Showing entry for Alzheimer disease, familial, type 3


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD014549
Disease NameAlzheimer disease, familial, type 3
Disease CUI IdC1843013
MeSH Codes C10   F03  
Disease Class NameNervous System Diseases; Mental Disorders
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id   
Human Phenotype Ontology Term
Disease Ontology Id DOID:630   DOID:7  
Disease Ontology Class Namegenetic disease; disease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00206 BXGT003894 Toll-like receptor 4 7099 reviewed
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O14646 BXGT004079 Chromodomain-helicase-DNA-binding protein 1 1105 reviewed
O14672 BXGT004081 Disintegrin and metalloproteinase domain-containing protein 10 102 reviewed
O43612 BXGT004605 Orexin 3060 reviewed
O60603 BXGT004887 Toll-like receptor 2 7097 reviewed
O60858 BXGT004903 E3 ubiquitin-protein ligase TRIM13 10206 reviewed
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
O95477 BXGT005383 Phospholipid-transporting ATPase ABCA1 19 reviewed Transporter
P00441 BXGT005540 Superoxide dismutase [Cu-Zn] 6647 reviewed Enzyme
P01137 BXGT005737 Transforming growth factor beta-1 proprotein 7040 reviewed Signaling
P01308 BXGT005749 Insulin 3630 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01579 BXGT005770 Interferon gamma 3458 reviewed
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P01920 BXGT005817 HLA class II histocompatibility antigen, DQ beta 1 chain 3119 reviewed Immune response
P02461 BXGT005880 Collagen alpha-1(III) chain 1281 reviewed
P02649 BXGT005909 Apolipoprotein E 348 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02766 BXGT005953 Transthyretin 7276 reviewed Transporter
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P04150 BXGT006154 Glucocorticoid receptor 2908 reviewed Nuclear receptor
P04155 BXGT006155 Trefoil factor 1 7031 reviewed Signaling
P04637 BXGT006243 Cellular tumor antigen p53 7157 reviewed Transcription factor
P05067 BXGT006306 Amyloid-beta precursor protein 351 reviewed Enzyme modulator
P05090 BXGT006311 Apolipoprotein D 347 reviewed
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06276 BXGT006430 Cholinesterase 590 reviewed
P06731 BXGT006488 Carcinoembryonic antigen-related cell adhesion molecule 5 1048 reviewed
P06748 BXGT006497 Nucleophosmin 4869 reviewed Chaperone
P07288 BXGT006591 Prostate-specific antigen 354 reviewed Enzyme
P08047 BXGT006720 Transcription factor Sp1 6667 reviewed Nucleic acid binding
P08581 BXGT006794 Hepatocyte growth factor receptor 4233 reviewed Kinase
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P0DMV8 BXGT007509 Heat shock 70 kDa protein 1A 3304 reviewed
P0DMV9 BXGT007510 Heat shock 70 kDa protein 1B 3304 reviewed
P10415 BXGT007567 Apoptosis regulator Bcl-2 596 reviewed Signaling
P10635 BXGT007595 Cytochrome P450 2D6 1565 reviewed
P10636 BXGT007596 Microtubule-associated protein tau 4137 reviewed
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P10909 BXGT007630 Clusterin 1191 reviewed
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P12318 BXGT007799 Low affinity immunoglobulin gamma Fc region receptor II-a 2212 reviewed Cell adhesion
P14416 BXGT008011 D(2) dopamine receptor 1813 reviewed G-protein coupled receptor
P14735 BXGT008042 Insulin-degrading enzyme 3416 reviewed Enzyme
P15529 BXGT008134 Membrane cofactor protein 4179 reviewed
P16671 BXGT008255 Platelet glycoprotein 4 948 reviewed Receptor
P17516 BXGT008313 Aldo-keto reductase family 1 member C4 1109 reviewed Enzyme
P19320 BXGT008470 Vascular cell adhesion protein 1 7412 reviewed
P19440 BXGT008481 Glutathione hydrolase 1 proenzyme 2678 reviewed Enzyme
P20930 BXGT008616 Filaggrin 2312 reviewed Cellular structure
P21579 BXGT008665 Synaptotagmin-1 6857 reviewed Transporter
P21917 BXGT008707 D(4) dopamine receptor 1815 reviewed G-protein coupled receptor
P22303 BXGT008751 Acetylcholinesterase 43 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P24298 BXGT008960 Alanine aminotransferase 1 2875 reviewed Enzyme
P27169 BXGT009161 Serum paraoxonase/arylesterase 1 5444 reviewed
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase 328 reviewed
P28223 BXGT009239 5-hydroxytryptamine receptor 2A 3356 reviewed G-protein coupled receptor
P28329 BXGT009251 Choline O-acetyltransferase 1103 reviewed Enzyme
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P34932 BXGT009772 Heat shock 70 kDa protein 4 3308 reviewed
P35354 BXGT009816 Prostaglandin G/H synthase 2 5743 reviewed Enzyme
P35916 BXGT009881 Vascular endothelial growth factor receptor 3 2324 reviewed Kinase
P36222 BXGT009914 Chitinase-3-like protein 1 1116 reviewed
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P38571 BXGT010054 Lysosomal acid lipase/cholesteryl ester hydrolase 3988 reviewed Enzyme
P40933 BXGT010209 Interleukin-15 3600 reviewed
P41180 BXGT010230 Extracellular calcium-sensing receptor 846 reviewed G-protein coupled receptor
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P43004 BXGT010348 Excitatory amino acid transporter 2 6506 reviewed Transporter
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P49810 BXGT010747 Presenilin-2 5664 reviewed Enzyme
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
P56192 BXGT011149 Methionine--tRNA ligase, cytoplasmic 4141 reviewed
P56817 BXGT011200 Beta-secretase 1 23621 reviewed Enzyme
P59665 BXGT011272 Neutrophil defensin 1 728358 reviewed
P60568 BXGT011315 Interleukin-2 3558 reviewed
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P62834 BXGT011464 Ras-related protein Rap-1A 5906 reviewed Enzyme modulator
P63244 BXGT011510 Receptor of activated protein C kinase 1 10399 reviewed
P78310 BXGT011830 Coxsackievirus and adenovirus receptor 1525 reviewed
P78344 BXGT011835 Eukaryotic translation initiation factor 4 gamma 2 1982 reviewed Nucleic acid binding
P78556 BXGT011849 C-C motif chemokine 20 6364 reviewed Signaling
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q06481 BXGT012878 Amyloid-like protein 2 334 reviewed Enzyme modulator
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13418 BXGT013351 Integrin-linked protein kinase 3611 reviewed Kinase
Q14994 BXGT013519 Nuclear receptor subfamily 1 group I member 3 9970 reviewed Nuclear receptor
Q15109 BXGT013537 Advanced glycosylation end product-specific receptor 177 reviewed Receptor
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q15910 BXGT013612 Histone-lysine N-methyltransferase EZH2 2146 reviewed Epigenetic regulator
Q16568 BXGT013640 Cocaine- and amphetamine-regulated transcript protein 9607 reviewed
Q5S007 BXGT015650 Leucine-rich repeat serine/threonine-protein kinase 2 120892 reviewed Kinase
Q5VWK5 BXGT015891 Interleukin-23 receptor 149233 reviewed Signaling
Q5Y7D3 BXGT015912 HLA class II histocompatibility antigen DQ beta chain 3119 unreviewed
Q76LX8 BXGT016870 A disintegrin and metalloproteinase with thrombospondin motifs 13 11093 reviewed Enzyme
Q86YI8 BXGT017634 PHD finger protein 13 148479 reviewed Epigenetic regulator
Q8NFD2 BXGT018559 Ankyrin repeat and protein kinase domain-containing protein 1 255239 reviewed Kinase
Q8TCG1 BXGT018797 Protein CIP2A 57650 reviewed
Q92743 BXGT019368 Serine protease HTRA1 5654 reviewed Enzyme
Q92876 BXGT019388 Kallikrein-6 5653 reviewed Enzyme
Q99523 BXGT019929 Sortilin 6272 reviewed Transporter
Q99757 BXGT019959 Thioredoxin, mitochondrial 25828 reviewed Enzyme
Q9BXM7 BXGT020172 Serine/threonine-protein kinase PINK1, mitochondrial 65018 reviewed Kinase
Q9GZX6 BXGT020428 Interleukin-22 50616 reviewed
Q9H4A3 BXGT020473 Serine/threonine-protein kinase WNK1 65125 reviewed Kinase
Q9P2R7 BXGT021304 Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial 8803 reviewed Enzyme
Q9UJ41 BXGT021723 Rab5 GDP/GTP exchange factor 27342 reviewed Enzyme modulator
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
Q9UBP0 BXGT023601 Spastin 6683 reviewed Cellular structure
Q9BQQ3 BXGT024065 Golgi reassembly-stacking protein 1 64689 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease