Showing entry for 17alpha-ethynylestradiol


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0002627
Compound Name17alpha-ethynylestradiol
Structure
FormulaC20H24O2
InchiKeyBFPYWIDHMRZLRN-SLHNCBLASA-N
SMILES[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
InchiInChI=1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1
IUPAC(1S,10R,11S,14R,15S)-14-ethynyl-15-methyltetracyclo[8.7.0.02,?.011,1?]heptadeca-2(7),3,5-triene-5,14-diol
Molecular Weight296.4
Pubchem Id5991
Chembl IdCHEMBL691
Targets of Information Source
DrugBank DB00977
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 approved agonist
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 reviewed Nuclear receptor NR1I2 approved agonist
PDB 3WF
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 reviewed NR1I2 Nuclear receptor 11500 - - -
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 reviewed NR1I2 Nuclear receptor - - 11500 -
Binding DB 50187243
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008603 Cytochrome P450 2B6 reviewed CYP2B6 900 - - -
reviewed BXGT008940 3-oxo-5-alpha-steroid 4-dehydrogenase 1 reviewed Srd5a1 - 960000 - -
reviewed BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 3600 - - -
reviewed BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 430 - - -
reviewed BXGT010781 Sulfotransferase 1A1 reviewed SULT1A1 - - 500 -
reviewed BXGT010781 Sulfotransferase 1A1 reviewed SULT1A1 - 20 - -
reviewed BXGT010781 Sulfotransferase 1A1 reviewed SULT1A1 19 - - -
reviewed BXGT010781 Sulfotransferase 1A1 reviewed SULT1A1 8.9 - - -
reviewed BXGT010781 Sulfotransferase 1A1 reviewed SULT1A1 15 - - -
reviewed BXGT010781 Sulfotransferase 1A1 reviewed SULT1A1 - - 4.3 -
reviewed BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed UGT1A1 - 44000 - -
reviewed BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed UGT1A1 - 21000 - -
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - 2 - -
reviewed BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 - 8.1 - -
reviewed BXGT013519 Nuclear receptor subfamily 1 group I member 3 reviewed Nuclear receptor NR1I3 - 3000 - -
reviewed BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 - 570 - -
reviewed BXGT006424 Estrogen receptor reviewed Esr1 - - - 1680
reviewed BXGT006424 Estrogen receptor reviewed Esr1 - - - >33700
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 1340
reviewed BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 - - - 3370
reviewed BXGT008096 Androgen receptor reviewed Ar - 8128.31 - -
reviewed BXGT008603 Cytochrome P450 2B6 reviewed CYP2B6 800 - - -
reviewed BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 18000 - - -
reviewed BXGT005479 Cytochrome P450 2B1 reviewed Cyp2b1 11000 - - -
reviewed BXGT006182 Sex hormone-binding globulin reviewed SHBG - - 155 -
reviewed BXGT017618 Multidrug and toxin extrusion protein 2 reviewed Transporter SLC47A2 - 20200 - -
reviewed BXGT019660 Multidrug and toxin extrusion protein 1 reviewed Transporter SLC47A1 - 21100 - -
reviewed BXGT004140 Solute carrier family 22 member 2 reviewed Transporter SLC22A2 - 2200 - -
CHEMBL CHEMBL691
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q9R1A7 BXGT021413 Nuclear receptor subfamily 1 group I member 2 reviewed - Nr1i2 Potency - 44668 nM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Estrogenic potency '=' 100 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Estrogenic potency '=' 100 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 RBA '=' 17300 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 17300 -
O35627 BXGT004535 Nuclear receptor subfamily 1 group I member 3 reviewed - Nr1i3 Activity '<' 50 %
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 - - -
P00176 BXGT005479 Cytochrome P450 2B1 reviewed - Cyp2b1 Partition ratio '=' 21 -
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 13 %
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 '=' 20931 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 '=' 32925 nM
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 mechanism based inhibition - - -
P56937 BXGT011205 3-keto-steroid reductase reviewed - HSD17B7 Inhibition '=' 3 %
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 350 pm/min/mg
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 '=' 1634 nM
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Activity '=' 160 pm/min/mg
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
O35627 BXGT004535 Nuclear receptor subfamily 1 group I member 3 reviewed - Nr1i3 FC '=' 2 -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Increase '=' 219 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Increase '=' 219 %
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Increase '=' 213 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Increase '=' 213 %
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 '=' 5678 nM
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
Q63120 BXGT016061 Canalicular multispecific organic anion transporter 1 reviewed - Abcc2 Activity - - -
O35627 BXGT004535 Nuclear receptor subfamily 1 group I member 3 reviewed - Nr1i3 Activity '>=' 50 %
O35627 BXGT004535 Nuclear receptor subfamily 1 group I member 3 reviewed - Nr1i3 Activity '>' 30 %
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Activity '=' 0 pm/min/mg
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 RBA '=' 272 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 272 -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki '=' 139 nM
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity - - -
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Ki '=' 8 nM
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Kd '=' 4 nM
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Vmax '=' 11 pmol/min/ug
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki '=' 444 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P06133 BXGT006414 UDP-glucuronosyltransferase 2B4 reviewed - UGT2B4 Activity '=' 0 pm/min/mg
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 8 nM
Q5T3U5 BXGT015846 Multidrug resistance-associated protein 7 reviewed Transporter ABCC10 Activity '=' 51 %
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 '=' 8128 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 RBA '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 RBA '=' 1 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Weight '=' -120 mg
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Weight '=' -120 mg
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Activity - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Activity - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 RBA '=' 122 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 122 -
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Activity '=' 0 pm/min/mg
P56937 BXGT011205 3-keto-steroid reductase reviewed - HSD17B7 Inhibition '=' 8 %
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki '=' 29 nM
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 22387 nM
P20813 BXGT008603 Cytochrome P450 2B6 reviewed - CYP2B6 Kinact '=' 0 min-1
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Kinact '=' 0 min-1
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 25118 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 2 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P10632 BXGT007592 Cytochrome P450 2C8 reviewed - CYP2C8 Inhibition '<' 10 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 '=' 1710 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki '=' 777 nM
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Vmax '=' 650 pmol/min/mg protein
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Gain '=' 345 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Gain '=' 345 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki '=' 951 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Estrogenic effect '=' 100 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Estrogenic effect '=' 100 -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 1 ug.mL-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 1 ug.mL-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 EC50 '=' 0 ug.mL-1
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 EC50 '=' 0 ug.mL-1
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 FC '=' 19 -
O35627 BXGT004535 Nuclear receptor subfamily 1 group I member 3 reviewed - Nr1i3 Activity '>' 150 %
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG RBA '=' 1 -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 17 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ratio IC50 '=' 63 -
Q9TU15 BXGT021625 Estrogen receptor beta reviewed - ESR2 RBA '=' 270 -
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 RBA '=' 270 -
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 14 nM
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 140 pm/min/mg
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Vmax '=' 59 pmol/min/mg protein
O35627 BXGT004535 Nuclear receptor subfamily 1 group I member 3 reviewed - Nr1i3 Activity '=' 50 %
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Weight '=' 78 mg
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Weight '=' 78 mg
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 '=' 8 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 12 nM
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ratio IC50 '=' 126 -
O35627 BXGT004535 Nuclear receptor subfamily 1 group I member 3 reviewed - Nr1i3 Activity '=' 60 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 21136 nM
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 RBA '=' 100 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 100 %
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 RBA '=' 100 -
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 RBA '=' 100 -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 11751 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '=' 18610 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P20813 BXGT008603 Cytochrome P450 2B6 reviewed - CYP2B6 Ki '=' 800 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 36 pm/min/mg
P22310 BXGT008754 UDP-glucuronosyltransferase 1-4 reviewed - UGT1A4 Activity '=' 9 pm/min/mg
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Uterotrophic effect '=' 100 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Uterotrophic effect '=' 100 -
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 IC50 '=' 570 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Inhibition '<' 10 %
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Inhibition '=' 27 %
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 '=' 7953 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 - - -
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 12589 nM
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG RBA '=' 0 -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P36537 BXGT009924 UDP-glucuronosyltransferase 2B10 reviewed - UGT2B10 Activity '=' 0 pm/min/mg
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 NSB '=' 1 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 NSB '=' 1 -
Q96FL8 BXGT019660 Multidrug and toxin extrusion protein 1 reviewed Transporter SLC47A1 IC50 '=' 21100 nM
Q86VL8 BXGT017618 Multidrug and toxin extrusion protein 2 reviewed Transporter SLC47A2 IC50 '=' 20200 nM
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 IC50 '=' 44000 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 EC50 '=' 0 ug.mL-1
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 EC50 '=' 0 ug.mL-1
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
Q9TU15 BXGT021625 Estrogen receptor beta reviewed - ESR2 RBA '=' 112 -
P49885 BXGT010755 Estrogen receptor reviewed - ESR1 RBA '=' 112 -
O35627 BXGT004535 Nuclear receptor subfamily 1 group I member 3 reviewed - Nr1i3 FC '=' 27 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Weight '=' 85 mg
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Weight '=' 85 mg
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 RBA '=' 112 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 112 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 BSI '=' 231 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 BSI '=' 231 -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
P02773 BXGT005958 Alpha-fetoprotein reviewed - Afp RBA '=' 3 -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Inhibition - - -
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 Activity '=' 53 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P04278 BXGT006182 Sex hormone-binding globulin reviewed - SHBG Kd '=' 154 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki '=' 18000 nM
P26435 BXGT009113 Sodium/bile acid cotransporter reviewed - Slc10a1 Activity - - -
P49888 BXGT010756 Estrogen sulfotransferase reviewed - SULT1E1 Activity - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 EC50 '>' 10 ug.mL-1
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 EC50 '>' 10 ug.mL-1
P49884 BXGT010754 Estrogen receptor reviewed - ESR1 Ratio '=' 1 -
Q9XSB5 BXGT022188 Estrogen receptor beta reviewed - ESR2 Ratio '=' 1 -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 DOSE '=' 100 mg.kg-1
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 DOSE '=' 100 mg.kg-1
P00176 BXGT005479 Cytochrome P450 2B1 reviewed - Cyp2b1 Ki '=' 11000 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 61 %
P00176 BXGT005479 Cytochrome P450 2B1 reviewed - Cyp2b1 Kinact '=' 0 min-1
P20813 BXGT008603 Cytochrome P450 2B6 reviewed - CYP2B6 Partition ratio '=' 13 -
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ratio Ki '=' 10 -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 14963 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Weight '=' - -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Weight '=' - -
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Activity '=' 0 pm/min/mg
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Km '=' 9000 nM
O15244 BXGT004140 Solute carrier family 22 member 2 reviewed Transporter SLC22A2 IC50 '=' 2200 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 MED '=' 0 mg kg-1
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 MED '=' 0 mg kg-1
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition '=' 18 %
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ratio IC50 '=' 2 -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Activity - - -
P20813 BXGT008603 Cytochrome P450 2B6 reviewed - CYP2B6 Ki '=' 900 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 3981 nM
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 '=' 959 nM
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 RBA '=' 191 %
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 RBA '=' 191 %
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 '=' 25894 nM
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki '=' 10867 nM
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Ki '=' 19 nM
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 '=' 1067 nM
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P24008 BXGT008940 3-oxo-5-alpha-steroid 4-dehydrogenase 1 reviewed - Srd5a1 IC50 '=' 960000 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 '=' 54 nM
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ki '=' 430 nM
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ratio Ki '=' 8 -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity - - -
P54855 BXGT011088 UDP-glucuronosyltransferase 2B15 reviewed - UGT2B15 Activity '=' 0 pm/min/mg
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 128 %
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Km '=' 20000 nM
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 reviewed Nuclear receptor NR1I3 Activity - - -
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Activity '=' 40 pm/min/mg
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki '=' 0 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 '=' 0 nM
P20813 BXGT008603 Cytochrome P450 2B6 reviewed - CYP2B6 Kinact '=' 0 min-1
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '=' 330 pm/min/mg
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki '=' 10358 nM
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
O70127 BXGT005057 Bile salt export pump reviewed - Abcb11 Activity - - -
Q96FL8 BXGT019660 Multidrug and toxin extrusion protein 1 reviewed Transporter SLC47A1 Inhibition '=' 60 %
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Activity '<=' 140 %
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Inhibition - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Partition ratio '=' 50 -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
Q06278 BXGT012869 Aldehyde oxidase reviewed Enzyme AOX1 Ki '=' 3600 nM
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Kd '=' 500 nM
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 '=' 26769 nM
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 '=' 559 nM
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki '=' 1326 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki '=' 1090 nM
P20813 BXGT008603 Cytochrome P450 2B6 reviewed - CYP2B6 Inhibition '<' 10 %
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '<' 10000 nM
Q62986 BXGT016053 Estrogen receptor beta reviewed - Esr2 Activity - - -
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity - - -
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Ki '=' 14 nM
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Km '=' 690 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 3 nM
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 IC50 '=' 20 nM
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 IC50 '=' 133000 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 IC50 '=' 21000 nM
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 reviewed Nuclear receptor NR1I3 IC50 '=' 3000 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ratio '=' 0 /uM/min
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Inhibition '=' 65 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition '<' 10 %
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 133000 nM
P50225 BXGT010781 Sulfotransferase 1A1 reviewed - SULT1A1 Km '=' 450 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 14000 nM
P06211 BXGT006424 Estrogen receptor reviewed - Esr1 Activity '=' 350 %
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00006 Garden onion Allium cepa Vegetables
BXGF00013 Dill Anethum graveolens Herbs and Spices
BXGF00015 Wild celery Apium graveolens Herbs and Spices
BXGF00017 Burdock Arctium lappa Vegetables
BXGF00018 Horseradish Armoracia rusticana Herbs and Spices
BXGF00019 Tarragon Artemisia dracunculus Herbs and Spices
BXGF00020 Mugwort Artemisia vulgaris Herbs and Spices
BXGF00027 Chinese mustard Brassica juncea Vegetables
BXGF00033 Kohlrabi Brassica oleracea var. gongylodes Vegetables
BXGF00038 Tea Camellia sinensis Teas
BXGF00040 Pepper (C. annuum) Capsicum annuum Vegetables
BXGF00041 Papaya Carica papaya Fruits
BXGF00043 Caraway Carum carvi Herbs and Spices
BXGF00046 Roman camomile Chamaemelum nobile Herbs and Spices
BXGF00050 Chinese cinnamon Cinnamomum aromaticum Herbs and Spices
BXGF00051 Ceylon cinnamon Cinnamomum verum Herbs and Spices
BXGF00053 Lime Citrus aurantiifolia Fruits
BXGF00054 Lemon Citrus limon Fruits
BXGF00056 Mandarin orange (Clementine, Tangerine) Citrus reticulata Fruits
BXGF00057 Sweet orange Citrus sinensis Fruits
BXGF00059 Arabica coffee Coffea arabica Coffee and coffee products
BXGF00061 Coriander Coriandrum sativum Herbs and Spices
BXGF00063 Saffron Crocus sativus Herbs and Spices
BXGF00067 Cumin Cuminum cyminum Herbs and Spices
BXGF00068 Turmeric Curcuma longa Herbs and Spices
BXGF00070 Lemon grass Cymbopogon citratus Herbs and Spices
BXGF00072 Wild carrot Daucus carota Vegetables
BXGF00074 Cardamom Elettaria cardamomum Herbs and Spices
BXGF00081 Fig Ficus carica Fruits
BXGF00082 Fennel Foeniculum vulgare Herbs and Spices
BXGF00086 Sunflower Helianthus annuus Herbs and Spices
BXGF00089 Hyssop Hyssopus officinalis Herbs and Spices
BXGF00090 Star anise Illicium verum Herbs and Spices
BXGF00094 Common walnut Juglans regia Nuts
BXGF00097 Sweet bay Laurus nobilis Herbs and Spices
BXGF00099 Garden cress Lepidium sativum Vegetables
BXGF00100 Lovage Levisticum officinale Herbs and Spices
BXGF00105 Apple Malus pumila Fruits
BXGF00106 Mango Mangifera indica Fruits
BXGF00107 German camomile Matricaria recutita Herbs and Spices
BXGF00108 Lemon balm Melissa officinalis Herbs and Spices
BXGF00110 Orange mint Mentha aquatica Herbs and Spices
BXGF00111 Cornmint Mentha arvensis Herbs and Spices
BXGF00112 Spearmint Mentha spicata Herbs and Spices
BXGF00113 Peppermint Mentha X piperita Herbs and Spices
BXGF00118 Nutmeg Myristica fragrans Herbs and Spices
BXGF00119 Sweet basil Ocimum basilicum Herbs and Spices
BXGF00122 Sweet marjoram Origanum majorana Herbs and Spices
BXGF00123 Pot marjoram Origanum onites Herbs and Spices
BXGF00124 Common oregano Origanum vulgare Herbs and Spices
BXGF00128 Passion fruit Passiflora edulis Fruits
BXGF00130 Avocado Persea americana Vegetables
BXGF00131 Parsley Petroselinum crispum Herbs and Spices
BXGF00137 Anise Pimpinella anisum Herbs and Spices
BXGF00139 Pepper (Spice) Piper nigrum Herbs and Spices
BXGF00144 Apricot Prunus armeniaca Fruits
BXGF00146 Sour cherry Prunus cerasus Fruits
BXGF00148 Almond Prunus dulcis Nuts
BXGF00150 Guava Psidium guajava Fruits
BXGF00154 Garden rhubarb Rheum rhabarbarum Vegetables
BXGF00155 Blackcurrant Ribes nigrum Fruits
BXGF00158 Watercress Rorippa nasturtium-aquaticum Herbs and Spices
BXGF00159 Rosemary Rosmarinus officinalis Herbs and Spices
BXGF00165 Common sage Salvia officinalis Herbs and Spices
BXGF00166 Black elderberry Sambucus nigra Fruits
BXGF00167 Summer savory Satureja hortensis Herbs and Spices
BXGF00168 Winter savory Satureja montana Herbs and Spices
BXGF00175 Potato Solanum tuberosum Vegetables
BXGF00179 Cloves Syzygium aromaticum Herbs and Spices
BXGF00181 Dandelion Taraxacum officinale Herbs and Spices
BXGF00182 Cocoa bean Theobroma cacao Cocoa and cocoa products
BXGF00183 Common thyme Thymus vulgaris Herbs and Spices
BXGF00186 Fenugreek Trigonella foenum-graecum Herbs and Spices
BXGF00196 Common verbena Verbena officinalis Herbs and Spices
BXGF00205 Corn Zea mays Cereals and cereal products
BXGF00206 Ginger Zingiber officinale Herbs and Spices
BXGF00230 Carrot Daucus carota ssp. sativus Vegetables
BXGF00265 Allspice Pimenta dioica Herbs and Spices
BXGF00302 Chervil Anthriscus cerefolium Herbs and Spices
BXGF00337 Ginkgo nuts Ginkgo biloba Herbs and Spices
BXGF00380 White mustard Sinapis alba Herbs and Spices
BXGF00393 Pepper (C. frutescens) Capsicum annuum var. annuum Vegetables
BXGF00802 Soft-necked garlic Allium sativum L. var. sativum Herbs and Spices
BXGF00829 Green bell pepper Capsicum annuum Vegetables
BXGF00830 Yellow bell pepper Capsicum annuum Vegetables
BXGF00831 Orange bell pepper Capsicum annuum Vegetables
BXGF00832 Red bell pepper Capsicum annuum Vegetables
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease