Showing entry for Neutrophil defensin 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011272
Protein NameNeutrophil defensin 1
Uniport IdP59665
GeneDEFA1
Gene Id1667;728358
DomainDefensin_1; Defensin_propep
Pfam PF00323   PF00879  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
6. Human Diseases 6.8 Infectious diseases: Bacterial hsa05150 Staphylococcus aureus infection
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019731 antibacterial humoral response
Biological Process GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process GO:0019730 antimicrobial humoral response
Biological Process GO:0071222 cellular response to lipopolysaccharide
Biological Process GO:0006935 chemotaxis
Biological Process GO:0050832 defense response to fungus
Biological Process GO:0050829 defense response to Gram-negative bacterium
Biological Process GO:0050830 defense response to Gram-positive bacterium
Biological Process GO:0042832 defense response to protozoan
Biological Process GO:0051607 defense response to virus
Biological Process GO:0006955 immune response
Biological Process GO:0002227 innate immune response in mucosa
Biological Process GO:0030520 intracellular estrogen receptor signaling pathway
Biological Process GO:0051873 killing by host of symbiont cells
Biological Process GO:0031640 killing of cells of other organism
Biological Process GO:0051673 membrane disruption in other organism
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0044657 pore formation in membrane of other organism during symbiotic interaction
Biological Process GO:0010818 T cell chemotaxis
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0062023 collagen-containing extracellular matrix
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005615 extracellular space
cellular component GO:0005796 Golgi lumen
Reactome
Pathway Id Pathway Name
R-HSA-1461973 Defensins
R-HSA-1462054 Alpha-defensins
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001342 BXGD000042 Acute periodontitis Stomatognathic Diseases
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001429 BXGD000053 Adenolymphoma Neoplasms
C0001486 BXGD000056 Adenovirus Infections Infections
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009663 BXGD000618 Condylomata Acuminata Infections; Skin and Connective Tissue Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0023474 BXGD001662 Leukemia, Myeloid, Chronic-Phase Neoplasms; Hemic and Lymphatic Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0026277 BXGD001899 Mixed Salivary Gland Tumor Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0030499 BXGD002232 Parasitic Diseases Infections
C0031090 BXGD002280 Periodontal Diseases Stomatognathic Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0031106 BXGD002283 Aggressive Periodontitis Stomatognathic Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0041696 BXGD002932 Unipolar Depression Mental Disorders
C0041912 BXGD002937 Upper Respiratory Infections Infections; Respiratory Tract Diseases
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0581381 BXGD009567 Recurrent upper respiratory tract infection Infections; Respiratory Tract Diseases
C0851887 BXGD010930 Adenoviral infections
C0858762 BXGD011190 Neuro-Behcet disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1608408 BXGD013434 Malignant transformation
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1843013 BXGD014549 Alzheimer disease, familial, type 3 Nervous System Diseases; Mental Disorders
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0003705 Chloride 35.45
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein