Showing entry for Megakaryocyte-associated tyrosine-protein kinase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010328
Protein NameMegakaryocyte-associated tyrosine-protein kinase
Uniport IdP42679
GeneMATK
Gene Id4145
DomainPkinase_Tyr; SH2; SH3_1
Pfam PF07714   PF00017   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.6 Nervous system hsa04722 Neurotrophin signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0038128 ERBB2 signaling pathway
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0006468 protein phosphorylation
molecular function GO:0005524 ATP binding
molecular function GO:0004715 non-membrane spanning protein tyrosine kinase activity
molecular function GO:0004713 protein tyrosine kinase activity
cellular component GO:0005829 cytosol
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-1227986 Signaling by ERBB2
R-HSA-162582 Signal Transduction
R-HSA-8863795 Downregulation of ERBB2 signaling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001486 BXGD000056 Adenovirus Infections Infections
C0004114 BXGD000255 Astrocytoma Neoplasms
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0011311 BXGD000714 Dengue Fever Infections
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019061 BXGD001273 Hemolytic-Uremic Syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Hemic and Lymphatic Diseases
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0021831 BXGD001516 Intestinal Diseases Digestive System Diseases
C0023290 BXGD001631 Leishmaniasis, Visceral Infections
C0023418 BXGD001642 leukemia Neoplasms
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0162701 BXGD003978 Polysomnography
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0456889 BXGD008881 Enteropathy-Associated T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0553694 BXGD009409 Oropharyngeal disorders Digestive System Diseases; Respiratory Tract Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1319315 BXGD012415 Adenocarcinoma of large intestine Digestive System Diseases; Neoplasms
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1335167 BXGD012768 Ovarian Mucinous Adenocarcinoma Neoplasms
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1961099 BXGD016672 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C3272525 BXGD018623 Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0044857 Sp-600125 220.06
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein