Showing entry for Protein ERGIC-53


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010687
Protein NameProtein ERGIC-53
Uniport IdP49257
GeneLMAN1
Gene Id3998
DomainLectin_leg-like
Pfam PF03388  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007596 blood coagulation
Biological Process GO:0048208 COPII vesicle coating
Biological Process GO:0007029 endoplasmic reticulum organization
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0007030 Golgi organization
Biological Process GO:1903215 negative regulation of protein targeting to mitochondrion
Biological Process GO:0010638 positive regulation of organelle organization
Biological Process GO:0006457 protein folding
Biological Process GO:0018279 protein N-linked glycosylation via asparagine
Biological Process GO:0015031 protein transport
molecular function GO:0005537 mannose binding
molecular function GO:0046872 metal ion binding
molecular function GO:0051082 unfolded protein binding
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0030134 COPII-coated ER to Golgi transport vesicle
cellular component GO:0005829 cytosol
cellular component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
cellular component GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0012507 ER to Golgi transport vesicle membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0000139 Golgi membrane
cellular component GO:0044220 host cell perinuclear region of cytoplasm
cellular component GO:0016021 integral component of membrane
cellular component GO:0016020 membrane
cellular component GO:0030017 sarcomere
Reactome
Pathway Id Pathway Name
R-HSA-199977 ER to Golgi Anterograde Transport
R-HSA-199991 Membrane Trafficking
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-392499 Metabolism of proteins
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5694530 Cargo concentration in the ER
R-HSA-597592 Post-translational protein modification
R-HSA-948021 Transport to the Golgi and subsequent modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001430 BXGD000054 Adenoma Neoplasms
C0005779 BXGD000336 Blood Coagulation Disorders Hemic and Lymphatic Diseases
C0007097 BXGD000424 Carcinoma Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0017661 BXGD001139 IGA Glomerulonephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018939 BXGD001253 Hematological Disease Hemic and Lymphatic Diseases
C0019069 BXGD001277 Hemophilia A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0020517 BXGD001415 Hypersensitivity Immune System Diseases
C0024530 BXGD001783 Malaria Infections
C0027651 BXGD002009 Neoplasms Neoplasms
C0042880 BXGD003011 Vitamin K Deficiency Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0272315 BXGD006341 Coagulation factor deficiency syndrome Hemic and Lymphatic Diseases
C0272342 BXGD006352 Familial multiple factor deficiency syndrome, type I
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0883409 BXGD011395 Cardiac troponin I measurement
C1300257 BXGD012273 Thanatophoric dysplasia, type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C1306589 BXGD012369 Congenital dyserythropoietic anemia, type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1458140 BXGD013134 Bleeding tendency Hemic and Lymphatic Diseases
C1848534 BXGD014937 VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1856883 BXGD015649 FACTOR V AND FACTOR VIII, COMBINED DEFICIENCY OF Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2873785 BXGD017819 Deficiency of factor V [labile]
C3494187 BXGD018958 Factor VIII Deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C3714514 BXGD019409 Infection Infections
C4025649 BXGD021710 Reduced factor VIII activity
C4317320 BXGD022738 Factor V deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4544822 BXGD023286 Microsatellite instability-high colorectal cancer Digestive System Diseases; Neoplasms
C4551981 BXGD023463 Familial Multiple Coagulation Factor Deficiency I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein