adisease

Showing entry for Progeria

General Disease Information
BXGD Id	BXGD002403
Disease Name	Progeria
Disease CUI Id	C0033300
MeSH Codes	C16 C18
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id	DOID:630
Disease Ontology Class Name	genetic disease
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O14980	BXGT004119	Exportin-1	7514	reviewed	Receptor
O43464	BXGT004595	Serine protease HTRA2, mitochondrial	27429	reviewed
O43854	BXGT004630	EGF-like repeat and discoidin I-like domain-containing protein 3	10085	reviewed	Enzyme
O60566	BXGT004884	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	701	reviewed	Kinase
O75223	BXGT005106	Gamma-glutamylcyclotransferase	79017	reviewed
O75844	BXGT005156	CAAX prenyl protease 1 homolog	10269	reviewed	Enzyme
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P01023	BXGT005718	Alpha-2-macroglobulin	2	reviewed	Enzyme modulator
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02818	BXGT005969	Osteocalcin	632	reviewed
P04054	BXGT006136	Phospholipase A2	5319	reviewed	Enzyme
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05186	BXGT006338	Alkaline phosphatase, tissue-nonspecific isozyme	249	reviewed	Enzyme
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P08174	BXGT006739	Complement decay-accelerating factor	1604	reviewed
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P10826	BXGT007622	Retinoic acid receptor beta	5915	reviewed	Nuclear receptor
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P12270	BXGT007785	Nucleoprotein TPR	7175	reviewed
P14324	BXGT008005	Farnesyl pyrophosphate synthase	2224	reviewed	Enzyme
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	1728	reviewed
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P19440	BXGT008481	Glutathione hydrolase 1 proenzyme	2678	reviewed	Enzyme
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P31947	BXGT009589	14-3-3 protein sigma	2810	reviewed	Chaperone
P32322	BXGT009624	Pyrroline-5-carboxylate reductase 1, mitochondrial	5831	reviewed
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P36956	BXGT009947	Sterol regulatory element-binding protein 1	6720	reviewed
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P54646	BXGT011062	5'-AMP-activated protein kinase catalytic subunit alpha-2	5563	reviewed	Kinase
P54886	BXGT011092	Delta-1-pyrroline-5-carboxylate synthase	5832	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P60891	BXGT011337	Ribose-phosphate pyrophosphokinase 1	5631	reviewed	Kinase
P62826	BXGT011463	GTP-binding nuclear protein Ran	5901	reviewed	Enzyme modulator
P63104	BXGT011499	14-3-3 protein zeta/delta	7534	reviewed	Chaperone
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q03468	BXGT012716	DNA excision repair protein ERCC-6	2074	reviewed
Q06609	BXGT012884	DNA repair protein RAD51 homolog 1	5888	reviewed
Q07955	BXGT012951	Serine/arginine-rich splicing factor 1	6426	reviewed	Nucleic acid binding
Q08050	BXGT012958	Forkhead box protein M1	2305	reviewed
Q12791	BXGT013264	Calcium-activated potassium channel subunit alpha-1	3778	reviewed	Ion channel
Q13131	BXGT013314	5'-AMP-activated protein kinase catalytic subunit alpha-1	5562	reviewed	Kinase
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13501	BXGT013365	Sequestosome-1	8878	reviewed
Q14191	BXGT013452	Werner syndrome ATP-dependent helicase	7486	reviewed	Enzyme
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q8N6T7	BXGT018525	NAD-dependent protein deacetylase sirtuin-6	51548	reviewed	Epigenetic regulator
Q92769	BXGT019370	Histone deacetylase 2	3066	reviewed	Epigenetic regulator
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q9BQP7	BXGT020114	Mitochondrial genome maintenance exonuclease 1	92667	reviewed
Q9BYW2	BXGT020192	Histone-lysine N-methyltransferase SETD2	29072	reviewed	Epigenetic regulator
Q9H0A0	BXGT020434	RNA cytidine acetyltransferase	55226	reviewed
Q9H9B1	BXGT020501	Histone-lysine N-methyltransferase EHMT1	79813	reviewed	Epigenetic regulator
Q9Y478	BXGT022271	5'-AMP-activated protein kinase subunit beta-1	5564	reviewed	Kinase
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion
Q59FF6	BXGT023693	Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant	2074	unreviewed
Q9HAU4	BXGT024040	E3 ubiquitin-protein ligase SMURF2	64750	reviewed	Enzyme
P16104	BXGT024571	Histone H2AX	3014	reviewed	Nucleic acid binding
Q9H040	BXGT024831	SprT-like domain-containing protein Spartan	83932	reviewed
Q12888	BXGT024878	TP53-binding protein 1	7158	reviewed	Epigenetic regulator
Q96MS0	BXGT025241	Roundabout homolog 3	64221	reviewed	Receptor
O94901	BXGT025393	SUN domain-containing protein 1	23353	reviewed	Cellular structure

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}