acompound

Showing entry for (-)-Menthol

General Compound Information
BXGC Id	BXGC0007525
Compound Name	(-)-Menthol
Structure
Formula	C10H20O
InchiKey	NOOLISFMXDJSKH-KXUCPTDWSA-N
SMILES	CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O
Inchi	InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
IUPAC	(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol
Molecular Weight	156.27
Pubchem Id	16666
Chembl Id	CHEMBL470670

Targets of Information Source

DrugBank

DB00825

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Groups	Target Type
Q7Z2W7	BXGT017248	Transient receptor potential cation channel subfamily M member 8	reviewed	Ion channel	TRPM8	approved	inducer
O75762	BXGT005151	Transient receptor potential cation channel subfamily A member 1	reviewed	Ion channel	TRPA1	approved	inducer
Q8NET8	BXGT018557	Transient receptor potential cation channel subfamily V member 3	reviewed	Ion channel	TRPV3	approved	inducer
P41145	BXGT010225	Kappa-type opioid receptor	reviewed	G-protein coupled receptor	OPRK1	approved	agonist
Q13936	BXGT013404	Voltage-dependent L-type calcium channel subunit alpha-1C	reviewed	Ion channel	CACNA1C	approved	-
Q01668	BXGT012605	Voltage-dependent L-type calcium channel subunit alpha-1D	reviewed	Ion channel	CACNA1D	approved	-
O60840	BXGT004901	Voltage-dependent L-type calcium channel subunit alpha-1F	reviewed	Ion channel	CACNA1F	approved	-
Q13698	BXGT013392	Voltage-dependent L-type calcium channel subunit alpha-1S	reviewed	Ion channel	CACNA1S	approved	-
Q02641	BXGT012659	Voltage-dependent L-type calcium channel subunit beta-1	reviewed	Ion channel	CACNB1	approved	-
Q08289	BXGT012979	Voltage-dependent L-type calcium channel subunit beta-2	reviewed	Ion channel	CACNB2	approved	-
P54284	BXGT011039	Voltage-dependent L-type calcium channel subunit beta-3	reviewed	Ion channel	CACNB3	approved	-
O00305	BXGT003907	Voltage-dependent L-type calcium channel subunit beta-4	reviewed	Ion channel	CACNB4	approved	-
O00555	BXGT003936	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	reviewed	Ion channel	CACNA1A	approved	antagonist

PDB

n.a

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	Ka M-1

Binding DB

50318482

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Ki nM	ic50 nM	Kd nM	EC50 nM
reviewed	BXGT018684	Transient receptor potential cation channel subfamily M member 8	reviewed		Trpm8	-	-	-	75000
reviewed	BXGT005151	Transient receptor potential cation channel subfamily A member 1	reviewed	Ion channel	TRPA1	-	-	-	28400
reviewed	BXGT017916	Transient receptor potential cation channel subfamily A member 1	reviewed		Trpa1	-	-	-	56000
reviewed	BXGT017248	Transient receptor potential cation channel subfamily M member 8	reviewed	Ion channel	TRPM8	-	92000	-	-
reviewed	BXGT017248	Transient receptor potential cation channel subfamily M member 8	reviewed	Ion channel	TRPM8	-	-	14400	-
reviewed	BXGT017248	Transient receptor potential cation channel subfamily M member 8	reviewed	Ion channel	TRPM8	-	-	-	29000
reviewed	BXGT017248	Transient receptor potential cation channel subfamily M member 8	reviewed	Ion channel	TRPM8	-	-	-	3000

CHEMBL

CHEMBL470670

Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	width="10%">Type	Relation	value	Units
Uniport Id	BXGT Id	Protein Name	Status	Protein Class	Gene	Type	Relation	value	Units
P22310	BXGT008754	UDP-glucuronosyltransferase 1-4	reviewed	-	UGT1A4	Activity	'='	41	pm/min/mg
P35354	BXGT009816	Prostaglandin G/H synthase 2	reviewed	Enzyme	PTGS2	Inhibition	'='	60	%
Q8NHB7	BXGT018568	Olfactory receptor 5K1	reviewed	-	OR5K1	Inhibition	'>='	50	%
P15381	BXGT008115	Voltage-dependent L-type calcium channel subunit alpha-1C	reviewed	-	CACNA1C	IC50	'='	74600	nM
P0DTE4	BXGT022286	UDP-glucuronosyltransferase 2A1	reviewed	-	UGT2A1	Activity	'='	32	pm/min/mg
P35354	BXGT009816	Prostaglandin G/H synthase 2	reviewed	Enzyme	PTGS2	Inhibition	'<'	30	%
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	reviewed	-	APEX1	Potency	-	50	nM
Q7Z2W7	BXGT017248	Transient receptor potential cation channel subfamily M member 8	reviewed	Ion channel	TRPM8	Activity	-	-	-
O75762	BXGT005151	Transient receptor potential cation channel subfamily A member 1	reviewed	Ion channel	TRPA1	EC50	'='	96000	nM
Q7Z2W7	BXGT017248	Transient receptor potential cation channel subfamily M member 8	reviewed	Ion channel	TRPM8	EC50	'='	10100	nM

Foods containing the compound

Foods

BXGF Id	Food Name	Scientific Name	Food Group
BXGF Id	Food Name	Scientific Name	Food Group
BXGF00019	Tarragon	Artemisia dracunculus	Herbs and Spices
BXGF00038	Tea	Camellia sinensis	Teas
BXGF00040	Pepper (C. annuum)	Capsicum annuum	Vegetables
BXGF00086	Sunflower	Helianthus annuus	Herbs and Spices
BXGF00100	Lovage	Levisticum officinale	Herbs and Spices
BXGF00109	Mentha (Mint)	Mentha	Herbs and Spices
BXGF00110	Orange mint	Mentha aquatica	Herbs and Spices
BXGF00111	Cornmint	Mentha arvensis	Herbs and Spices
BXGF00112	Spearmint	Mentha spicata	Herbs and Spices
BXGF00113	Peppermint	Mentha X piperita	Herbs and Spices
BXGF00115	Bitter gourd	Momordica charantia	Gourds
BXGF00119	Sweet basil	Ocimum basilicum	Herbs and Spices
BXGF00122	Sweet marjoram	Origanum majorana	Herbs and Spices
BXGF00150	Guava	Psidium guajava	Fruits
BXGF00165	Common sage	Salvia officinalis	Herbs and Spices
BXGF00166	Black elderberry	Sambucus nigra	Fruits
BXGF00183	Common thyme	Thymus vulgaris	Herbs and Spices
BXGF00205	Corn	Zea mays	Cereals and cereal products
BXGF00310	Coconut	Cocos nucifera	Fruits
BXGF00803	Cabbage	Brassica oleracea var. capitata	Vegetables
BXGF00818	Herbs and Spices		Herbs and Spices
BXGF00839	White cabbage	Brassica oleracea L. var. capitata L. f. alba DC.	Vegetables
BXGF00946	Artemisia montana	Artemisia montana	Medicinal Plant
BXGF00959	Artemisia hanseniana	Artemisia hanseniana	Others
BXGF01048	Paederia scandens	Paederia scandens	Medicinal Plant
BXGF01074	Centella asiatica	Centella asiatica	Medicinal Plant
BXGF01081	Akebia trifoliata	Akebia trifoliata	Medicinal Plant
BXGF01151	Ligusticum jeholense	Ligusticum jeholense	Medicinal Plant
BXGF01159	Kopsia grandifolia	Kopsia grandifolia	Others
BXGF01245	Amomum villosum	Amomum villosum	Medicinal Plant
BXGF01281	Ledebouria socialis	Ledebouria socialis	Others
BXGF01361	Lycopus europaeus	Lycopus europaeus	Medicinal Plant
BXGF01400	Dipterocarpus dyeri	Dipterocarpus dyeri	Others
BXGF01506	Thymus quinquecostatus	Thymus quinquecostatus	Medicinal Plant
BXGF01518	Ipomoea cairica	Ipomoea cairica	Medicinal Plant
BXGF01699	Ceanothus velutinus	Ceanothus velutinus	Medicinal Plant
BXGF01716	Mentha canadensis	Mentha canadensis	Medicinal Plant
BXGF01732	Garcinia scortechinii	Garcinia scortechinii	Others
BXGF01756	Apollonias barbujana	Apollonias barbujana	Others
BXGF01781	Chlorophytum borivilianum	Chlorophytum borivilianum	Medicinal Plant
BXGF01868	Vitex negundo	Vitex negundo	Medicinal Plant
BXGF01902	Amomum longiligulare	Amomum longiligulare	Medicinal Plant
BXGF02024	Actaea dahurica	Actaea dahurica	Human Edible Plant
BXGF02143	Actaea cimicifuga	Actaea cimicifuga	Medicinal Plant
BXGF02167	Scutellaria barbata	Scutellaria barbata	Medicinal Plant
BXGF02238	Amomum xanthioides	Amomum xanthioides	Medicinal Plant
BXGF02316	Isodon lophanthoides	Isodon lophanthoides	Medicinal Plant
BXGF02596	Fragaria vesca	Fragaria vesca	Medicinal Plant
BXGF02604	Agrimonia pilosa	Agrimonia pilosa	Medicinal Plant
BXGF02612	Mosla chinensis	Mosla chinensis	Medicinal Plant
BXGF02756	Schizonepeta tenuisfolia	Schizonepeta tenuisfolia	Others
BXGF02792	Ligusticum sinense	Ligusticum sinense	Medicinal Plant
BXGF02815	Pinellia ternata	Pinellia ternata	Medicinal Plant
BXGF02927	Akebia quinata	Akebia quinata	Medicinal Plant
BXGF03090	Lasianthus fordii	Lasianthus fordii	Others
BXGF03162	Atractylodes macrocephala	Atractylodes macrocephala	Medicinal Plant
BXGF03243	Elsholtzia ciliata	Elsholtzia ciliata	Medicinal Plant
BXGF03290	Ligusticum tenuissimum	Ligusticum tenuissimum	Medicinal Plant
BXGF03414	Centranthus longiflorus ssp. longiflorus	Centranthus longiflorus ssp. longiflorus	Others
BXGF03671	Leonurus japonicus	Leonurus japonicus	Medicinal Plant
BXGF03953	Artemisia princeps	Artemisia princeps	Medicinal Plant
BXGF04402	Actaea simplex	Actaea simplex	Others
BXGF04602	Platycladus orientalis	Platycladus orientalis	Medicinal Plant
BXGF04605	Senna alexandrina	Senna alexandrina	Medicinal Plant
BXGF04611	Artemisia argyi	Artemisia argyi	Medicinal Plant
BXGF05096	Aconitum leucostomum	Aconitum leucostomum	Medicinal Plant
BXGF05200	Aquilegia ecalcarata	Aquilegia ecalcarata	Medicinal Plant
BXGF05316	Persea mexicana	Persea mexicana	Others
BXGF05442	Zanthoxylum bungeanum	Zanthoxylum bungeanum	Medicinal Plant
BXGF05767	Gardenia tubifera	Gardenia tubifera	Medicinal Plant
BXGF05845	Panax innovans	Panax innovans	Others
BXGF05956	Blumea mollis	Blumea mollis	Medicinal Plant
BXGF06070	Perilla frutescens	Perilla frutescens	Medicinal Plant
BXGF06075	Zanthoxylum schinifolium	Zanthoxylum schinifolium	Medicinal Plant
BXGF06092	Schizonepeta tenuifolia	Schizonepeta tenuifolia	Medicinal Plant

The compound-realted diseases

Diseases

BXGD Id	Disease Name	CUI Disease Id	Disease Class Name	Number of targets^{?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease}