Showing entry for Integrin alpha-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011150
Protein NameIntegrin alpha-1
Uniport IdP56199
GeneITGA1
Gene Id3672
DomainFG-GAP; Integrin_alpha2; VWA
Pfam PF01839   PF08441   PF00092  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04512 ECM-receptor interaction
5. Organismal Systems 5.1 Immune system hsa04640 Hematopoietic cell lineage
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0000187 activation of MAPK activity
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0045123 cellular extravasation
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0006936 muscle contraction
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0030593 neutrophil chemotaxis
Biological Process GO:0043525 positive regulation of neuron apoptotic process
Biological Process GO:0032516 positive regulation of phosphoprotein phosphatase activity
Biological Process GO:0042311 vasodilation
molecular function GO:0005518 collagen binding
molecular function GO:0098639 collagen binding involved in cell-matrix adhesion
molecular function GO:0046872 metal ion binding
molecular function GO:0019903 protein phosphatase binding
molecular function GO:0005102 signaling receptor binding
cellular component GO:0001669 acrosomal vesicle
cellular component GO:0045178 basal part of cell
cellular component GO:0009986 cell surface
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0005925 focal adhesion
cellular component GO:0034665 integrin alpha1-beta1 complex
cellular component GO:0008305 integrin complex
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0043005 neuron projection
cellular component GO:0043204 perikaryon
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109582 Hemostasis
R-HSA-1266738 Developmental Biology
R-HSA-1474244 Extracellular matrix organization
R-HSA-1474244 Extracellular matrix organization
R-HSA-216083 Integrin cell surface interactions
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000157 Laminin interactions
R-HSA-373755 Semaphorin interactions
R-HSA-373760 L1CAM interactions
R-HSA-397014 Muscle contraction
R-HSA-416700 Other semaphorin interactions
R-HSA-422475 Axon guidance
R-HSA-445355 Smooth Muscle Contraction
R-HSA-447041 CHL1 interactions
R-HSA-75892 Platelet Adhesion to exposed collagen
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003872 BXGD000235 Arthritis, Psoriatic Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0011195 BXGD000702 Dejerine-Sottas Disease (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0016529 BXGD001068 Forced expiratory volume function
C0017639 BXGD001133 Gliosis Pathological Conditions, Signs and Symptoms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0021368 BXGD001502 Inflammation Pathological Conditions, Signs and Symptoms
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029456 BXGD002157 Osteoporosis Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0031538 BXGD002305 Phimosis Male Urogenital Diseases
C0035227 BXGD002514 Respiratory Function Tests
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042769 BXGD002999 Virus Diseases Infections
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0206161 BXGD004167 Reticulocyte count (procedure)
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0275518 BXGD006375 Acute infectious disease Pathological Conditions, Signs and Symptoms; Infections
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0549493 BXGD009385 Alveolitis Skin and Connective Tissue Diseases; Respiratory Tract Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1278049 BXGD012114 Serum gamma-glutamyl transferase measurement
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1518922 BXGD013229 peak expiratory flow (procedure)
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1848296 BXGD014918 DOSAGE-SENSITIVE SEX REVERSAL Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2062441 BXGD016897 Influenza A
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3887640 BXGD019908 Astrocytosis Pathological Conditions, Signs and Symptoms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein