Showing entry for Guanine nucleotide-binding protein G(t) subunit alpha-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007713
Protein NameGuanine nucleotide-binding protein G(t) subunit alpha-1
Uniport IdP11488
GeneGNAT1
Gene Id2779
DomainG-alpha
Pfam PF00503  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.7 Sensory system hsa04744 Phototransduction
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0008283 cell population proliferation
Biological Process GO:0071257 cellular response to electrical stimulus
Biological Process GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
Biological Process GO:0050908 detection of light stimulus involved in visual perception
Biological Process GO:0042462 eye photoreceptor cell development
Biological Process GO:0001973 G protein-coupled adenosine receptor signaling pathway
Biological Process GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity
Biological Process GO:0007603 phototransduction, visible light
Biological Process GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
Biological Process GO:0006457 protein folding
Biological Process GO:0022400 regulation of rhodopsin mediated signaling pathway
Biological Process GO:0009642 response to light intensity
Biological Process GO:0009416 response to light stimulus
Biological Process GO:0060041 retina development in camera-type eye
Biological Process GO:0016056 rhodopsin mediated signaling pathway
Biological Process GO:0050917 sensory perception of umami taste
Biological Process GO:0007165 signal transduction
Biological Process GO:0007601 visual perception
molecular function GO:0000035 acyl binding
molecular function GO:0019003 GDP binding
molecular function GO:0031683 G-protein beta/gamma-subunit complex binding
molecular function GO:0001664 G protein-coupled receptor binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0046872 metal ion binding
molecular function GO:0019901 protein kinase binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005829 cytosol
cellular component GO:0005834 heterotrimeric G-protein complex
cellular component GO:0016020 membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0032391 photoreceptor connecting cilium
cellular component GO:0097381 photoreceptor disc membrane
cellular component GO:0001917 photoreceptor inner segment
cellular component GO:0001750 photoreceptor outer segment
cellular component GO:0042622 photoreceptor outer segment membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-111885 Opioid Signalling
R-HSA-111885 Opioid Signalling
R-HSA-112040 G-protein mediated events
R-HSA-112040 G-protein mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-112043 PLC beta mediated events
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-202040 G-protein activation
R-HSA-2187338 Visual phototransduction
R-HSA-2187338 Visual phototransduction
R-HSA-2485179 Activation of the phototransduction cascade
R-HSA-2485179 Activation of the phototransduction cascade
R-HSA-2514856 The phototransduction cascade
R-HSA-2514856 The phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-372790 Signaling by GPCR
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-391251 Protein folding
R-HSA-392499 Metabolism of proteins
R-HSA-418594 G alpha (i) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028077 BXGD002069 Nyctalopia Eye Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0271183 BXGD006169 Severe myopia Eye Diseases
C0339535 BXGD007263 Night blindness, congenital stationary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0554970 BXGD009428 Pallor of optic disc
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1298695 BXGD012251 Hypoplasia of optic disc Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Nervous System Diseases
C1848172 BXGD014908 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1850362 BXGD015134 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1854065 BXGD015379 LATE-ONSET RETINAL DEGENERATION (disorder) Eye Diseases
C1864870 BXGD016264 Night Blindness, Congenital Stationary, Autosomal Dominant 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1864877 BXGD016267 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 2B (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C3495587 BXGD018996 Night Blindness, Congenital Stationary, Type 1A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3501847 BXGD019030 Night blindness, congenital stationary, type 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3551052 BXGD019144 Night blindness, stationary
C3669212 BXGD019325 Progressive retinal atrophy
C3711543 BXGD019396 X-Linked Csnb Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4024756 BXGD021405 Abnormality of macular pigmentation
C4041558 BXGD021877 Cone-rod synaptic disorder, congenital nonprogressive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4225345 BXGD022231 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1G
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002248 Dodecanoic acid 200.32
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein