adisease

Showing entry for Disorder of eye

General Disease Information
BXGD Id	BXGD000983
Disease Name	Disorder of eye
Disease CUI Id	C0015397
MeSH Codes	C11
Disease Class Name	Eye Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000478
Human Phenotype Ontology Term	Abnormality of the eye
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00767	BXGT003949	Acyl-CoA desaturase	6319	reviewed
O14773	BXGT004096	Tripeptidyl-peptidase 1	1200	reviewed	Enzyme
O14786	BXGT004099	Neuropilin-1	8829	reviewed
O14832	BXGT004104	Phytanoyl-CoA dioxygenase, peroxisomal	5264	reviewed
O15119	BXGT004128	T-box transcription factor TBX3	6926	reviewed	Transcription factor
O15303	BXGT004150	Metabotropic glutamate receptor 6	2916	reviewed	G-protein coupled receptor
O60313	BXGT004871	Dynamin-like 120 kDa protein, mitochondrial	4976	reviewed	Enzyme modulator
O60840	BXGT004901	Voltage-dependent L-type calcium channel subunit alpha-1F	778	reviewed	Ion channel
O75643	BXGT005142	U5 small nuclear ribonucleoprotein 200 kDa helicase	23020	reviewed
O95237	BXGT005361	Lecithin retinol acyltransferase	9227	reviewed
P00338	BXGT005504	L-lactate dehydrogenase A chain	3939	reviewed	Enzyme
P00505	BXGT005560	Aspartate aminotransferase, mitochondrial	2806	reviewed
P00519	BXGT005570	Tyrosine-protein kinase ABL1	25	reviewed	Kinase
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01236	BXGT005744	Prolactin	5617	reviewed	Signaling
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01903	BXGT005814	HLA class II histocompatibility antigen, DR alpha chain	3122	reviewed	Immune response
P01909	BXGT005815	HLA class II histocompatibility antigen, DQ alpha 1 chain	3117	reviewed	Immune response
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P01920	BXGT005817	HLA class II histocompatibility antigen, DQ beta 1 chain	3119	reviewed	Immune response
P02458	BXGT005879	Collagen alpha-1(II) chain	1280	reviewed
P02462	BXGT005881	Collagen alpha-1(IV) chain	1282	reviewed
P02753	BXGT005945	Retinol-binding protein 4	5950	reviewed	Transporter
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02787	BXGT005962	Serotransferrin	7018	reviewed	Enzyme
P04181	BXGT006165	Ornithine aminotransferase, mitochondrial	4942	reviewed	Enzyme
P04278	BXGT006182	Sex hormone-binding globulin	6462	reviewed
P04440	BXGT006216	HLA class II histocompatibility antigen, DP beta 1 chain	3115	reviewed	Immune response
P05107	BXGT006316	Integrin beta-2	3689	reviewed	Receptor
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P05556	BXGT006368	Integrin beta-1	3688	reviewed	Receptor
P06733	BXGT006490	Alpha-enolase	2023	reviewed	Enzyme
P07339	BXGT006604	Cathepsin D	1509	reviewed	Enzyme
P07550	BXGT006636	Beta-2 adrenergic receptor	154	reviewed	G-protein coupled receptor
P07814	BXGT006680	Bifunctional glutamate/proline--tRNA ligase	2058	reviewed	Enzyme
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08100	BXGT006725	Rhodopsin	6010	reviewed	G-protein coupled receptor
P08603	BXGT006798	Complement factor H	3075	reviewed
P09104	BXGT006856	Gamma-enolase	2026	reviewed	Enzyme
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10745	BXGT007608	Retinol-binding protein 3	5949	reviewed
P11215	BXGT007672	Integrin alpha-M	3684	reviewed
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11488	BXGT007713	Guanine nucleotide-binding protein G(t) subunit alpha-1	2779	reviewed	Enzyme modulator
P11712	BXGT007738	Cytochrome P450 2C9	1559	reviewed
P12081	BXGT007772	Histidine--tRNA ligase, cytoplasmic	3035	reviewed	Enzyme
P12271	BXGT007786	Retinaldehyde-binding protein 1	6017	reviewed	Transporter
P13569	BXGT007923	Cystic fibrosis transmembrane conductance regulator	1080	reviewed	Ion channel
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P14679	BXGT008039	Tyrosinase	7299	reviewed	Enzyme
P15121	BXGT008083	Aldo-keto reductase family 1 member B1	231	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16410	BXGT008224	Cytotoxic T-lymphocyte protein 4	1493	reviewed
P16473	BXGT008234	Thyrotropin receptor	7253	reviewed	G-protein coupled receptor
P16499	BXGT008238	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	5145	reviewed
P17643	BXGT008323	5,6-dihydroxyindole-2-carboxylic acid oxidase	7306	reviewed	Enzyme
P17707	BXGT008331	S-adenosylmethionine decarboxylase proenzyme	262	reviewed	Enzyme
P18850	BXGT008433	Cyclic AMP-dependent transcription factor ATF-6 alpha	22926	reviewed
P19544	BXGT008494	Wilms tumor protein	7490	reviewed	Nucleic acid binding
P19838	BXGT008526	Nuclear factor NF-kappa-B p105 subunit	4790	reviewed	Transcription factor
P20701	BXGT008591	Integrin alpha-L	3683	reviewed
P20794	BXGT008600	Serine/threonine-protein kinase MAK	4117	reviewed	Kinase
P20839	BXGT008608	Inosine-5'-monophosphate dehydrogenase 1	3614	reviewed	Enzyme
P21266	BXGT008632	Glutathione S-transferase Mu 3	2947	reviewed
P22223	BXGT008744	Cadherin-3	1001	reviewed
P22748	BXGT008802	Carbonic anhydrase 4	762	reviewed
P24855	BXGT008998	Deoxyribonuclease-1	1773	reviewed
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28300	BXGT009243	Protein-lysine 6-oxidase	4015	reviewed
P28347	BXGT009257	Transcriptional enhancer factor TEF-1	7003	reviewed	Transcription factor
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29460	BXGT009348	Interleukin-12 subunit beta	3593	reviewed	Signaling
P29973	BXGT009389	cGMP-gated cation channel alpha-1	1259	reviewed	Ion channel
P30711	BXGT009460	Glutathione S-transferase theta-1	2952	reviewed
P33261	BXGT009707	Cytochrome P450 2C19	1557	reviewed
P33681	BXGT009739	T-lymphocyte activation antigen CD80	941	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35408	BXGT009828	Prostaglandin E2 receptor EP4 subtype	5734	reviewed	G-protein coupled receptor
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P35913	BXGT009879	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	5158	reviewed
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P36955	BXGT009946	Pigment epithelium-derived factor	5176	reviewed	Enzyme modulator
P40337	BXGT010174	von Hippel-Lindau disease tumor suppressor	7428	reviewed	Enzyme
P41279	BXGT010254	Mitogen-activated protein kinase kinase kinase 8	1326	reviewed	Kinase
P43080	BXGT010354	Guanylyl cyclase-activating protein 1	2978	reviewed
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P46937	BXGT010554	Transcriptional coactivator YAP1	10413	reviewed	Enzyme modulator
P49888	BXGT010756	Estrogen sulfotransferase	6783	reviewed
P50897	BXGT010823	Palmitoyl-protein thioesterase 1	5538	reviewed	Enzyme
P51160	BXGT010840	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	5146	reviewed
P55157	BXGT011108	Microsomal triglyceride transfer protein large subunit	4547	reviewed	Transporter
P78352	BXGT011836	Disks large homolog 4	1742	reviewed	Receptor
P82279	BXGT011972	Protein crumbs homolog 1	23418	reviewed
Q00536	BXGT012535	Cyclin-dependent kinase 16	5127	reviewed	Kinase
Q00604	BXGT012538	Norrin	4693	reviewed
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q12778	BXGT013263	Forkhead box protein O1	2308	reviewed
Q12866	BXGT013273	Tyrosine-protein kinase Mer	10461	reviewed	Kinase
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13402	BXGT013348	Unconventional myosin-VIIa	4647	reviewed	Cellular structure
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q14116	BXGT013442	Interleukin-18	3606	reviewed
Q15063	BXGT013531	Periostin	10631	reviewed	Signaling
Q15116	BXGT013539	Programmed cell death protein 1	5133	reviewed
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16478	BXGT013630	Glutamate receptor ionotropic, kainate 5	2901	reviewed	Ion channel
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16678	BXGT013656	Cytochrome P450 1B1	1545	reviewed	Enzyme
Q2M1P5	BXGT014129	Kinesin-like protein KIF7	374654	reviewed
Q495M9	BXGT014765	Usher syndrome type-1G protein	124590	reviewed
Q5Y7D3	BXGT015912	HLA class II histocompatibility antigen DQ beta chain	3119	unreviewed
Q6P2Q9	BXGT016446	Pre-mRNA-processing-splicing factor 8	10594	reviewed	Nucleic acid binding
Q7Z494	BXGT017254	Nephrocystin-3	27031	reviewed
Q8TCT9	BXGT018801	Minor histocompatibility antigen H13	81502	reviewed	Enzyme
Q8TDQ0	BXGT018810	Hepatitis A virus cellular receptor 2	84868	reviewed
Q8WWY3	BXGT019006	U4/U6 small nuclear ribonucleoprotein Prp31	26121	reviewed	Nucleic acid binding
Q92781	BXGT019372	Retinol dehydrogenase 5	5959	reviewed	Enzyme
Q92834	BXGT019381	X-linked retinitis pigmentosa GTPase regulator	6103	reviewed
Q92956	BXGT019399	Tumor necrosis factor receptor superfamily member 14	8764	reviewed
Q96AT9	BXGT019619	Ribulose-phosphate 3-epimerase	6120	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96NR8	BXGT019701	Retinol dehydrogenase 12	145226	reviewed	Enzyme
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96QU1	BXGT019721	Protocadherin-15	65217	reviewed
Q96SB4	BXGT019740	SRSF protein kinase 1	6732	reviewed	Kinase
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99784	BXGT019961	Noelin	10439	reviewed	Cellular structure
Q99972	BXGT019979	Myocilin	4653	reviewed	Cellular structure
Q9BXC0	BXGT020165	Hydroxycarboxylic acid receptor 1	27198	reviewed	G-protein coupled receptor
Q9BXJ0	BXGT020169	Complement C1q tumor necrosis factor-related protein 5	114902	reviewed
Q9BZP6	BXGT020201	Acidic mammalian chitinase	27159	reviewed
Q9H0F7	BXGT020435	ADP-ribosylation factor-like protein 6	84100	reviewed
Q9H251	BXGT020449	Cadherin-23	64072	reviewed
Q9H8P0	BXGT020497	Polyprenol reductase	79644	reviewed
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9NR97	BXGT021182	Toll-like receptor 8	51311	reviewed
Q9NTG7	BXGT021211	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	23410	reviewed	Epigenetic regulator
Q9NZN9	BXGT021280	Aryl-hydrocarbon-interacting protein-like 1	23746	reviewed	Chaperone
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9ULV1	BXGT021764	Frizzled-4	8322	reviewed	G-protein coupled receptor
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q9Y5W5	BXGT022303	Wnt inhibitory factor 1	11197	reviewed	Calcium-binding protein
Q9Y5X4	BXGT022306	Photoreceptor-specific nuclear receptor	10002	reviewed	Nuclear receptor
Q9Y6N9	BXGT022337	Harmonin	10083	reviewed	Cellular structure
P04439	BXGT022649	HLA class I histocompatibility antigen, A-3 alpha chain	3105	reviewed
Q7Z3S7	BXGT022658	Voltage-dependent calcium channel subunit alpha-2/delta-4	93589	reviewed	Ion channel
P49619	BXGT022669	Diacylglycerol kinase gamma	1608	reviewed	Enzyme
Q96KN7	BXGT022801	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1	57096	reviewed	Enzyme modulator
P51784	BXGT023311	Ubiquitin carboxyl-terminal hydrolase 11	8237	reviewed	Enzyme
Q6P4Q7	BXGT024061	Metal transporter CNNM4	26504	reviewed
Q13432	BXGT024144	Protein unc-119 homolog A	9094	reviewed	Receptor
O95140	BXGT024482	Mitofusin-2	9927	reviewed	Enzyme
O43837	BXGT024635	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	3420	reviewed	Enzyme
O14958	BXGT025138	Calsequestrin-2	845	reviewed
Q9GZV5	BXGT025439	WW domain-containing transcription regulator protein 1	25937	reviewed	Enzyme modulator
Q9BY76	BXGT025687	Angiopoietin-related protein 4	51129	reviewed	Signaling
Q86SQ9	BXGT025875	Dehydrodolichyl diphosphate synthase complex subunit DHDDS	79947	reviewed	Enzyme
Q05209	BXGT026141	Tyrosine-protein phosphatase non-receptor type 12	5782	reviewed
V9HWB9	BXGT026149	L-lactate dehydrogenase	3939	unreviewed
P02489	BXGT026168	Alpha-crystallin A chain	1409	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}