Showing entry for AP-2 complex subunit beta


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011484
Protein NameAP-2 complex subunit beta
Uniport IdP63010
GeneAP2B1
Gene Id163
DomainAdaptin_N; Alpha_adaptinC2; B2-adapt-app_C
Pfam PF01602   PF02883   PF09066  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
4. Cellular Processes 4.1 Transport and catabolism hsa04144 Endocytosis
5. Organismal Systems 5.6 Nervous system hsa04721 Synaptic vesicle cycle
5. Organismal Systems 5.5 Excretory system hsa04961 Endocrine and other factor-regulated calcium reabsorption
6. Human Diseases 6.4 Neurodegenerative diseases hsa05016 Huntington disease
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Biological Process GO:0035904 aorta development
Biological Process GO:0048268 clathrin coat assembly
Biological Process GO:0072583 clathrin-dependent endocytosis
Biological Process GO:0060976 coronary vasculature development
Biological Process GO:0048013 ephrin receptor signaling pathway
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0001822 kidney development
Biological Process GO:0034383 low-density lipoprotein particle clearance
Biological Process GO:0032802 low-density lipoprotein particle receptor catabolic process
Biological Process GO:0061024 membrane organization
Biological Process GO:1901215 negative regulation of neuron death
Biological Process GO:0099590 neurotransmitter receptor internalization
Biological Process GO:0045807 positive regulation of endocytosis
Biological Process GO:1905477 positive regulation of protein localization to membrane
Biological Process GO:0050690 regulation of defense response to virus by virus
Biological Process GO:0003281 ventricular septum development
Biological Process GO:0016192 vesicle-mediated transport
Biological Process GO:0060071 Wnt signaling pathway, planar cell polarity pathway
molecular function GO:0030276 clathrin binding
molecular function GO:0044877 protein-containing complex binding
molecular function GO:0005048 signal sequence binding
cellular component GO:0030122 AP-2 adaptor complex
cellular component GO:0030131 clathrin adaptor complex
cellular component GO:0045334 clathrin-coated endocytic vesicle
cellular component GO:0030669 clathrin-coated endocytic vesicle membrane
cellular component GO:0005829 cytosol
cellular component GO:0030666 endocytic vesicle membrane
cellular component GO:0036020 endolysosome membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0098794 postsynapse
Reactome
Pathway Id Pathway Name
R-HSA-1266738 Developmental Biology
R-HSA-1266738 Developmental Biology
R-HSA-1280218 Adaptive Immune System
R-HSA-162582 Signal Transduction
R-HSA-162582 Signal Transduction
R-HSA-162906 HIV Infection
R-HSA-162909 Host Interactions of HIV factors
R-HSA-1643685 Disease
R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis
R-HSA-166520 Signaling by NTRKs
R-HSA-166520 Signaling by NTRKs
R-HSA-167590 Nef Mediated CD4 Down-regulation
R-HSA-168256 Immune System
R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-177504 Retrograde neurotrophin signalling
R-HSA-182218 Nef Mediated CD8 Down-regulation
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-195721 Signaling by WNT
R-HSA-199991 Membrane Trafficking
R-HSA-2132295 MHC class II antigen presentation
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-373760 L1CAM interactions
R-HSA-373760 L1CAM interactions
R-HSA-382551 Transport of small molecules
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-4086400 PCP/CE pathway
R-HSA-422475 Axon guidance
R-HSA-422475 Axon guidance
R-HSA-437239 Recycling pathway of L1
R-HSA-437239 Recycling pathway of L1
R-HSA-5099900 WNT5A-dependent internalization of FZD4
R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-HSA-5653656 Vesicle-mediated transport
R-HSA-5663205 Infectious disease
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8866427 VLDLR internalisation and degradation
R-HSA-8964038 LDL clearance
R-HSA-8964043 Plasma lipoprotein clearance
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9675108 Nervous system development
R-HSA-9675108 Nervous system development
R-HSA-9679191 Potential therapeutics for SARS
R-HSA-9679506 SARS-CoV Infections
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007124 BXGD000437 Noninfiltrating Intraductal Carcinoma Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0017601 BXGD001125 Glaucoma Eye Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0025286 BXGD001850 Meningioma Neoplasms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032181 BXGD002332 Platelet Count measurement
C0035412 BXGD002548 Rhabdomyosarcoma Neoplasms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200665 BXGD004045 Platelet mean volume determination (procedure)
C0206161 BXGD004167 Reticulocyte count (procedure)
C0206655 BXGD004218 Alveolar rhabdomyosarcoma Neoplasms
C0262404 BXGD005236 Cerebellar degeneration Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0278877 BXGD006608 Adult Meningioma Neoplasms; Nervous System Diseases
C0279563 BXGD006637 Lobular carcinoma in situ of breast Neoplasms; Skin and Connective Tissue Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0427460 BXGD008616 Red cell distribution width determination
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0596887 BXGD009648 mathematical ability
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0740392 BXGD009988 Infarction, Middle Cerebral Artery Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1762616 BXGD013753 Meningioma, benign, no ICD-O subtype Neoplasms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C3711383 BXGD019388 Early-Onset Glaucoma Eye Diseases
C3828530 BXGD019744 Platelet Component Distribution Width Measurement
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein