protein

Showing entry for Estrogen receptor

General Target Information
BXGT Id	BXGT010754
Protein Name	Estrogen receptor
Uniport Id	P49884
Gene	ESR1
Gene Id	407238
Domain	ESR1_C; Hormone_recep; Oest_recep; zf-C4
Pfam	PF12743 PF00104 PF02159 PF00105
Organism	Bos taurus (Bovine)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0008209	androgen metabolic process
Biological Process	GO:0001547	antral ovarian follicle growth
Biological Process	GO:0071392	cellular response to estradiol stimulus
Biological Process	GO:0071391	cellular response to estrogen stimulus
Biological Process	GO:0002064	epithelial cell development
Biological Process	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway
Biological Process	GO:0030518	intracellular steroid hormone receptor signaling pathway
Biological Process	GO:0008584	male gonad development
Biological Process	GO:0060749	mammary gland alveolus development
Biological Process	GO:0060745	mammary gland branching involved in pregnancy
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
Biological Process	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity
Biological Process	GO:0048146	positive regulation of fibroblast proliferation
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity
Biological Process	GO:0010863	positive regulation of phospholipase C activity
Biological Process	GO:0045899	positive regulation of RNA polymerase II transcription preinitiation complex assembly
Biological Process	GO:0045893	positive regulation of transcription, DNA-templated
Biological Process	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
Biological Process	GO:0060523	prostate epithelial cord elongation
Biological Process	GO:0071168	protein localization to chromatin
Biological Process	GO:0042981	regulation of apoptotic process
Biological Process	GO:0060687	regulation of branching involved in prostate gland morphogenesis
Biological Process	GO:0050727	regulation of inflammatory response
Biological Process	GO:0034121	regulation of toll-like receptor signaling pathway
Biological Process	GO:0048863	stem cell differentiation
Biological Process	GO:0060065	uterus development
Biological Process	GO:0060068	vagina development
molecular function	GO:0051117	ATPase binding
molecular function	GO:0008013	beta-catenin binding
molecular function	GO:0003682	chromatin binding
molecular function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function	GO:0030284	estrogen receptor activity
molecular function	GO:0030331	estrogen receptor binding
molecular function	GO:0034056	estrogen response element binding
molecular function	GO:0042802	identical protein binding
molecular function	GO:0004879	nuclear receptor activity
molecular function	GO:0019901	protein kinase binding
molecular function	GO:0070491	repressing transcription factor binding
molecular function	GO:0001226	RNA polymerase II transcription corepressor binding
molecular function	GO:0043565	sequence-specific DNA binding
molecular function	GO:0005496	steroid binding
molecular function	GO:0017025	TBP-class protein binding
molecular function	GO:0001093	TFIIB-class transcription factor binding
molecular function	GO:0001223	transcription coactivator binding
molecular function	GO:0008270	zinc ion binding
cellular component	GO:0005794	Golgi apparatus
cellular component	GO:0000790	nuclear chromatin
cellular component	GO:0005634	nucleus
cellular component	GO:0005886	plasma membrane
cellular component	GO:0035327	transcriptionally active chromatin
cellular component	GO:0097550	transcription preinitiation complex

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000130	Estradiol		272.38
BXGC0002627	17alpha-ethynylestradiol		296.4
BXGC0003707	Estrogen		268.36
BXGC0006362	Estrone		270.37
BXGC0033999	Zuclomiphene		405.19

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}