Showing entry for Xanthine dehydrogenase/oxidase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008824
Protein NameXanthine dehydrogenase/oxidase
Uniport IdP22985
GeneXdh
Gene Id497811
DomainAld_Xan_dh_C; Ald_Xan_dh_C2; CO_deh_flav_C; FAD_binding_5; Fer2; Fer2_2
Pfam PF01315   PF02738   PF03450   PF00941   PF00111   PF01799  
OrganismRattus norvegicus (Rat)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0007568 aging
Biological Process GO:0071347 cellular response to interleukin-1
Biological Process GO:0071356 cellular response to tumor necrosis factor
Biological Process GO:0006150 hypoxanthine oxidation
Biological Process GO:0007595 lactation
Biological Process GO:0045602 negative regulation of endothelial cell differentiation
Biological Process GO:0001937 negative regulation of endothelial cell proliferation
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0051898 negative regulation of protein kinase B signaling
Biological Process GO:0001933 negative regulation of protein phosphorylation
Biological Process GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
Biological Process GO:2001213 negative regulation of vasculogenesis
Biological Process GO:0055114 oxidation-reduction process
Biological Process GO:1900745 positive regulation of p38MAPK cascade
Biological Process GO:2000379 positive regulation of reactive oxygen species metabolic process
Biological Process GO:0030856 regulation of epithelial cell differentiation
Biological Process GO:0010044 response to aluminum ion
Biological Process GO:0097184 response to azide
Biological Process GO:0034465 response to carbon monoxide
Biological Process GO:0009408 response to heat
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0032496 response to lipopolysaccharide
Biological Process GO:0009115 xanthine catabolic process
molecular function GO:0051537 2 iron, 2 sulfur cluster binding
molecular function GO:0009055 electron transfer activity
molecular function GO:0071949 FAD binding
molecular function GO:0050660 flavin adenine dinucleotide binding
molecular function GO:0042802 identical protein binding
molecular function GO:0005506 iron ion binding
molecular function GO:0043546 molybdopterin cofactor binding
molecular function GO:0050421 nitrite reductase (NO-forming) activity
molecular function GO:0016491 oxidoreductase activity
molecular function GO:0042803 protein homodimerization activity
molecular function GO:0004854 xanthine dehydrogenase activity
molecular function GO:0004855 xanthine oxidase activity
cellular component GO:0005829 cytosol
cellular component GO:0005615 extracellular space
cellular component GO:0005777 peroxisome
cellular component GO:0016529 sarcoplasmic reticulum
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000528 Salicylic acid 138.12
BXGC0000764 L-Ascorbic acid 176.12
BXGC0001789 Silibinin 482.44
BXGC0002586 Calcium 40.08
BXGC0004277 Acetic acid 60.05
BXGC0008062 Uric acid 168.11
BXGC0011323 2,3-Dehydrosilybin 480.42
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein