Showing entry for Primary biliary cirrhosis


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD000527
Disease NamePrimary biliary cirrhosis
Disease CUI IdC0008312
MeSH Codes C23   C06  
Disease Class NamePathological Conditions, Signs and Symptoms; Digestive System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0025031  
Human Phenotype Ontology TermAbnormality of the digestive system
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00330 BXGT003910 Pyruvate dehydrogenase protein X component, mitochondrial 8050 reviewed Enzyme
O00462 BXGT003925 Beta-mannosidase 4126 reviewed Enzyme
O14788 BXGT004100 Tumor necrosis factor ligand superfamily member 11 8600 reviewed Signaling
O15111 BXGT004126 Inhibitor of nuclear factor kappa-B kinase subunit alpha 1147 reviewed Kinase
O15245 BXGT004141 Solute carrier family 22 member 1 6580 reviewed Transporter
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 8714 reviewed Transporter
O15439 BXGT004169 Multidrug resistance-associated protein 4 10257 reviewed Transporter
O15455 BXGT004171 Toll-like receptor 3 7098 reviewed Receptor
O43278 BXGT004581 Kunitz-type protease inhibitor 1 6692 reviewed
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O60760 BXGT004899 Hematopoietic prostaglandin D synthase 27306 reviewed
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 8856 reviewed Nuclear receptor
O75676 BXGT005144 Ribosomal protein S6 kinase alpha-4 8986 reviewed Kinase
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase 8654 reviewed
O94813 BXGT005337 Slit homolog 2 protein 9353 reviewed
O95150 BXGT005351 Tumor necrosis factor ligand superfamily member 15 9966 reviewed Signaling
O95255 BXGT005363 Multidrug resistance-associated protein 6 368 reviewed Transporter
O95342 BXGT005373 Bile salt export pump 8647 reviewed Transporter
O95477 BXGT005383 Phospholipid-transporting ATPase ABCA1 19 reviewed Transporter
O95631 BXGT005387 Netrin-1 9423 reviewed Enzyme modulator
O95750 BXGT005395 Fibroblast growth factor 19 9965 reviewed Signaling
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01009 BXGT005714 Alpha-1-antitrypsin 5265 reviewed Enzyme modulator
P01019 BXGT005717 Angiotensinogen 183 reviewed Enzyme modulator
P01111 BXGT005731 GTPase NRas 4893 reviewed Enzyme modulator
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01583 BXGT005771 Interleukin-1 alpha 3552 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01589 BXGT005773 Interleukin-2 receptor subunit alpha 3559 reviewed Receptor
P01889 BXGT005809 HLA class I histocompatibility antigen, B-7 alpha chain 3106 reviewed
P01903 BXGT005814 HLA class II histocompatibility antigen, DR alpha chain 3122 reviewed Immune response
P01909 BXGT005815 HLA class II histocompatibility antigen, DQ alpha 1 chain 3117 reviewed Immune response
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P01920 BXGT005817 HLA class II histocompatibility antigen, DQ beta 1 chain 3119 reviewed Immune response
P02452 BXGT005878 Collagen alpha-1(I) chain 1277 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02750 BXGT005942 Leucine-rich alpha-2-glycoprotein 116844 reviewed
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04440 BXGT006216 HLA class II histocompatibility antigen, DP beta 1 chain 3115 reviewed Immune response
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05107 BXGT006316 Integrin beta-2 3689 reviewed Receptor
P05187 BXGT006339 Alkaline phosphatase, placental type 250 reviewed Enzyme
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05362 BXGT006350 Intercellular adhesion molecule 1 3383 reviewed
P05771 BXGT006384 Protein kinase C beta type 5579 reviewed Kinase
P06133 BXGT006414 UDP-glucuronosyltransferase 2B4 7363 reviewed
P06730 BXGT006487 Eukaryotic translation initiation factor 4E 1977 reviewed Nucleic acid binding
P06756 BXGT006499 Integrin alpha-V 3685 reviewed
P07355 BXGT006609 Annexin A2 302 reviewed
P08183 BXGT006741 ATP-dependent translocase ABCB1 5243 reviewed Transporter
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P08254 BXGT006758 Stromelysin-1 4314 reviewed Enzyme
P08648 BXGT006804 Integrin alpha-5 3678 reviewed
P08684 BXGT006812 Cytochrome P450 3A4 1576 reviewed Enzyme
P08686 BXGT006813 Steroid 21-hydroxylase 1589 reviewed
P08833 BXGT006827 Insulin-like growth factor-binding protein 1 3484 reviewed Enzyme modulator
P09429 BXGT006889 High mobility group protein B1 3146 reviewed Nucleic acid binding
P09488 BXGT006899 Glutathione S-transferase Mu 1 2944 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P0C0L4 BXGT007387 Complement C4-A 721 reviewed
P0C0L5 BXGT007388 Complement C4-B 721 reviewed
P10144 BXGT007541 Granzyme B 3002 reviewed Enzyme
P10145 BXGT007542 Interleukin-8 3576 reviewed Signaling
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P10747 BXGT007609 T-cell-specific surface glycoprotein CD28 940 reviewed
P10809 BXGT007617 60 kDa heat shock protein, mitochondrial 3329 reviewed
P11226 BXGT007675 Mannose-binding protein C 4153 reviewed Receptor
P11274 BXGT007681 Breakpoint cluster region protein 613 reviewed Enzyme modulator
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P11912 BXGT007758 B-cell antigen receptor complex-associated protein alpha chain 973 reviewed Receptor
P12821 BXGT007849 Angiotensin-converting enzyme 1636 reviewed Enzyme
P13501 BXGT007917 C-C motif chemokine 5 6352 reviewed Signaling
P13569 BXGT007923 Cystic fibrosis transmembrane conductance regulator 1080 reviewed Ion channel
P14174 BXGT007991 Macrophage migration inhibitory factor 4282 reviewed
P14210 BXGT007994 Hepatocyte growth factor 3082 reviewed Enzyme
P14780 BXGT008053 Matrix metalloproteinase-9 4318 reviewed Enzyme
P15559 BXGT008139 NAD(P)H dehydrogenase [quinone] 1 1728 reviewed
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P15813 BXGT008158 Antigen-presenting glycoprotein CD1d 912 reviewed
P16278 BXGT008213 Beta-galactosidase 2720 reviewed Enzyme
P16410 BXGT008224 Cytotoxic T-lymphocyte protein 4 1493 reviewed
P16442 BXGT008227 Histo-blood group ABO system transferase 28 reviewed Enzyme
P16871 BXGT008269 Interleukin-7 receptor subunit alpha 3575 reviewed Receptor
P17931 BXGT008356 Galectin-3 3958 reviewed Signaling
P19320 BXGT008470 Vascular cell adhesion protein 1 7412 reviewed
P19367 BXGT008476 Hexokinase-1 3098 reviewed Kinase
P19438 BXGT008480 Tumor necrosis factor receptor superfamily member 1A 7132 reviewed
P19440 BXGT008481 Glutathione hydrolase 1 proenzyme 2678 reviewed Enzyme
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit 4790 reviewed Transcription factor
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 1131 reviewed G-protein coupled receptor
P20701 BXGT008591 Integrin alpha-L 3683 reviewed
P21439 BXGT008649 Phosphatidylcholine translocator ABCB4 5244 reviewed Transporter
P21980 BXGT008715 Protein-glutamine gamma-glutamyltransferase 2 7052 reviewed Enzyme
P22087 BXGT008729 rRNA 2'-O-methyltransferase fibrillarin 2091 reviewed Enzyme
P22680 BXGT008794 Cholesterol 7-alpha-monooxygenase 1581 reviewed Enzyme
P22749 BXGT008803 Granulysin 10578 reviewed
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 6198 reviewed Kinase
P24298 BXGT008960 Alanine aminotransferase 1 2875 reviewed Enzyme
P24855 BXGT008998 Deoxyribonuclease-1 1773 reviewed
P25789 BXGT009071 Proteasome subunit alpha type-4 5685 reviewed
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P26196 BXGT009089 Probable ATP-dependent RNA helicase DDX6 1656 reviewed
P26358 BXGT009104 DNA (cytosine-5)-methyltransferase 1 1786 reviewed Epigenetic regulator
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P28161 BXGT009234 Glutathione S-transferase Mu 2 2946 reviewed
P28300 BXGT009243 Protein-lysine 6-oxidase 4015 reviewed
P29017 BXGT009305 T-cell surface glycoprotein CD1c 911 reviewed
P29460 BXGT009348 Interleukin-12 subunit beta 3593 reviewed Signaling
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P29508 BXGT009358 Serpin B3 6317 reviewed Enzyme modulator
P29597 BXGT009367 Non-receptor tyrosine-protein kinase TYK2 7297 reviewed Kinase
P29965 BXGT009388 CD40 ligand 959 reviewed Signaling
P32004 BXGT009594 Neural cell adhesion molecule L1 3897 reviewed
P32302 BXGT009619 C-X-C chemokine receptor type 5 643 reviewed G-protein coupled receptor
P33527 BXGT009728 Multidrug resistance-associated protein 1 4363 reviewed Transporter
P33681 BXGT009739 T-lymphocyte activation antigen CD80 941 reviewed
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35372 BXGT009823 Mu-type opioid receptor 4988 reviewed G-protein coupled receptor
P35610 BXGT009855 Sterol O-acyltransferase 1 6646 reviewed Enzyme
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P38936 BXGT010074 Cyclin-dependent kinase inhibitor 1 1026 reviewed
P39086 BXGT010093 Glutamate receptor ionotropic, kainate 1 2897 reviewed Ion channel
P40763 BXGT010202 Signal transducer and activator of transcription 3 6774 reviewed Nucleic acid binding
P41235 BXGT010241 Hepatocyte nuclear factor 4-alpha 3172 reviewed Nuclear receptor
P41273 BXGT010251 Tumor necrosis factor ligand superfamily member 9 8744 reviewed
P42224 BXGT010286 Signal transducer and activator of transcription 1-alpha/beta 6772 reviewed Nucleic acid binding
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P45452 BXGT010462 Collagenase 3 4322 reviewed Enzyme
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P50440 BXGT010798 Glycine amidinotransferase, mitochondrial 2628 reviewed
P50591 BXGT010814 Tumor necrosis factor ligand superfamily member 10 8743 reviewed Signaling
P51580 BXGT010864 Thiopurine S-methyltransferase 7172 reviewed
P51681 BXGT010878 C-C chemokine receptor type 5 1234 reviewed G-protein coupled receptor
P51692 BXGT010885 Signal transducer and activator of transcription 5B 6777 reviewed Nucleic acid binding
P55087 BXGT011105 Aquaporin-4 361 reviewed Ion channel
P56199 BXGT011150 Integrin alpha-1 3672 reviewed
P60022 BXGT011285 Beta-defensin 1 1672 reviewed
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P78556 BXGT011849 C-C motif chemokine 20 6364 reviewed Signaling
P80511 BXGT011914 Protein S100-A12 6283 reviewed Calcium-binding protein
P81172 BXGT011935 Hepcidin 57817 reviewed
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 4088 reviewed Transcription factor
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q06520 BXGT012880 Bile salt sulfotransferase 6822 reviewed
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q07954 BXGT012950 Prolow-density lipoprotein receptor-related protein 1 4035 reviewed
Q08345 BXGT012982 Epithelial discoidin domain-containing receptor 1 780 reviewed Kinase
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q12908 BXGT013278 Ileal sodium/bile acid cotransporter 6555 reviewed Transporter
Q13137 BXGT013316 Calcium-binding and coiled-coil domain-containing protein 2 10241 reviewed
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13478 BXGT013362 Interleukin-18 receptor 1 8809 reviewed Receptor
Q13501 BXGT013365 Sequestosome-1 8878 reviewed
Q14116 BXGT013442 Interleukin-18 3606 reviewed
Q14118 BXGT013444 Dystroglycan 1605 reviewed Receptor
Q14145 BXGT013448 Kelch-like ECH-associated protein 1 9817 reviewed
Q14392 BXGT013465 Transforming growth factor beta activator LRRC32 2615 reviewed Receptor
Q14624 BXGT013491 Inter-alpha-trypsin inhibitor heavy chain H4 3700 reviewed Enzyme modulator
Q14973 BXGT013515 Sodium/bile acid cotransporter 6554 reviewed Transporter
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 9970 reviewed Nuclear receptor
Q15116 BXGT013539 Programmed cell death protein 1 5133 reviewed
Q15796 BXGT013599 Mothers against decapentaplegic homolog 2 4087 reviewed Transcription factor
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 4780 reviewed Enzyme
Q16539 BXGT013634 Mitogen-activated protein kinase 14 1432 reviewed Kinase
Q16654 BXGT013650 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 5166 reviewed Kinase
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha 3091 reviewed Transcription factor
Q16832 BXGT013678 Discoidin domain-containing receptor 2 4921 reviewed Kinase
Q16874 BXGT013685 Cytochrome P450 21-hydroxylase 1589 unreviewed
Q53G59 BXGT015011 Kelch-like protein 12 59349 reviewed
Q5Y7D3 BXGT015912 HLA class II histocompatibility antigen DQ beta chain 3119 unreviewed
Q6P589 BXGT016452 Tumor necrosis factor alpha-induced protein 8-like protein 2 79626 reviewed
Q6V1X1 BXGT016574 Dipeptidyl peptidase 8 54878 reviewed Enzyme
Q7L266 BXGT016993 Isoaspartyl peptidase/L-asparaginase 80150 reviewed Enzyme
Q7Z3B3 BXGT017249 KAT8 regulatory NSL complex subunit 1 284058 reviewed
Q7Z7D3 BXGT017262 V-set domain-containing T-cell activation inhibitor 1 79679 reviewed Enzyme modulator
Q86UW1 BXGT017613 Organic solute transporter subunit alpha 200931 reviewed Transporter
Q8IXH7 BXGT018359 Negative elongation factor C/D 51497 reviewed
Q8NBL1 BXGT018539 Protein O-glucosyltransferase 1 56983 reviewed
Q8TAX9 BXGT018788 Gasdermin-B 55876 reviewed
Q8TDU6 BXGT018814 G-protein coupled bile acid receptor 1 151306 reviewed G-protein coupled receptor
Q8WWA0 BXGT018999 Intelectin-1 55600 reviewed
Q8WWM9 BXGT019001 Cytoglobin 114757 reviewed
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 1244 reviewed Transporter
Q93088 BXGT019458 Betaine--homocysteine S-methyltransferase 1 635 reviewed
Q96AZ6 BXGT019621 Interferon-stimulated gene 20 kDa protein 3669 reviewed
Q96E93 BXGT019645 Killer cell lectin-like receptor subfamily G member 1 10219 reviewed
Q96QV1 BXGT019722 Hedgehog-interacting protein 64399 reviewed
Q96RI1 BXGT019727 Bile acid receptor 9971 reviewed Nuclear receptor
Q99467 BXGT019923 CD180 antigen 4064 reviewed Receptor
Q99558 BXGT019934 Mitogen-activated protein kinase kinase kinase 14 9020 reviewed Kinase
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q99828 BXGT019967 Calcium and integrin-binding protein 1 10519 reviewed
Q99836 BXGT019970 Myeloid differentiation primary response protein MyD88 4615 reviewed Enzyme modulator
Q9BYF1 BXGT020186 Angiotensin-converting enzyme 2 59272 reviewed Enzyme
Q9BZS1 BXGT020203 Forkhead box protein P3 50943 reviewed
Q9H0A0 BXGT020434 RNA cytidine acetyltransferase 55226 reviewed
Q9HBE5 BXGT020518 Interleukin-21 receptor 50615 reviewed Receptor
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 28234 reviewed Transporter
Q9NR96 BXGT021181 Toll-like receptor 9 54106 reviewed
Q9NWB1 BXGT021231 RNA binding protein fox-1 homolog 1 54715 reviewed Nucleic acid binding
Q9NYB5 BXGT021255 Solute carrier organic anion transporter family member 1C1 53919 reviewed Transporter
Q9NYV4 BXGT021262 Cyclin-dependent kinase 12 51755 reviewed Kinase
Q9NZQ7 BXGT021281 Programmed cell death 1 ligand 1 29126 reviewed Receptor
Q9P2W7 BXGT021306 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 27087 reviewed Enzyme
Q9UJ71 BXGT021725 C-type lectin domain family 4 member K 50489 reviewed Receptor
Q9UKV0 BXGT021750 Histone deacetylase 9 9734 reviewed Epigenetic regulator
Q9UKV8 BXGT021752 Protein argonaute-2 27161 reviewed
Q9UNQ0 BXGT021792 ATP-binding cassette sub-family G member 2 9429 reviewed Transporter
Q9Y275 BXGT022223 Tumor necrosis factor ligand superfamily member 13B 10673 reviewed
Q9Y2R2 BXGT022243 Tyrosine-protein phosphatase non-receptor type 22 26191 reviewed
Q9Y4K0 BXGT022280 Lysyl oxidase homolog 2 4017 reviewed
Q9Y572 BXGT022289 Receptor-interacting serine/threonine-protein kinase 3 11035 reviewed Kinase
Q9Y5L0 BXGT022296 Transportin-3 23534 reviewed Transporter
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 10599 reviewed Transporter
P04439 BXGT022649 HLA class I histocompatibility antigen, A-3 alpha chain 3105 reviewed
P52824 BXGT022672 Diacylglycerol kinase theta 1609 reviewed Kinase
P20036 BXGT022764 HLA class II histocompatibility antigen, DP alpha 1 chain 3113 reviewed Immune response
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
Q5JS54 BXGT023468 Proteasome assembly chaperone 4 389362 reviewed
P56703 BXGT023722 Proto-oncogene Wnt-3 7473 reviewed Signaling
P07954 BXGT023939 Fumarate hydratase, mitochondrial 2271 reviewed Enzyme
P23497 BXGT024062 Nuclear autoantigen Sp-100 6672 reviewed
O60232 BXGT024169 Protein ZNRD2 10534 reviewed
P29590 BXGT024350 Protein PML 5371 reviewed
P23511 BXGT025343 Nuclear transcription factor Y subunit alpha 4800 reviewed Nucleic acid binding
P19474 BXGT025520 E3 ubiquitin-protein ligase TRIM21 6737 reviewed
Q9UGM3 BXGT025543 Deleted in malignant brain tumors 1 protein 1755 reviewed Enzyme
P11836 BXGT025994 B-lymphocyte antigen CD20 931 reviewed Receptor
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease