Showing entry for Hematological Disease


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001253
Disease NameHematological Disease
Disease CUI IdC0018939
MeSH Codes C15  
Disease Class NameHemic and Lymphatic Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0001871  
Human Phenotype Ontology TermAbnormality of blood and blood-forming tissues
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A0A024RAV5 BXGT000013 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b 3845 unreviewed
O00148 BXGT003884 ATP-dependent RNA helicase DDX39A 10212 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14818 BXGT004103 Proteasome subunit alpha type-7 5688 reviewed
O15054 BXGT004121 Lysine-specific demethylase 6B 23135 reviewed Epigenetic regulator
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O60858 BXGT004903 E3 ubiquitin-protein ligase TRIM13 10206 reviewed
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic 3417 reviewed
P00390 BXGT005526 Glutathione reductase, mitochondrial 2936 reviewed Enzyme
P00492 BXGT005556 Hypoxanthine-guanine phosphoribosyltransferase 3251 reviewed Enzyme
P00519 BXGT005570 Tyrosine-protein kinase ABL1 25 reviewed Kinase
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P00734 BXGT005630 Prothrombin 2147 reviewed Enzyme
P00740 BXGT005634 Coagulation factor IX 2158 reviewed Enzyme
P00747 BXGT005639 Plasminogen 5340 reviewed Enzyme
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01112 BXGT005732 GTPase HRas 3265 reviewed Enzyme modulator
P01116 BXGT005733 GTPase KRas 3845 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01236 BXGT005744 Prolactin 5617 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02730 BXGT005935 Band 3 anion transport protein 6521 reviewed Transporter
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02786 BXGT005961 Transferrin receptor protein 1 7037 reviewed Enzyme
P04275 BXGT006180 von Willebrand factor 7450 reviewed Enzyme modulator
P04440 BXGT006216 HLA class II histocompatibility antigen, DP beta 1 chain 3115 reviewed Immune response
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P04839 BXGT006273 Cytochrome b-245 heavy chain 1536 reviewed Ion channel
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05164 BXGT006333 Myeloperoxidase 4353 reviewed Enzyme
P05187 BXGT006339 Alkaline phosphatase, placental type 250 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P07148 BXGT006559 Fatty acid-binding protein, liver 2168 reviewed
P08069 BXGT006723 Insulin-like growth factor 1 receptor 3480 reviewed Kinase
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08185 BXGT006742 Corticosteroid-binding globulin 866 reviewed Enzyme modulator
P08603 BXGT006798 Complement factor H 3075 reviewed
P08700 BXGT006816 Interleukin-3 3562 reviewed
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P10147 BXGT007543 C-C motif chemokine 3 6348 reviewed Signaling
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10323 BXGT007557 Acrosin 49 reviewed Enzyme
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P11215 BXGT007672 Integrin alpha-M 3684 reviewed
P11226 BXGT007675 Mannose-binding protein C 4153 reviewed Receptor
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11362 BXGT007693 Fibroblast growth factor receptor 1 2260 reviewed Kinase
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P12004 BXGT007766 Proliferating cell nuclear antigen 5111 reviewed Nucleic acid binding
P12277 BXGT007789 Creatine kinase B-type 1152 reviewed Kinase
P12314 BXGT007798 High affinity immunoglobulin gamma Fc receptor I 2209 reviewed Cell adhesion
P13236 BXGT007891 C-C motif chemokine 4 6351 reviewed
P13716 BXGT007948 Delta-aminolevulinic acid dehydratase 210 reviewed Enzyme
P15153 BXGT008090 Ras-related C3 botulinum toxin substrate 2 5880 reviewed Enzyme modulator
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15941 BXGT008176 Mucin-1 4582 reviewed
P16234 BXGT008209 Platelet-derived growth factor receptor alpha 5156 reviewed Kinase
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P18146 BXGT008384 Early growth response protein 1 1958 reviewed Nucleic acid binding
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P19883 BXGT008528 Follistatin 10468 reviewed Enzyme modulator
P25963 BXGT009080 NF-kappa-B inhibitor alpha 4792 reviewed
P26951 BXGT009147 Interleukin-3 receptor subunit alpha 3563 reviewed Signaling
P27487 BXGT009187 Dipeptidyl peptidase 4 1803 reviewed Enzyme
P27797 BXGT009206 Calreticulin 811 reviewed Calcium-binding protein
P28066 BXGT009227 Proteasome subunit alpha type-5 5686 reviewed
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P30536 BXGT009435 Translocator protein 706 reviewed
P30613 BXGT009447 Pyruvate kinase PKLR 5313 reviewed Kinase
P30711 BXGT009460 Glutathione S-transferase theta-1 2952 reviewed
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35222 BXGT009799 Catenin beta-1 1499 reviewed
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 2322 reviewed Kinase
P39019 BXGT010082 40S ribosomal protein S19 6223 reviewed Nucleic acid binding
P40225 BXGT010168 Thrombopoietin 7066 reviewed
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P41212 BXGT010235 Transcription factor ETV6 2120 reviewed Transcription factor
P41252 BXGT010245 Isoleucine--tRNA ligase, cytoplasmic 3376 reviewed Enzyme
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43246 BXGT010371 DNA mismatch repair protein Msh2 4436 reviewed Nucleic acid binding
P43403 BXGT010385 Tyrosine-protein kinase ZAP-70 7535 reviewed Kinase
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48735 BXGT010657 Isocitrate dehydrogenase [NADP], mitochondrial 3418 reviewed
P49257 BXGT010687 Protein ERGIC-53 3998 reviewed Transporter
P49763 BXGT010737 Placenta growth factor 5228 reviewed Signaling
P49792 BXGT010743 E3 SUMO-protein ligase RanBP2 5903 reviewed Enzyme modulator
P51580 BXGT010864 Thiopurine S-methyltransferase 7172 reviewed
P51589 BXGT010867 Cytochrome P450 2J2 1573 reviewed
P52333 BXGT010928 Tyrosine-protein kinase JAK3 3718 reviewed Kinase
P55157 BXGT011108 Microsomal triglyceride transfer protein large subunit 4547 reviewed Transporter
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60903 BXGT011339 Protein S100-A10 6281 reviewed Calcium-binding protein
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P61978 BXGT011399 Heterogeneous nuclear ribonucleoprotein K 3190 reviewed Enzyme
P62993 BXGT011480 Growth factor receptor-bound protein 2 2885 reviewed
P68036 BXGT011572 Ubiquitin-conjugating enzyme E2 L3 7332 reviewed Enzyme
P68871 BXGT011615 Hemoglobin subunit beta 3043 reviewed
P69891 BXGT011646 Hemoglobin subunit gamma-1 3047 reviewed
P69892 BXGT011647 Hemoglobin subunit gamma-2 3048 reviewed
P69905 BXGT011649 Hemoglobin subunit alpha 3040 reviewed
P78310 BXGT011830 Coxsackievirus and adenovirus receptor 1525 reviewed
P78536 BXGT011847 Disintegrin and metalloproteinase domain-containing protein 17 6868 reviewed
P81172 BXGT011935 Hepcidin 57817 reviewed
P82251 BXGT011971 b(0,+)-type amino acid transporter 1 11136 reviewed Transporter
Q01081 BXGT012566 Splicing factor U2AF 35 kDa subunit 7307 reviewed
Q01196 BXGT012575 Runt-related transcription factor 1 861 reviewed Transcription factor
Q02763 BXGT012667 Angiopoietin-1 receptor 7010 reviewed Kinase
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A 4297 reviewed
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 4170 reviewed Signaling
Q07954 BXGT012950 Prolow-density lipoprotein receptor-related protein 1 4035 reviewed
Q09472 BXGT013038 Histone acetyltransferase p300 2033 reviewed
Q12866 BXGT013273 Tyrosine-protein kinase Mer 10461 reviewed Kinase
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q13671 BXGT013391 Ras and Rab interactor 1 9610 reviewed Enzyme modulator
Q13838 BXGT013397 Spliceosome RNA helicase DDX39B 7919 reviewed
Q13951 BXGT013407 Core-binding factor subunit beta 865 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase 7486 reviewed Enzyme
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 9970 reviewed Nuclear receptor
Q15554 BXGT013577 Telomeric repeat-binding factor 2 7014 reviewed
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q6N021 BXGT016378 Methylcytosine dioxygenase TET2 54790 reviewed
Q76LX8 BXGT016870 A disintegrin and metalloproteinase with thrombospondin motifs 13 11093 reviewed Enzyme
Q7L266 BXGT016993 Isoaspartyl peptidase/L-asparaginase 80150 reviewed Enzyme
Q8NBL1 BXGT018539 Protein O-glucosyltransferase 1 56983 reviewed
Q8NI22 BXGT018571 Multiple coagulation factor deficiency protein 2 90411 reviewed Transporter
Q92743 BXGT019368 Serine protease HTRA1 5654 reviewed Enzyme
Q92793 BXGT019374 CREB-binding protein 1387 reviewed
Q96P20 BXGT019704 NACHT, LRR and PYD domains-containing protein 3 114548 reviewed
Q99707 BXGT019952 Methionine synthase 4548 reviewed
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9H0A0 BXGT020434 RNA cytidine acetyltransferase 55226 reviewed
Q9NR96 BXGT021181 Toll-like receptor 9 54106 reviewed
Q9NZD4 BXGT021271 Alpha-hemoglobin-stabilizing protein 51327 reviewed Chaperone
Q9UBB5 BXGT021649 Methyl-CpG-binding domain protein 2 8932 reviewed Epigenetic regulator
Q9UBN7 BXGT021658 Histone deacetylase 6 10013 reviewed Epigenetic regulator
Q9UKV5 BXGT021751 E3 ubiquitin-protein ligase AMFR 267 reviewed
Q9UM73 BXGT021773 ALK tyrosine kinase receptor 238 reviewed Kinase
Q9UMF0 BXGT021774 Intercellular adhesion molecule 5 7087 reviewed
Q9Y2D1 BXGT022230 Cyclic AMP-dependent transcription factor ATF-5 22809 reviewed
Q9Y2R2 BXGT022243 Tyrosine-protein phosphatase non-receptor type 22 26191 reviewed
Q9Y6K1 BXGT022331 DNA (cytosine-5)-methyltransferase 3A 1788 reviewed
P38646 BXGT024954 Stress-70 protein, mitochondrial 3313 reviewed
Q9UNE7 BXGT025000 E3 ubiquitin-protein ligase CHIP 10273 reviewed
P19474 BXGT025520 E3 ubiquitin-protein ligase TRIM21 6737 reviewed
Q96AE4 BXGT025980 Far upstream element-binding protein 1 8880 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease