Showing entry for Voltage-dependent L-type calcium channel subunit beta-1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012659
Protein NameVoltage-dependent L-type calcium channel subunit beta-1
Uniport IdQ02641
GeneCACNB1
Gene Id782
DomainGuanylate_kin; VGCC_beta4_N
Pfam PF00625   PF12052  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061337 cardiac conduction
Biological Process GO:1904646 cellular response to amyloid-beta
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0007528 neuromuscular junction development
Biological Process GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
Biological Process GO:1901385 regulation of voltage-gated calcium channel activity
molecular function GO:0008331 high voltage-gated calcium channel activity
molecular function GO:0005245 voltage-gated calcium channel activity
cellular component GO:0005886 plasma membrane
cellular component GO:0042383 sarcolemma
cellular component GO:0045202 synapse
cellular component GO:0005891 voltage-gated calcium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-112308 Presynaptic depolarization and calcium channel opening
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1266738 Developmental Biology
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-397014 Muscle contraction
R-HSA-419037 NCAM1 interactions
R-HSA-422475 Axon guidance
R-HSA-5576891 Cardiac conduction
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5576893 Phase 2 - plateau phase
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0596887 BXGD009648 mathematical ability
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0861353 BXGD011247 Noninvasive ductal carcinoma
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0003611 Latex 416.57
BXGC0006372 Ergocalciferol 396.65
BXGC0007525 (-)-Menthol 156.27
BXGC0024988 Nifedipine 346.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein