keto reductase family 1 member B10	57016	reviewed	Enzyme
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75116	BXGT005100	Rho-associated protein kinase 2	9475	reviewed	Kinase
O75362	BXGT005114	Zinc finger protein 217	7764	reviewed
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O75473	BXGT005129	Leucine-rich repeat-containing G-protein coupled receptor 5	8549	reviewed	G-protein coupled receptor
O94788	BXGT005333	Retinal dehydrogenase 2	8854	reviewed	Enzyme
O94811	BXGT005336	Tubulin polymerization-promoting protein	11076	reviewed	Cellular structure
O94907	BXGT005340	Dickkopf-related protein 1	22943	reviewed
O95256	BXGT005364	Interleukin-18 receptor accessory protein	8807	reviewed	Receptor
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01116	BXGT005733	GTPase KRas	3845	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02533	BXGT005887	Keratin, type I cytoskeletal 14	3861	reviewed
P02748	BXGT005940	Complement component C9	735	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04004	BXGT006125	Vitronectin	7448	reviewed
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04083	BXGT006147	Annexin A1	301	reviewed
P04155	BXGT006155	Trefoil factor 1	7031	reviewed	Signaling
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04792	BXGT006264	Heat shock protein beta-1	3315	reviewed
P04818	BXGT006269	Thymidylate synthase	7298	reviewed	Enzyme
P05093	BXGT006313	Steroid 17-alpha-hydroxylase/17,20 lyase	1586	reviewed
P05230	BXGT006344	Fibroblast growth factor 1	2246	reviewed	Signaling
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06126	BXGT006412	T-cell surface glycoprotein CD1a	909	reviewed
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P07148	BXGT006559	Fatty acid-binding protein, liver	2168	reviewed
P07203	BXGT006566	Glutathione peroxidase 1	2876	reviewed	Enzyme
P07339	BXGT006604	Cathepsin D	1509	reviewed	Enzyme
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08174	BXGT006739	Complement decay-accelerating factor	1604	reviewed
P08246	BXGT006756	Neutrophil elastase	1991	reviewed	Enzyme
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08670	BXGT006810	Vimentin	7431	reviewed
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09237	BXGT006874	Matrilysin	4316	reviewed	Enzyme
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09455	BXGT006890	Retinol-binding protein 1	5947	reviewed
P09486	BXGT006897	SPARC	6678	reviewed	Signaling
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10144	BXGT007541	Granzyme B	3002	reviewed	Enzyme
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10620	BXGT007590	Microsomal glutathione S-transferase 1	4257	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P12830	BXGT007852	Cadherin-1	999	reviewed
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P13647	BXGT007937	Keratin, type II cytoskeletal 5	3852	reviewed
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14410	BXGT008009	Sucrase-isomaltase, intestinal	6476	reviewed	Enzyme
P14616	BXGT008026	Insulin receptor-related protein	3645	reviewed	Kinase
P14625	BXGT008029	Endoplasmin	7184	reviewed	Chaperone
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15144	BXGT008087	Aminopeptidase N	290	reviewed	Enzyme
P15428	BXGT008121	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	3248	reviewed
P15531	BXGT008136	Nucleoside diphosphate kinase A	4830	reviewed	Kinase
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	1728	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15941	BXGT008176	Mucin-1	4582	reviewed
P16070	BXGT008186	CD44 antigen	960	reviewed
P16455	BXGT008229	Methylated-DNA--protein-cysteine methyltransferase	4255	reviewed
P17936	BXGT008357	Insulin-like growth factor-binding protein 3	3486	reviewed	Enzyme modulator
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18283	BXGT008395	Glutathione peroxidase 2	2877	reviewed	Enzyme
P18887	BXGT008437	DNA repair protein XRCC1	7515	reviewed
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P19634	BXGT008504	Sodium/hydrogen exchanger 1	6548	reviewed	Transporter
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P19971	BXGT008537	Thymidine phosphorylase	1890	reviewed	Enzyme
P20248	BXGT008554	Cyclin-A2	890	reviewed	Enzyme modulator
P20711	BXGT008594	Aromatic-L-amino-acid decarboxylase	1644	reviewed
P21453	BXGT008654	Sphingosine 1-phosphate receptor 1	1901	reviewed	G-protein coupled receptor
P21673	BXGT008676	Diamine acetyltransferase 1	6303	reviewed
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P21980	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	7052	reviewed	Enzyme
P22083	BXGT008727	Alpha-(1,3)-fucosyltransferase 4	2526	reviewed	Enzyme
P22352	BXGT008758	Glutathione peroxidase 3	2878	reviewed	Enzyme
P23219	BXGT008837	Prostaglandin G/H synthase 1	5742	reviewed	Enzyme
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24855	BXGT008998	Deoxyribonuclease-1	1773	reviewed
P24941	BXGT009002	Cyclin-dependent kinase 2	1017	reviewed	Kinase
P25116	BXGT009025	Proteinase-activated receptor 1	2149	reviewed	G-protein coupled receptor
P26447	BXGT009114	Protein S100-A4	6275	reviewed	Calcium-binding protein
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28161	BXGT009234	Glutathione S-transferase Mu 2	2946	reviewed
P28908	BXGT009302	Tumor necrosis factor receptor superfamily member 8	943	reviewed
P29372	BXGT009336	DNA-3-methyladenine glycosylase	4350	reviewed	Enzyme
P29460	BXGT009348	Interleukin-12 subunit beta	3593	reviewed	Signaling
P30559	BXGT009442	Oxytocin receptor	5021	reviewed	G-protein coupled receptor
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P31151	BXGT009510	Protein S100-A7	6278	reviewed	Calcium-binding protein
P32239	BXGT009612	Gastrin/cholecystokinin type B receptor	887	reviewed	G-protein coupled receptor
P33681	BXGT009739	T-lymphocyte activation antigen CD80	941	reviewed
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35610	BXGT009855	Sterol O-acyltransferase 1	6646	reviewed	Enzyme
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P40199	BXGT010166	Carcinoembryonic antigen-related cell adhesion molecule 6	4680	reviewed
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P43116	BXGT010357	Prostaglandin E2 receptor EP2 subtype	5732	reviewed	G-protein coupled receptor
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P45452	BXGT010462	Collagenase 3	4322	reviewed	Enzyme
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P49327	BXGT010694	Fatty acid synthase	2194	reviewed	Enzyme
P49789	BXGT010742	Bis(5'-adenosyl)-triphosphatase	2272	reviewed
P50750	BXGT010818	Cyclin-dependent kinase 9	1025	reviewed	Kinase
P51161	BXGT010841	Gastrotropin	2172	reviewed
P52701	BXGT010943	DNA mismatch repair protein Msh6	2956	reviewed	Nucleic acid binding
P52895	BXGT010961	Aldo-keto reductase family 1 member C2	1646	reviewed	Enzyme
P53355	BXGT010985	Death-associated protein kinase 1	1612	reviewed	Kinase
P54278	BXGT011038	Mismatch repair endonuclease PMS2	5395	reviewed	Nucleic acid binding
P54707	BXGT011068	Potassium-transporting ATPase alpha chain 2	479	reviewed	Transporter
P54760	BXGT011075	Ephrin type-B receptor 4	2050	reviewed	Kinase
P55318	BXGT011119	Hepatocyte nuclear factor 3-gamma	3171	reviewed	Transcription factor
P56945	BXGT011206	Breast cancer anti-estrogen resistance protein 1	9564	reviewed
P60022	BXGT011285	Beta-defensin 1	1672	reviewed
P60568	BXGT011315	Interleukin-2	3558	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P78417	BXGT011843	Glutathione S-transferase omega-1	9446	reviewed
P78504	BXGT011844	Protein jagged-1	182	reviewed
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q03403	BXGT012712	Trefoil factor 2	7032	reviewed	Signaling
Q04206	BXGT012754	Transcription factor p65	5970	reviewed	Transcription factor
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q07820	BXGT012942	Induced myeloid leukemia cell differentiation protein Mcl-1	4170	reviewed	Signaling
Q08257	BXGT012975	Quinone oxidoreductase	1429	reviewed
Q12809	BXGT013267	Potassium voltage-gated channel subfamily H member 2	3757	reviewed	Ion channel
Q12908	BXGT013278	Ileal sodium/bile acid cotransporter	6555	reviewed	Transporter
Q13126	BXGT013313	S-methyl-5'-thioadenosine phosphorylase	4507	reviewed	Enzyme
Q13144	BXGT013317	Translation initiation factor eIF-2B subunit epsilon	8893	reviewed
Q13257	BXGT013333	Mitotic spindle assembly checkpoint protein MAD2A	4085	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13477	BXGT013361	Mucosal addressin cell adhesion molecule 1	8174	reviewed
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13887	BXGT013401	Krueppel-like factor 5	688	reviewed	Nucleic acid binding
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q14145	BXGT013448	Kelch-like ECH-associated protein 1	9817	reviewed
Q14451	BXGT013471	Growth factor receptor-bound protein 7	2886	reviewed	Receptor
Q14457	BXGT013472	Beclin-1	8678	reviewed	Enzyme modulator
Q15652	BXGT013587	Probable JmjC domain-containing histone demethylation protein 2C	221037	reviewed
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q16878	BXGT013687	Cysteine dioxygenase type 1	1036	reviewed
Q29980	BXGT013981	MHC class I polypeptide-related sequence B	4277	reviewed
Q30201	BXGT014297	Hereditary hemochromatosis protein	3077	reviewed
Q53EL6	BXGT015008	Programmed cell death protein 4	27250	reviewed	Nucleic acid binding
Q5VWK5	BXGT015891	Interleukin-23 receptor	149233	reviewed	Signaling
Q6ZQY3	BXGT016636	Acidic amino acid decarboxylase GADL1	339896	reviewed
Q7KZI7	BXGT016990	Serine/threonine-protein kinase MARK2	2011	reviewed	Kinase
Q86V24	BXGT017615	Adiponectin receptor protein 2	79602	reviewed	Receptor
Q8TDU6	BXGT018814	G-protein coupled bile acid receptor 1	151306	reviewed	G-protein coupled receptor
Q8WWA0	BXGT018999	Intelectin-1	55600	reviewed
Q8WXA8	BXGT019008	5-hydroxytryptamine receptor 3C	170572	reviewed	Ion channel
Q96A70	BXGT019615	Antizyme inhibitor 2	113451	reviewed	Enzyme
Q96RI1	BXGT019727	Bile acid receptor	9971	reviewed	Nuclear receptor
Q96SL4	BXGT019741	Glutathione peroxidase 7	2882	reviewed	Enzyme
Q99593	BXGT019939	T-box transcription factor TBX5	6910	reviewed	Transcription factor
Q99707	BXGT019952	Methionine synthase	4548	reviewed
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9UM47	BXGT021772	Neurogenic locus notch homolog protein 3	4854	reviewed
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q9Y2Q3	BXGT022242	Glutathione S-transferase kappa 1	373156	reviewed
Q9Y5W5	BXGT022303	Wnt inhibitory factor 1	11197	reviewed	Calcium-binding protein
P43146	BXGT022852	Netrin receptor DCC	1630	reviewed
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
P00395	BXGT023596	Cytochrome c oxidase subunit 1	4512	reviewed	Enzyme
Q96QC4	BXGT023878	MHC class I polypeptide-related sequence A	100507436	unreviewed
P07954	BXGT023939	Fumarate hydratase, mitochondrial	2271	reviewed	Enzyme
O60232	BXGT024169	Protein ZNRD2	10534	reviewed
P16104	BXGT024571	Histone H2AX	3014	reviewed	Nucleic acid binding
Q96A54	BXGT024681	Adiponectin receptor protein 1	51094	reviewed	Receptor
Q92832	BXGT025242	Protein kinase C-binding protein NELL1	4745	reviewed	Calcium-binding protein
P19474	BXGT025520	E3 ubiquitin-protein ligase TRIM21	6737	reviewed
Q7Z628	BXGT026116	Neuroepithelial cell-transforming gene 1 protein	10276	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}