Showing entry for Estrone


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0006362
Compound NameEstrone
Structure
FormulaC18H22O2
InchiKeyDNXHEGUUPJUMQT-CBZIJGRNSA-N
SMILES[H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
InchiInChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
IUPAC(1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7.0.02,?.011,1?]heptadeca-2(7),3,5-trien-14-one
Molecular Weight270.37
Pubchem Id5870
Chembl IdCHEMBL1405
Targets of Information Source
DrugBank DB00655
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 approved agonist
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 approved -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR approved -
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 approved -
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG approved -
PDB J3Z
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P03372 BXGT006059 Estrogen receptor reviewed ESR1 Nuclear receptor - - - -
Q9BPX1 BXGT020103 17-beta-hydroxysteroid dehydrogenase 14 reviewed HSD17B14 Enzyme - - - -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed HSD17B1 Enzyme - - - -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed HSD17B1 Enzyme - - 1600 -
Binding DB 17289
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 29 - 166
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 31 - 26
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 480 - 0.7
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 1135 - 2.1
reviewed BXGT019744 Ghrelin O-acyltransferase reviewed MBOAT4 - >1.000e+6 - -
reviewed BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 - 3000 - -
reviewed BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 - 810 - -
reviewed BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 - 600 - -
reviewed BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 3 - - -
reviewed BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 - >50000 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 210 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 540 - -
reviewed BXGT006830 Steryl-sulfatase reviewed Enzyme STS - 51000 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 120
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 120
reviewed BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 - 330 - -
reviewed BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 - 218 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 7
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - - - 8
reviewed BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 - 109 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 96 - -
reviewed BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 9500 - - -
reviewed BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 - >10000 - -
reviewed BXGT010535 Solute carrier organic anion transporter family member 1A1 reviewed Slco1a1 15700 - - -
reviewed BXGT006182 Sex hormone-binding globulin reviewed SHBG - - 6.6 -
CHEMBL CHEMBL1405
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 15848 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 1258 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterus weight '=' 53 mg
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterus weight '=' 53 mg
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 IC50 '=' 3000 nM
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 Activity '=' 70 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio '=' 0 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio '=' 0 -
O75897 BXGT005160 Sulfotransferase 1C4 reviewed - SULT1C4 Activity - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ka '=' 821000000 M-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ka '=' 821000000 M-1
Q9BPX1 BXGT020103 17-beta-hydroxysteroid dehydrogenase 14 reviewed Enzyme HSD17B14 Delta Tm '=' 1 degrees C
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 109 %
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 15 nM
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Activity '=' 49 pm/min/mg
P54855 BXGT011088 UDP-glucuronosyltransferase 2B15 reviewed - UGT2B15 Activity '=' 0 pm/min/mg
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki '=' 2100 nM
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 15848 nM
P06133 BXGT006414 UDP-glucuronosyltransferase 2B4 reviewed - UGT2B4 Activity '=' 0 pm/min/mg
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 47 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 47 -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 8 %
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 40 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 40 -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Ki '=' 9500 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 3 %
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterine weight '=' 59 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterine weight '=' 59 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 46 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 46 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 37 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 37 -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 83 %
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 46 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 46 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 39 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 39 -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Activity - - -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterine weight '=' 69 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterine weight '=' 69 -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 Activity '=' 56 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 8 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterus weight '=' 55 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterus weight '=' 55 -
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Activity '=' 79 pm/min/mg
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity '=' 0 pm/min/mg
P0DTE4 BXGT022286 UDP-glucuronosyltransferase 2A1 reviewed - UGT2A1 Activity '=' 0 pm/min/mg
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG Log 1/K '=' -8 -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 14581 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 7 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 94 %
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Km '=' 4600 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 3548 nM
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 40 pm/min/mg
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 1 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 0 pm/min/mg
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 96 nM
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Ki '=' 10000 nM
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 35 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 35 -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 36 %
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 19 %
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterus weight '=' 59 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterus weight '=' 59 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterus weight '=' 56 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterus weight '=' 56 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 46 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 46 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 38 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 38 -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 6309 nM
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 RBA '=' 7 -
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 RBA '=' 7 -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 '=' 6589 nM
P0A6C1 BXGT007045 Endonuclease 4 reviewed - nfo Potency '=' 31622 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterine weight '=' 54 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterine weight '=' 54 -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 IC50 '=' 109 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki '=' 7745 nM
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 IC50 '=' 218 nM
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 42 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 42 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 46 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 46 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 29 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency '=' 3981 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 RBA '=' 23 -
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 RBA '=' 23 -
P49888 BXGT010756 Estrogen sulfotransferase reviewed - SULT1E1 Activity - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
Q13148 BXGT013318 TAR DNA-binding protein 43 reviewed - TARDBP Potency - 4466 nM
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
Q63449 BXGT016072 Progesterone receptor reviewed - Pgr Fold induction '=' 1 -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 540 nM
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 59 %
P37059 BXGT009957 Estradiol 17-beta-dehydrogenase 2 reviewed Enzyme HSD17B2 Inhibition - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 4 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 nM
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 37 %
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 IC50 '=' 600 nM
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG Kd '=' 6 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 45 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 45 -
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 RBA '=' 15 -
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 RBA '=' 15 -
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 Ratio '=' 2 -
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 Ratio '=' 2 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 39 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 39 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterus weight '=' 53 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterus weight '=' 53 -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 85 %
Q9HAW7 BXGT020508 UDP-glucuronosyltransferase 1-7 reviewed - UGT1A7 Activity '=' 0 pm/min/mg
Q53GQ0 BXGT015013 Very-long-chain 3-oxoacyl-CoA reductase reviewed - HSD17B12 Inhibition '=' 0 %
O95398 BXGT005378 Rap guanine nucleotide exchange factor 3 reviewed Enzyme modulator RAPGEF3 Potency - 112201 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterus weight '=' 45 mg
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterus weight '=' 45 mg
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterus weight '=' 54 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterus weight '=' 54 -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 11 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 37 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 37 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 11 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 28183 nM
Q06520 BXGT012880 Bile salt sulfotransferase reviewed - SULT2A1 Activity - - -
P15289 BXGT008102 Arylsulfatase A reviewed Enzyme ARSA Potency - 952 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P56937 BXGT011205 3-keto-steroid reductase reviewed - HSD17B7 Inhibition '=' 10 %
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki '=' 2816 nM
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 210 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 100000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RSA '=' 4 %
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RSA '=' 4 %
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Log K '=' 5 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 RBA '=' 30 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 30 -
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 199 nM
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 39 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 39 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 44 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 44 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 480 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P56937 BXGT011205 3-keto-steroid reductase reviewed - HSD17B7 Inhibition '=' 0 %
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterine weight '=' 53 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterine weight '=' 53 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 ED50 '=' 0 uM
Q9BR01 BXGT020115 Sulfotransferase 4A1 reviewed - SULT4A1 Activity - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Activity '=' 0 pm/min/mg
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki '=' 8676 nM
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 1995 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Estrogenic potency '=' 12 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Estrogenic potency '=' 12 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterine weight '=' 64 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterine weight '=' 64 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 39 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 39 -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 49 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 49 -
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity '=' 11 pm/min/mg
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Activity '=' 0 pm/min/mg
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 17782 nM
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Log 1/K '=' 5 -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 90 %
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Relative binding affinity '=' 9 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Relative binding affinity '=' 9 %
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 93 %
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 2685 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 ED50 '=' 0 uM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 48 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 48 -
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 100000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 120 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Weight '=' -120 mg
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Weight '=' -120 mg
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterine weight '=' 55 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterine weight '=' 55 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 46 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 46 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 31 nM
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG Log 1/K '=' 8 -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 IC50 '=' 810 nM
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 7 nM
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 IC50 '>' 50000 nM
Q63449 BXGT016072 Progesterone receptor reviewed - Pgr Fold induction '=' 24 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio EC50 '=' 6 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio EC50 '=' 6 -
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 #NAME? '=' 4 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 RBA '=' 1960 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 1960 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterine weight '=' 45 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterine weight '=' 45 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 39 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 39 -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 41 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 41 -
P08185 BXGT006742 Corticosteroid-binding globulin reviewed Enzyme modulator SERPINA6 Log 1/K '=' -5 -
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 4466 nM
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterus weight '=' 48 mg
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterus weight '=' 48 mg
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterus weight '=' 48 mg
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterus weight '=' 48 mg
P46720 BXGT010535 Solute carrier organic anion transporter family member 1A1 reviewed - Slco1a1 Ki '=' 15700 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition '=' 38 %
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 120 nM
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Inhibition - - -
Q9GK37 BXGT020404 Corticosteroid-binding globulin reviewed - Serpina6 Log 1/K '=' 5 -
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 IC50 '=' 330 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 - - -
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 Activity - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 26 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio IC50 '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio IC50 '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 166 nM
P54803 BXGT011082 Galactocerebrosidase reviewed - GALC Potency - 631 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterus weight '=' 46 mg
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterus weight '=' 46 mg
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 40 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 40 -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 23109 nM
P56937 BXGT011205 3-keto-steroid reductase reviewed - HSD17B7 Inhibition - - -
O75795 BXGT005152 UDP-glucuronosyltransferase 2B17 reviewed - UGT2B17 Activity '=' 0 pm/min/mg
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 '=' 5301 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 47 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 47 -
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 reviewed Transporter ABCG2 IC50 '>' 10000 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 2 nM
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 '=' 16098 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 Inhibition '=' 16 %
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 2 nM
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 '=' 13630 nM
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 '=' 11617 nM
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Activity - - -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 280 %
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 0 pm/min/mg
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P11511 BXGT007717 Aromatase reviewed Enzyme CYP19A1 Ki '=' 2500 nM
P14061 BXGT007979 Estradiol 17-beta-dehydrogenase 1 reviewed Enzyme HSD17B1 Ki '=' 3 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Relative uterus weight '=' 47 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Relative uterus weight '=' 47 -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P08842 BXGT006830 Steryl-sulfatase reviewed Enzyme STS IC50 '=' 51000 nM
P19785 BXGT008514 Estrogen receptor reviewed - Esr1 Effect '=' 45 -
O08537 BXGT004028 Estrogen receptor beta reviewed - Esr2 Effect '=' 45 -
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG #NAME? '=' 7 -
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '>' 1000000 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 29092 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 1135 nM
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 Inhibition '=' 40 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00105 Apple Malus pumila Fruits
BXGF00121 Olive Olea europaea Vegetables
BXGF00134 Common bean Phaseolus vulgaris Pulses
BXGF00135 Date Phoenix dactylifera Fruits
BXGF00144 Apricot Prunus armeniaca Fruits
BXGF00151 Pomegranate Punica granatum Fruits
BXGF00205 Corn Zea mays Cereals and cereal products
BXGF00823 Fruits Fruits
BXGF01304 Conyza canadensis Conyza canadensis Medicinal Plant
BXGF01362 Coreopsis fasciculata Coreopsis fasciculata Others
BXGF01601 Selinum carvifolium Selinum carvifolium Others
BXGF02254 Thuja plicata Thuja plicata Medicinal Plant
BXGF02970 Crepis foetida Crepis foetida Medicinal Plant
BXGF03014 Cirsium japonicum Cirsium japonicum Medicinal Plant
BXGF03039 Dorstenia lindeniana Dorstenia lindeniana Others
BXGF03059 Dioscoreophyllum cumminsii Dioscoreophyllum cumminsii Medicinal Plant
BXGF03121 Phytolacca acinosa Phytolacca acinosa Medicinal Plant
BXGF03140 Garcinia hombroniana Garcinia hombroniana Medicinal Plant
BXGF03192 Cardiospermum halicacabum Cardiospermum halicacabum Medicinal Plant
BXGF03213 Aglaia elaeagnoidea Aglaia elaeagnoidea Human Edible Plant
BXGF03272 Urtica triangularis Urtica triangularis Human Edible Plant
BXGF03320 Pouzolzia occidentalis Pouzolzia occidentalis Others
BXGF03344 Centaurea nigrescens Centaurea nigrescens Human Edible Plant
BXGF03400 Piper arboreum Piper arboreum Medicinal Plant
BXGF03431 Parastrephia lepidophylla Parastrephia lepidophylla Others
BXGF03445 Phlogacanthus thyrsiflorus Phlogacanthus thyrsiflorus Medicinal Plant
BXGF03455 Euphorbia segetalis Euphorbia segetalis Others
BXGF03465 Sidastrum acuminatum Sidastrum acuminatum Others
BXGF03480 Syncolostemon parviflorus Syncolostemon parviflorus Others
BXGF03491 Aristolochia elegans Aristolochia elegans Others
BXGF03503 Penstemon secundiflorus Penstemon secundiflorus Others
BXGF03541 Cuphea carthagenensis Cuphea carthagenensis Others
BXGF03552 Ozoroa insignis Ozoroa insignis Medicinal Plant
BXGF03571 Ruta microcarpa Ruta microcarpa Medicinal Plant
BXGF03579 Crinum defixum Crinum defixum Medicinal Plant
BXGF03742 Zanthoxylum monophyllum Zanthoxylum monophyllum Others
BXGF04756 Astragalus gummifer Astragalus gummifer Medicinal Plant
BXGF04890 Triglochin maritima Triglochin maritima Medicinal Plant
BXGF05640 Phedimus kamtschaticus Phedimus kamtschaticus Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease