Showing entry for Nucleoprotein TPR



                       
General Target Information
BXGT IdBXGT007785
Protein NameNucleoprotein TPR
Uniport IdP12270
GeneTPR
Gene Id7175
DomainTPR_MLP1_2
Pfam PF07926  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa03013 RNA transport
6. Human Diseases 6.1 Cancers: Overview hsa05200 Pathways in cancer
6. Human Diseases 6.2 Cancers: Specific types hsa05216 Thyroid cancer
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0051301 cell division
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0035457 cellular response to interferon-alpha
Biological Process GO:0075733 intracellular transport of virus
Biological Process GO:0007094 mitotic spindle assembly checkpoint
Biological Process GO:0006406 mRNA export from nucleus
Biological Process GO:0031990 mRNA export from nucleus in response to heat stress
Biological Process GO:0046832 negative regulation of RNA export from nucleus
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0045947 negative regulation of translational initiation
Biological Process GO:0006999 nuclear pore organization
Biological Process GO:0031453 positive regulation of heterochromatin assembly
Biological Process GO:0090316 positive regulation of intracellular protein transport
Biological Process GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
Biological Process GO:0046827 positive regulation of protein export from nucleus
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0016925 protein sumoylation
Biological Process GO:1900034 regulation of cellular response to heat
Biological Process GO:0060964 regulation of gene silencing by miRNA
Biological Process GO:0006110 regulation of glycolytic process
Biological Process GO:0010965 regulation of mitotic sister chromatid separation
Biological Process GO:1901673 regulation of mitotic spindle assembly
Biological Process GO:0032880 regulation of protein localization
Biological Process GO:0070849 response to epidermal growth factor
Biological Process GO:0006405 RNA export from nucleus
Biological Process GO:0006404 RNA import into nucleus
Biological Process GO:0006409 tRNA export from nucleus
Biological Process GO:0016032 viral process
Biological Process GO:0019083 viral transcription
molecular function GO:0003682 chromatin binding
molecular function GO:0070840 dynein complex binding
molecular function GO:0031072 heat shock protein binding
molecular function GO:0051019 mitogen-activated protein kinase binding
molecular function GO:0003729 mRNA binding
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0003723 RNA binding
molecular function GO:0017056 structural constituent of nuclear pore
molecular function GO:0015631 tubulin binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005868 cytoplasmic dynein complex
cellular component GO:0019898 extrinsic component of membrane
cellular component GO:0043657 host cell
cellular component GO:0000776 kinetochore
cellular component GO:0072686 mitotic spindle
cellular component GO:0005635 nuclear envelope
cellular component GO:0042405 nuclear inclusion body
cellular component GO:0031965 nuclear membrane
cellular component GO:0034399 nuclear periphery
cellular component GO:0005643 nuclear pore
cellular component GO:0044615 nuclear pore nuclear basket
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1430728 Metabolism
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-162587 HIV Life Cycle
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-162906 HIV Infection
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-1643685 Disease
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-168255 Influenza Infection
R-HSA-168256 Immune System
R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-176033 Interactions of Vpr with host cellular proteins
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-180746 Nuclear import of Rev protein
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-191859 snRNP Assembly
R-HSA-194441 Metabolism of non-coding RNA
R-HSA-211000 Gene Silencing by RNA
R-HSA-2262752 Cellular responses to stress
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-2990846 SUMOylation
R-HSA-2990846 SUMOylation
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-3232142 SUMOylation of ubiquitinylation proteins
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371556 Cellular response to heat stress
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-4085377 SUMOylation of SUMOylation proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-5619102 SLC transporter disorders
R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
R-HSA-5619115 Disorders of transmembrane transporters
R-HSA-5663205 Infectious disease
R-HSA-5663205 Infectious disease
R-HSA-597592 Post-translational protein modification
R-HSA-597592 Post-translational protein modification
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-68875 Mitotic Prophase
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-70171 Glycolysis
R-HSA-70326 Glucose metabolism
R-HSA-71387 Metabolism of carbohydrates
R-HSA-72202 Transport of Mature Transcript to Cytoplasm
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-72306 tRNA processing
R-HSA-74160 Gene expression (Transcription)
R-HSA-8953854 Metabolism of RNA
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-913531 Interferon Signaling
R-HSA-9609646 HCMV Infection
R-HSA-9609690 HCMV Early Events
R-HSA-9610379 HCMV Late Events
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0014474 BXGD000917 Ependymoma Neoplasms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0033300 BXGD002403 Progeria Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0038356 BXGD002747 Stomach Neoplasms Digestive System Diseases; Neoplasms
C0038443 BXGD002757 Stress, Psychological Behavior and Behavior Mechanisms
C0039128 BXGD002794 Syphilis Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0151468 BXGD003424 Thyroid Gland Follicular Adenoma Neoplasms; Endocrine System Diseases
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0265264 BXGD005490 Holt-Oram syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Cardiovascular Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0431376 BXGD008678 Cobblestone Lissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C1292758 BXGD012229 Precursor T-cell lymphoblastic lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332213 BXGD012507 Adult T Lymphoblastic Lymphoma
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1332998 BXGD012577 Childhood T Lymphoblastic Lymphoma
C1611743 BXGD013456 Familial (FPAH)
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1859690 BXGD015919 CAMPTODACTYLY-ARTHROPATHY-COXA VARA-PERICARDITIS SYNDROME Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C2827362 BXGD017794 Myeloid/Lymphoid Neoplasms with FGFR1 Rearrangement
C3274592 BXGD018655 Lipofibromatosis Neoplasms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4025886 BXGD021846 Severe periodontitis Stomatognathic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0038991 Selenomethionine 197
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein