Showing entry for Ubiquitin-conjugating enzyme E2 D1



                       
General Target Information
BXGT IdBXGT010875
Protein NameUbiquitin-conjugating enzyme E2 D1
Uniport IdP51668
GeneUBE2D1
Gene Id7321
DomainUQ_con
Pfam PF00179  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04141 Protein processing in endoplasmic reticulum
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05131 Shigellosis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0031145 anaphase-promoting complex-dependent catabolic process
Biological Process GO:0030509 BMP signaling pathway
Biological Process GO:0002756 MyD88-independent toll-like receptor signaling pathway
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:1902916 positive regulation of protein polyubiquitination
Biological Process GO:0031398 positive regulation of protein ubiquitination
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0070936 protein K48-linked ubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0006625 protein targeting to peroxisome
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:1901990 regulation of mitotic cell cycle phase transition
Biological Process GO:0035666 TRIF-dependent toll-like receptor signaling pathway
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
molecular function GO:0005524 ATP binding
molecular function GO:0061631 ubiquitin conjugating enzyme activity
molecular function GO:0031625 ubiquitin protein ligase binding
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0032991 protein-containing complex
cellular component GO:0000151 ubiquitin ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-1234174 Cellular response to hypoxia
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-1280218 Adaptive Immune System
R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-162582 Signal Transduction
R-HSA-1640170 Cell Cycle
R-HSA-1643685 Disease
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-168249 Innate Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168256 Immune System
R-HSA-168898 Toll-like Receptor Cascades
R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta
R-HSA-170834 Signaling by TGF-beta Receptor Complex
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176412 Phosphorylation of the APC/C
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
R-HSA-201451 Signaling by BMP
R-HSA-202403 TCR signaling
R-HSA-202424 Downstream TCR signaling
R-HSA-212436 Generic Transcription Pathway
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
R-HSA-2262752 Cellular responses to stress
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559583 Cellular Senescence
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-392499 Metabolism of proteins
R-HSA-453276 Regulation of mitotic cell cycle
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-5688426 Deubiquitination
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-597592 Post-translational protein modification
R-HSA-68882 Mitotic Anaphase
R-HSA-68886 M Phase
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-69052 Switching of origins to a post-replicative state
R-HSA-69239 Synthesis of DNA
R-HSA-69242 S Phase
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-69306 DNA Replication
R-HSA-69618 Mitotic Spindle Checkpoint
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8852135 Protein ubiquitination
R-HSA-8853884 Transcriptional Regulation by VENTX
R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins
R-HSA-8951664 Neddylation
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-9006936 Signaling by TGFB family members
R-HSA-9033241 Peroxisomal protein import
R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling
R-HSA-937041 IKK complex recruitment mediated by RIP1
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-9609507 Protein localization
R-HSA-9675126 Diseases of mitotic cell cycle
R-HSA-9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects
R-HSA-9687139 Aberrant regulation of mitotic cell cycle due to RB1 defects
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0018922 BXGD001247 hemangiopericytoma Neoplasms
C0018995 BXGD001265 Hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019159 BXGD001294 Hepatitis A Digestive System Diseases; Infections
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0206643 BXGD004208 Neoplasms, Fibrous Tissue Neoplasms
C0240066 BXGD005016 Iron deficiency Nutritional and Metabolic Diseases
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0334608 BXGD007136 Angiomatous Meningioma Neoplasms; Nervous System Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0392514 BXGD008051 Hereditary hemochromatosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0549423 BXGD009380 Obstructive Hydrocephalus Nervous System Diseases
C0940937 BXGD011490 precancerous lesions
C1266119 BXGD011964 Solitary fibrous tumor Neoplasms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1334699 BXGD012731 Mesenchymal Cell Neoplasm Neoplasms
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3469186 BXGD018909 HEMOCHROMATOSIS, TYPE 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein