Showing entry for Nifedipine


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0024988
Compound NameNifedipine
Structure
FormulaC17H18N2O6
InchiKeyHYIMSNHJOBLJNT-UHFFFAOYSA-N
SMILESCOC(=O)C1=C(C)NC(=C(C1c1ccccc1N(=O)=O)C(=O)OC)C
InchiInChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
IUPACdimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Molecular Weight346.12
Pubchem Id4485
Chembl IdCHEMBL193
Targets of Information Source
DrugBank DB01115
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C approved inhibitor
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 reviewed Nuclear receptor NR1I2 approved agonist
P0DP23 BXGT007520 Calmodulin-1 reviewed - CALM1 approved inhibitor
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D approved inhibitor
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S approved inhibitor
Q08289 BXGT012979 Voltage-dependent L-type calcium channel subunit beta-2 reviewed Ion channel CACNB2 approved inhibitor
Q9UK17 BXGT021735 Potassium voltage-gated channel subfamily D member 3 reviewed Ion channel KCND3 approved inhibitor
O43497 BXGT004596 Voltage-dependent T-type calcium channel subunit alpha-1G reviewed Ion channel CACNA1G approved -
O95180 BXGT005358 Voltage-dependent T-type calcium channel subunit alpha-1H reviewed Ion channel CACNA1H approved -
Q9P0X4 BXGT021293 Voltage-dependent T-type calcium channel subunit alpha-1I reviewed Ion channel CACNA1I approved inhibitor
PDB C5U
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P07293 BXGT006593 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed CACNA1S - - - - -
Binding DB 50101817
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT005348 Potassium channel subfamily K member 2 reviewed Ion channel KCNK2 - - - 8180
reviewed BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C - 22 - -
reviewed BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C (Fragment) reviewed CACNA1C - 50 - -
reviewed BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C - 55 - -
reviewed BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C (Fragment) reviewed CACNA1C - 260 - -
reviewed BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C (Fragment) reviewed CACNA1C - 300 - -
reviewed BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C - 50 - -
reviewed BXGT005373 Bile salt export pump reviewed Transporter ABCB11 - 30700 - -
reviewed BXGT005057 Bile salt export pump reviewed Abcb11 - 45400 - -
reviewed BXGT010867 Cytochrome P450 2J2 reviewed CYP2J2 - 3060 - -
reviewed BXGT007738 Cytochrome P450 2C9 reviewed CYP2C9 - 4080 - -
reviewed BXGT009707 Cytochrome P450 2C19 reviewed CYP2C19 - 5420 - -
reviewed BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 - 5620 - -
reviewed BXGT007595 Cytochrome P450 2D6 reviewed CYP2D6 - >50000 - -
reviewed BXGT013591 Myosin light chain kinase, smooth muscle reviewed Kinase MYLK - 2020 - -
reviewed BXGT008160 Alpha-1B adrenergic receptor reviewed Adra1b >1000 - - -
reviewed BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A - 37000 - -
CHEMBL CHEMBL193
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '=' 280000 nM
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Kd '=' 0 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki '>' 1000 nM
P23944 BXGT008930 Alpha-1D adrenergic receptor reviewed - Adra1d Ki '>' 1000 nM
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki '>' 1000 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 28183 nM
O60240 BXGT004860 Perilipin-1 reviewed - PLIN1 IC50 '=' 9619 nM
Q8WTS1 BXGT018985 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 reviewed - ABHD5 IC50 '=' 9619 nM
Q02410 BXGT012652 Amyloid-beta A4 precursor protein-binding family A member 1 reviewed Transporter APBA1 IC50 '=' 10100 nM
Q00975 BXGT012558 Voltage-dependent N-type calcium channel subunit alpha-1B reviewed Ion channel CACNA1B IC50 '=' 10100 nM
Q01453 BXGT012588 Peripheral myelin protein 22 reviewed Cellular structure PMP22 Potency '=' 75686 nM
P16473 BXGT008234 Thyrotropin receptor reviewed G-protein coupled receptor TSHR Potency '=' 158 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 2818 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 IC50 - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Ki - - -
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 5623 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 28183 nM
P00811 BXGT005666 Beta-lactamase reviewed - ampC Potency '=' 354 nM
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R IC50 - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 Ki - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE IC50 - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 AC50 - - -
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Ki '=' 4 nM
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Ki '=' 4 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Ki '=' 4 nM
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B Ki - - -
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 Ki - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Activity - - -
Q02410 BXGT012652 Amyloid-beta A4 precursor protein-binding family A member 1 reviewed Transporter APBA1 IC50 '=' 1120 nM
Q00975 BXGT012558 Voltage-dependent N-type calcium channel subunit alpha-1B reviewed Ion channel CACNA1B IC50 '=' 1120 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 18348 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 '=' 15848 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '=' 50118 nM
P54132 BXGT011032 Bloom syndrome protein reviewed - BLM Potency '=' 3981 nM
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 IC50 - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 IC50 - - -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 8912 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 IC50 - - -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 3981 nM
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 IC50 - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Inhibition - - -
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Ki - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 Ki - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Ki - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 IC50 - - -
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 Ki - - -
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 31622 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 5173 nM
O35505 BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C IC50 '=' 300 nM
O35505 BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C IC50 '=' 50 nM
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE Ki - - -
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 Ki - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 IC50 - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 Ki - - -
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 22387 nM
P0DP23 BXGT007520 Calmodulin-1 reviewed - CALM1 IC50 - - -
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 11220 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 12589 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 50118 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 1 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 25118 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 12995 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 11220 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 3162 nM
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 11220 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 39 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 56234 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 '=' 275000 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Potency - 50118 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 '=' 2300 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 1000 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 4466 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 50118 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 29092 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d EC50 '=' 12 nM
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s EC50 '=' 12 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c EC50 '=' 12 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 75 %
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Ki '=' 1 nM
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Potency '=' 11220 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 14125 nM
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A Ki - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 8912 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 6309 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 15848 nM
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 11220 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition '=' 46 %
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C IC50 '=' 50 nM
Q8WTS1 BXGT018985 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 reviewed - ABHD5 IC50 '=' 7133 nM
Q00G26 BXGT012560 Perilipin-5 reviewed - PLIN5 IC50 '=' 7133 nM
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Ki - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN IC50 - - -
P06241 BXGT006429 Tyrosine-protein kinase Fyn reviewed Kinase FYN Ki - - -
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 29934 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 3162 nM
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F #NAME? '=' 9 -
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D #NAME? '=' 9 -
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S #NAME? '=' 9 -
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C #NAME? '=' 9 -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Inhibition '=' 88 %
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 17782 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 7943 nM
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 22387 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 15848 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '<' 10000 nM
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 ID50 '=' 1 M
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 ID50 '=' 1 M
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 ID50 '=' 1 M
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 ID50 '=' 1 M
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 ID50 '=' 1 M
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 25118 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 31622 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '<' 10000 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Ki '=' 1 nM
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 Ki - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 IC50 '=' 2191 nM
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 Ki - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 Ki - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 Ki - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Ki - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 Ki - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 IC50 - - -
P02545 BXGT005889 Prelamin-A/C reviewed - LMNA Potency '=' 1122 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 2890 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 14125 nM
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 39810 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 12589 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 28183 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 15848 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 AC50 '=' 50 nM
P15381 BXGT008115 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C T1/2 '=' 0 hr
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio_ATPase activity '=' 2 -
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition '=' 28 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Inhibition '=' 28 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition '=' 28 %
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition '=' 8 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Inhibition '=' 8 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition '=' 8 %
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 3548 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 12589 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 '=' 10000 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 '=' 46989 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 42163 nM
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R IC50 - - -
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 Ki - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 IC50 - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 - - -
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A Inhibition '=' 26 %
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A Inhibition '=' 26 %
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A Inhibition '=' 26 %
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA Ki - - -
P28223 BXGT009239 5-hydroxytryptamine receptor 2A reviewed G-protein coupled receptor HTR2A IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC IC50 - - -
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 4466 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 31622 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 244000 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 AC50 - - -
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A IC50 - - -
P0DP23 BXGT007520 Calmodulin-1 reviewed - CALM1 Ratio IC50 - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 - - -
P97697 BXGT012214 Inositol monophosphatase 1 reviewed - Impa1 Potency '=' 8912 nM
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Inhibition - - -
P40225 BXGT010168 Thrombopoietin reviewed - THPO Potency '=' 1584 nM
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R IC50 - - -
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Potency - 5173 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 12589 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 9441 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C IC50 '=' 18273 nM
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 IC50 - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 Ki - - -
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 35481 nM
P00390 BXGT005526 Glutathione reductase, mitochondrial reviewed Enzyme GSR IC50 '=' 23400 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 31622 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 8912 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 28183 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 12589 nM
Q9NR56 BXGT021179 Muscleblind-like protein 1 reviewed Nucleic acid binding MBNL1 Potency - 79432 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 28183 nM
P24557 BXGT008976 Thromboxane-A synthase reviewed - TBXAS1 IC50 '=' 18594 nM
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 IC50 - - -
P32241 BXGT009613 Vasoactive intestinal polypeptide receptor 1 reviewed G-protein coupled receptor VIPR1 Ki - - -
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 37685 nM
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Ki '=' 22200 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Inhibition - - -
P84022 BXGT012027 Mothers against decapentaplegic homolog 3 reviewed Transcription factor SMAD3 Potency - 35481 nM
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 15848 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 29092 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '=' 610 nm/s
Q9Y5Y9 BXGT022309 Sodium channel protein type 10 subunit alpha reviewed Ion channel SCN10A IC50 '=' 37000 nM
Q9UQD0 BXGT021811 Sodium channel protein type 8 subunit alpha reviewed Ion channel SCN8A IC50 '=' 37000 nM
Q9UI33 BXGT021712 Sodium channel protein type 11 subunit alpha reviewed Ion channel SCN11A IC50 '=' 37000 nM
Q9NY46 BXGT021248 Sodium channel protein type 3 subunit alpha reviewed Ion channel SCN3A IC50 '=' 37000 nM
Q15858 BXGT013610 Sodium channel protein type 9 subunit alpha reviewed Ion channel SCN9A IC50 '=' 37000 nM
Q99250 BXGT019913 Sodium channel protein type 2 subunit alpha reviewed Ion channel SCN2A IC50 '=' 37000 nM
Q01118 BXGT012570 Sodium channel protein type 7 subunit alpha reviewed Ion channel SCN7A IC50 '=' 37000 nM
P35499 BXGT009839 Sodium channel protein type 4 subunit alpha reviewed Ion channel SCN4A IC50 '=' 37000 nM
Q14524 BXGT013478 Sodium channel protein type 5 subunit alpha reviewed Ion channel SCN5A IC50 '=' 37000 nM
P35498 BXGT009838 Sodium channel protein type 1 subunit alpha reviewed Ion channel SCN1A IC50 '=' 37000 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 30700 nM
P08482 BXGT006775 Muscarinic acetylcholine receptor M1 reviewed - Chrm1 Potency '=' 15848 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 39810 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 10000 nM
Q16665 BXGT013653 Hypoxia-inducible factor 1-alpha reviewed Transcription factor HIF1A Potency '=' 501 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Inhibition - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 '=' 4080 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d IC50 '=' 2 nM
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s IC50 '=' 2 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 2 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition '=' 0 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Inhibition '=' 0 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition '=' 0 %
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition '=' 68 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Inhibition '=' 68 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition '=' 68 %
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 IC50 - - -
P08575 BXGT006793 Receptor-type tyrosine-protein phosphatase C reviewed Enzyme PTPRC Ki - - -
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 IC50 - - -
P14416 BXGT008011 D(2) dopamine receptor reviewed G-protein coupled receptor DRD2 IC50 - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 44668 nM
P41145 BXGT010225 Kappa-type opioid receptor reviewed G-protein coupled receptor OPRK1 Ki - - -
O35505 BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C IC50 '=' 69 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 7079 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d IC50 '=' 27 nM
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s IC50 '=' 27 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 27 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Inhibition '<' 50 %
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Activity - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A IC50 - - -
P19793 BXGT008515 Retinoic acid receptor RXR-alpha reviewed Nuclear receptor RXRA Potency - 44668 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 39810 nM
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 79432 nM
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 IC50 - - -
O35505 BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C IC50 '=' 2 nM
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Potency - 4744 nM
Q9JIS7 BXGT020822 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed - Cacna1f Inhibition - - -
Q99246 BXGT019912 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition - - -
Q02789 BXGT012671 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Inhibition - - -
Q01815 BXGT012619 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition - - -
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 39810 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 22387 nM
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 - - -
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d IC50 '=' 1 nM
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s IC50 '=' 1 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 1 nM
P15381 BXGT008115 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C IC50 '=' 2 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 12589 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 7079 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Papp '=' 765 nm/s
O75496 BXGT005132 Geminin reviewed - GMNN Potency '=' 12589 nM
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Ki - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 IC50 - - -
P29477 BXGT009355 Nitric oxide synthase, inducible reviewed - Nos2 Ki - - -
O76074 BXGT005174 cGMP-specific 3',5'-cyclic phosphodiesterase reviewed - PDE5A IC50 - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR Ki - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE Ki - - -
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '=' 4078 nM
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 Ki - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 IC50 '=' 300 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 - - -
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 - - -
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA IC50 - - -
P35372 BXGT009823 Mu-type opioid receptor reviewed G-protein coupled receptor OPRM1 IC50 - - -
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D Ki - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 IC50 - - -
P15381 BXGT008115 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C IC50 '=' 1 nM
P50406 BXGT010796 5-hydroxytryptamine receptor 6 reviewed G-protein coupled receptor HTR6 Ki - - -
Q99720 BXGT019955 Sigma non-opioid intracellular receptor 1 reviewed - SIGMAR1 IC50 - - -
P25103 BXGT009020 Substance-P receptor reviewed G-protein coupled receptor TACR1 Ki - - -
P15207 BXGT008096 Androgen receptor reviewed - Ar Ki - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 IC50 - - -
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Ki - - -
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 2119 nM
P12530 BXGT007827 Arachidonate 15-lipoxygenase reviewed - ALOX15 IC50 '=' 15101 nM
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 IC50 - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Ki - - -
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 Ki - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 Ki - - -
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a IC50 - - -
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d IC50 '=' 2 nM
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s IC50 '=' 2 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 2 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 3981 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Ki '=' 3 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 3548 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition '>' 50 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Inhibition '>' 50 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition '>' 50 %
P22303 BXGT008751 Acetylcholinesterase reviewed Enzyme ACHE IC50 - - -
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 IC50 '=' 7701 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Ki '=' 4492 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a Ki - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B IC50 - - -
P50052 BXGT010768 Type-2 angiotensin II receptor reviewed G-protein coupled receptor AGTR2 Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 Ki - - -
P25024 BXGT009005 C-X-C chemokine receptor type 1 reviewed G-protein coupled receptor CXCR1 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 Ki - - -
P05181 BXGT006337 Cytochrome P450 2E1 reviewed - CYP2E1 Ki - - -
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 22387 nM
P48776 BXGT010663 Tryptophan 2,3-dioxygenase reviewed - Tdo2 Inhibition '<' 20 %
Q8R0V5 BXGT018678 Indoleamine 2,3-dioxygenase 2 reviewed - Ido2 Inhibition '>=' 55 %
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 11220 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 12589 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Selectivity index '=' 8 -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 10000 nM
O94956 BXGT005343 Solute carrier organic anion transporter family member 2B1 reviewed Transporter SLCO2B1 Inhibition '=' -44 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 25118 nM
O75469 BXGT005128 Nuclear receptor subfamily 1 group I member 2 reviewed Nuclear receptor NR1I2 Activity - - -
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 19952 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 2993 nM
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 10000 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 7079 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 12559 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d IC50 '=' 2 nM
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s IC50 '=' 2 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 2 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 IC50 - - -
P28564 BXGT009272 5-hydroxytryptamine receptor 1B reviewed - Htr1b IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 Ki - - -
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 15848 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition - - -
P21452 BXGT008653 Substance-K receptor reviewed G-protein coupled receptor TACR2 Ki - - -
Q64133 BXGT016109 Amine oxidase [flavin-containing] A reviewed - Maoa Activity - - -
P15823 BXGT008160 Alpha-1B adrenergic receptor reviewed - Adra1b IC50 - - -
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 IC50 - - -
P35354 BXGT009816 Prostaglandin G/H synthase 2 reviewed Enzyme PTGS2 IC50 - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 12995 nM
P43140 BXGT010360 Alpha-1A adrenergic receptor reviewed - Adra1a IC50 - - -
P08913 BXGT006841 Alpha-2A adrenergic receptor reviewed G-protein coupled receptor ADRA2A Ki - - -
P00918 BXGT005690 Carbonic anhydrase 2 reviewed - CA2 IC50 - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 IC50 - - -
P25025 BXGT009006 C-X-C chemokine receptor type 2 reviewed G-protein coupled receptor CXCR2 IC50 - - -
P11509 BXGT007716 Cytochrome P450 2A6 reviewed - CYP2A6 IC50 - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 - - -
P18089 BXGT008379 Alpha-2B adrenergic receptor reviewed G-protein coupled receptor ADRA2B Ki - - -
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 Ki - - -
P49798 BXGT010745 Regulator of G-protein signaling 4 reviewed Enzyme modulator RGS4 Potency - 59 nM
Q8BLA8 BXGT017916 Transient receptor potential cation channel subfamily A member 1 reviewed - Trpa1 EC50 '=' 400 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 15848 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 17782 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Ki '=' 8290 nM
P22460 BXGT008774 Potassium voltage-gated channel subfamily A member 5 reviewed Ion channel KCNA5 IC50 '=' 6100 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Potency - 50118 nM
P30411 BXGT009424 B2 bradykinin receptor reviewed G-protein coupled receptor BDKRB2 Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR IC50 - - -
P23219 BXGT008837 Prostaglandin G/H synthase 1 reviewed Enzyme PTGS1 IC50 - - -
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb IC50 - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 IC50 - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 IC50 - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 IC50 - - -
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase reviewed - HMGCR Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S IC50 - - -
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R IC50 - - -
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 IC50 '=' 7214 nM
P08588 BXGT006795 Beta-1 adrenergic receptor reviewed G-protein coupled receptor ADRB1 IC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Ki - - -
P25094 BXGT009014 Peripheral myelin protein 22 reviewed - Pmp22 Potency - 18105 nM
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 35481 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 849 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 19952 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Blockage '=' 67 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Blockage '=' 67 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Blockage '=' 67 %
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 17740 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 20596 nM
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F Binding energy '=' -12 kCal M-1
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D Binding energy '=' -12 kCal M-1
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S Binding energy '=' -12 kCal M-1
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Binding energy '=' -12 kCal M-1
P08912 BXGT006840 Muscarinic acetylcholine receptor M5 reviewed G-protein coupled receptor CHRM5 ID50 '=' 0 M
P08172 BXGT006737 Muscarinic acetylcholine receptor M2 reviewed G-protein coupled receptor CHRM2 ID50 '=' 0 M
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 ID50 '=' 0 M
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 ID50 '=' 0 M
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 ID50 '=' 0 M
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Inhibition - - -
P21917 BXGT008707 D(4) dopamine receptor reviewed G-protein coupled receptor DRD4 Ki - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A IC50 - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 Ki - - -
P30988 BXGT009491 Calcitonin receptor reviewed G-protein coupled receptor CALCR Ki - - -
P32238 BXGT009611 Cholecystokinin receptor type A reviewed G-protein coupled receptor CCKAR Ki - - -
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Ki - - -
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition '=' 78 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Inhibition '=' 78 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition '=' 78 %
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 31622 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 7943 nM
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F Binding energy '=' -10 kCal M-1
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D Binding energy '=' -10 kCal M-1
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S Binding energy '=' -10 kCal M-1
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Binding energy '=' -10 kCal M-1
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d IC50 '=' 2 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 15848 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 10322 nM
Q9JIS7 BXGT020822 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed - Cacna1f IC50 '=' 1200 nM
Q99246 BXGT019912 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d IC50 '=' 1200 nM
Q02789 BXGT012671 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s IC50 '=' 1200 nM
Q01815 BXGT012619 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 1200 nM
P10275 BXGT007552 Androgen receptor reviewed Nuclear receptor AR Potency - 31622 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 59557 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Block '=' 66 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Block '=' 66 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Block '=' 66 %
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 7943 nM
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F Binding energy '=' -13 kCal M-1
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D Binding energy '=' -13 kCal M-1
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S Binding energy '=' -13 kCal M-1
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Binding energy '=' -13 kCal M-1
Q92887 BXGT019389 Canalicular multispecific organic anion transporter 1 reviewed Transporter ABCC2 IC50 '=' 133000 nM
O15296 BXGT004148 Arachidonate 15-lipoxygenase B reviewed Enzyme ALOX15B Potency - 10000 nM
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 IC50 '>' 50000 nM
P19327 BXGT008472 5-hydroxytryptamine receptor 1A reviewed - Htr1a Ki - - -
P37288 BXGT009977 Vasopressin V1a receptor reviewed G-protein coupled receptor AVPR1A Ki - - -
Q92731 BXGT019366 Estrogen receptor beta reviewed Nuclear receptor ESR2 IC50 - - -
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr Ki - - -
A6XA80 BXGT001522 Leukotriene C4 synthase reviewed - LTC4S Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R IC50 - - -
P29476 BXGT009354 Nitric oxide synthase, brain reviewed - Nos1 IC50 - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 IC50 - - -
P03956 BXGT006120 Interstitial collagenase reviewed Enzyme MMP1 Ki - - -
Q08209 BXGT012968 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform reviewed - PPP3CA IC50 - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 25118 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 1122 nM
P81908 BXGT011959 Cholinesterase reviewed - BCHE Ki '=' 1200 nM
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C IC50 '=' 22 nM
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F IC50 '=' 10 nM
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D IC50 '=' 10 nM
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S IC50 '=' 10 nM
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C IC50 '=' 10 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 15848 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 22387 nM
P15381 BXGT008115 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C Inhibition '=' 69 %
P18054 BXGT008370 Arachidonate 12-lipoxygenase, 12S-type reviewed Enzyme ALOX12 Potency '=' 31622 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 7943 nM
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Ki - - -
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 - - -
P33032 BXGT009689 Melanocortin receptor 5 reviewed G-protein coupled receptor MC5R Ki - - -
P49146 BXGT010681 Neuropeptide Y receptor type 2 reviewed G-protein coupled receptor NPY2R Ki - - -
Q690N0 BXGT016199 Progesterone receptor unreviewed - PGR IC50 - - -
P12822 BXGT007850 Angiotensin-converting enzyme reviewed - ACE Ki - - -
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 39810 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 22387 nM
Q9R1A7 BXGT021413 Nuclear receptor subfamily 1 group I member 2 reviewed - Nr1i2 Potency - 70794 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 472000 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '<' 10000 nM
P49430 BXGT010707 Thromboxane-A synthase reviewed - Tbxas1 IC50 '>' 10000 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 39810 nM
Q96RI1 BXGT019727 Bile acid receptor reviewed Nuclear receptor NR1H4 Potency - 25118 nM
P07943 BXGT006700 Aldo-keto reductase family 1 member B1 reviewed - Akr1b1 IC50 - - -
P41597 BXGT010268 C-C chemokine receptor type 2 reviewed - CCR2 Ki '=' 847 nM
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 Ki - - -
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA Ki - - -
P51679 BXGT010877 C-C chemokine receptor type 4 reviewed G-protein coupled receptor CCR4 Ki - - -
P31645 BXGT009558 Sodium-dependent serotonin transporter reviewed Transporter SLC6A4 Ki - - -
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 170 %
O70528 BXGT005068 5-hydroxytryptamine receptor 4 reviewed - HTR4 Ki - - -
P41595 BXGT010267 5-hydroxytryptamine receptor 2B reviewed G-protein coupled receptor HTR2B IC50 - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Ratio_Papp '=' 1 -
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F Relative activity '=' 100 -
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D Relative activity '=' 100 -
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S Relative activity '=' 100 -
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Relative activity '=' 100 -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Rate of oxidation '=' 1 -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 18200 nM
P01375 BXGT005753 Tumor necrosis factor reviewed Signaling TNF Potency - 10590 nM
P42345 BXGT010304 Serine/threonine-protein kinase mTOR reviewed Kinase MTOR Potency '=' 16481 nM
P25101 BXGT009018 Endothelin-1 receptor reviewed G-protein coupled receptor EDNRA IC50 - - -
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 reviewed - IDO1 Inhibition '=' 0 %
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 23715 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 11220 nM
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Potency - 2592 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 5623 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Ki '=' 9572 nM
P21397 BXGT008644 Amine oxidase [flavin-containing] A reviewed - MAOA Ki - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 IC50 - - -
P08246 BXGT006756 Neutrophil elastase reviewed Enzyme ELANE IC50 - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 Ki - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 9200 nM
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Ki - - -
P20309 BXGT008562 Muscarinic acetylcholine receptor M3 reviewed G-protein coupled receptor CHRM3 IC50 - - -
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition '=' 55 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Inhibition '=' 55 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition '=' 55 %
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 56234 nM
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 IC50 - - -
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 58478 nM
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 IC50 - - -
P03372 BXGT006059 Estrogen receptor reviewed Nuclear receptor ESR1 IC50 - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 % maximum response '=' 34 %
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 AC50 '=' 7943 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 '=' 5620 nM
Q99700 BXGT019949 Ataxin-2 reviewed Nucleic acid binding ATXN2 Potency - 10000 nM
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 33498 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Ki '=' 251188 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29855 nM
Q8R0V5 BXGT018678 Indoleamine 2,3-dioxygenase 2 reviewed - Ido2 IC50 '=' 1500 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 8196 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 7943 nM
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 Potency - 31622 nM
O35505 BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C IC50 '=' 260 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 14125 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 15848 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d IC50 '=' 57 nM
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s IC50 '=' 57 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 57 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d IC50 '=' 27 nM
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s IC50 '=' 27 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c IC50 '=' 27 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 11885 nM
P15207 BXGT008096 Androgen receptor reviewed - Ar IC50 - - -
O15438 BXGT004168 Canalicular multispecific organic anion transporter 2 reviewed Transporter ABCC3 IC50 '=' 133000 nM
O00167 BXGT003887 Eyes absent homolog 2 reviewed - EYA2 Potency - 10692 nM
Q63120 BXGT016061 Canalicular multispecific organic anion transporter 1 reviewed - Abcc2 Activity - - -
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD Potency - 25118 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 IC50 - - -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Ki - - -
P35462 BXGT009835 D(3) dopamine receptor reviewed G-protein coupled receptor DRD3 IC50 - - -
Q01959 BXGT012624 Sodium-dependent dopamine transporter reviewed Transporter SLC6A3 IC50 - - -
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Ki '=' 4000 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Selectivity '=' 8 -
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Selectivity '=' 8 -
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Selectivity '=' 8 -
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Bmax1 '=' 100 %
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Kd1 '=' 0 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition '=' 39 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Inhibition '=' 39 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition '=' 39 %
P28776 BXGT009290 Indoleamine 2,3-dioxygenase 1 reviewed - Ido1 IC50 '=' 46000 nM
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 11220 nM
Q9F4F7 BXGT020344 4'-phosphopantetheinyl transferase ffp reviewed - ffp Potency '=' 37289 nM
O97447 BXGT005436 Putative fructose-1,6-bisphosphate aldolase unreviewed - ald Potency '=' 7924 nM
P20781 BXGT008598 Glycine receptor subunit beta reviewed - Glrb Ki - - -
P07727 BXGT006662 Glycine receptor subunit alpha-1 reviewed - Glra1 Ki - - -
P24524 BXGT008974 Glycine receptor subunit alpha-3 reviewed - Glra3 Ki - - -
P22771 BXGT008806 Glycine receptor subunit alpha-2 reviewed - Glra2 Ki - - -
Q9Y271 BXGT022222 Cysteinyl leukotriene receptor 1 reviewed G-protein coupled receptor CYSLTR1 Ki - - -
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 63095 nM
B2RX12 BXGT002004 Canalicular multispecific organic anion transporter 2 reviewed - Abcc3 Activity - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 10000 nM
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 56234 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition '=' 99 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Inhibition '=' 99 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition '=' 99 %
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D IC50 '=' 1350 nM
P21554 BXGT008662 Cannabinoid receptor 1 reviewed G-protein coupled receptor CNR1 Ki - - -
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 2592 nM
O35505 BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C IC30 '=' 1 10'-8M
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 25118 nM
P27732 BXGT009204 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed - Cacna1d Inhibition '=' 83 %
Q02485 BXGT012654 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed - Cacna1s Inhibition '=' 83 %
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition '=' 83 %
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 11582 nM
Q57TT1 BXGT015153 Uncharacterized protein unreviewed - Tb927.8.6820 Potency - 19952 nM
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 Ki - - -
P29466 BXGT009349 Caspase-1 reviewed Enzyme CASP1 IC50 - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG Ki - - -
Q8HY88 BXGT018198 Potassium channel subfamily K member 2 unreviewed - KCNK2 IC50 '=' 8200 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 69000 nM
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 IC50 '=' 113000 nM
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F IC50 '=' 60 nM
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D IC50 '=' 60 nM
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S IC50 '=' 60 nM
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C IC50 '=' 60 nM
O70127 BXGT005057 Bile salt export pump reviewed - Abcb11 IC50 '=' 45400 nM
P35367 BXGT009821 Histamine H1 receptor reviewed G-protein coupled receptor HRH1 Ki - - -
P25021 BXGT009004 Histamine H2 receptor reviewed G-protein coupled receptor HRH2 IC50 - - -
P08173 BXGT006738 Muscarinic acetylcholine receptor M4 reviewed G-protein coupled receptor CHRM4 Ki - - -
P41143 BXGT010223 Delta-type opioid receptor reviewed G-protein coupled receptor OPRD1 Ki - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR Ki - - -
P08311 BXGT006762 Cathepsin G reviewed Enzyme CTSG IC50 - - -
P07550 BXGT006636 Beta-2 adrenergic receptor reviewed G-protein coupled receptor ADRB2 Potency - 28183 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 IC50 '=' 11000 nM
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Ki - - -
Q12809 BXGT013267 Potassium voltage-gated channel subfamily H member 2 reviewed Ion channel KCNH2 IC50 - - -
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 37685 nM
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Ki - - -
P08183 BXGT006741 ATP-dependent translocase ABCB1 reviewed Transporter ABCB1 Inhibition '=' 56 %
P00390 BXGT005526 Glutathione reductase, mitochondrial reviewed Enzyme GSR Ki '=' 17400 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 63 %
O35505 BXGT004533 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - CACNA1C Inhibition - - -
P25929 BXGT009078 Neuropeptide Y receptor type 1 reviewed G-protein coupled receptor NPY1R Ki - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 Ki - - -
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Ki - - -
P04150 BXGT006154 Glucocorticoid receptor reviewed Nuclear receptor NR3C1 IC50 - - -
P25105 BXGT009021 Platelet-activating factor receptor reviewed G-protein coupled receptor PTAFR IC50 - - -
P14780 BXGT008053 Matrix metalloproteinase-9 reviewed Enzyme MMP9 IC50 - - -
P15127 BXGT008085 Insulin receptor reviewed - Insr IC50 - - -
P18825 BXGT008426 Alpha-2C adrenergic receptor reviewed G-protein coupled receptor ADRA2C Ki - - -
P13945 BXGT007972 Beta-3 adrenergic receptor reviewed G-protein coupled receptor ADRB3 IC50 - - -
P05177 BXGT006336 Cytochrome P450 1A2 reviewed Enzyme CYP1A2 Ki - - -
P14902 BXGT008065 Indoleamine 2,3-dioxygenase 1 reviewed - IDO1 IC50 - - -
P11473 BXGT007709 Vitamin D3 receptor reviewed Nuclear receptor VDR Potency - 10000 nM
P25100 BXGT009017 Alpha-1D adrenergic receptor reviewed G-protein coupled receptor ADRA1D IC50 - - -
P51681 BXGT010878 C-C chemokine receptor type 5 reviewed G-protein coupled receptor CCR5 Ki - - -
Q09470 BXGT013037 Potassium voltage-gated channel subfamily A member 1 reviewed Ion channel KCNA1 IC50 '=' 96000 nM
P51449 BXGT010846 Nuclear receptor ROR-gamma reviewed Nuclear receptor RORC Potency - 66824 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 18650 nM
O15439 BXGT004169 Multidrug resistance-associated protein 4 reviewed Transporter ABCC4 IC50 '=' 16600 nM
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 AC50 '=' 10000 nM
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 IC50 - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE Ki '=' 5011 nM
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' -21 %
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F Ki '=' 14 nM
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D Ki '=' 14 nM
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S Ki '=' 14 nM
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Ki '=' 14 nM
P51589 BXGT010867 Cytochrome P450 2J2 reviewed - CYP2J2 IC50 '=' 3060 nM
Q99549 BXGT019932 M-phase phosphoprotein 8 reviewed Epigenetic regulator MPHOSPH8 Potency - 39810 nM
O95342 BXGT005373 Bile salt export pump reviewed Transporter ABCB11 IC50 '=' 64000 nM
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C IC50 '=' 55 nM
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F Ki '=' 15 nM
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D Ki '=' 15 nM
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S Ki '=' 15 nM
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Ki '=' 15 nM
P22002 BXGT008717 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed - Cacna1c Inhibition - - -
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 IC50 '=' 5420 nM
Q06432 BXGT012876 Voltage-dependent calcium channel gamma-1 subunit reviewed Ion channel CACNG1 Inhibition '=' 32 %
Q9BXT2 BXGT022655 Voltage-dependent calcium channel gamma-6 subunit reviewed Ion channel CACNG6 Inhibition '=' 32 %
O60359 BXGT022652 Voltage-dependent calcium channel gamma-3 subunit reviewed Ion channel CACNG3 Inhibition '=' 32 %
Q8WXS5 BXGT022657 Voltage-dependent calcium channel gamma-8 subunit reviewed Ion channel CACNG8 Inhibition '=' 32 %
Q9UBN1 BXGT022653 Voltage-dependent calcium channel gamma-4 subunit reviewed Ion channel CACNG4 Inhibition '=' 32 %
Q9Y698 BXGT022323 Voltage-dependent calcium channel gamma-2 subunit reviewed Ion channel CACNG2 Inhibition '=' 32 %
Q9UF02 BXGT022654 Voltage-dependent calcium channel gamma-5 subunit reviewed Ion channel CACNG5 Inhibition '=' 32 %
P62955 BXGT022656 Voltage-dependent calcium channel gamma-7 subunit reviewed Ion channel CACNG7 Inhibition '=' 32 %
P54284 BXGT011039 Voltage-dependent L-type calcium channel subunit beta-3 reviewed Ion channel CACNB3 Inhibition '=' 32 %
Q02641 BXGT012659 Voltage-dependent L-type calcium channel subunit beta-1 reviewed Ion channel CACNB1 Inhibition '=' 32 %
Q08289 BXGT012979 Voltage-dependent L-type calcium channel subunit beta-2 reviewed Ion channel CACNB2 Inhibition '=' 32 %
O00305 BXGT003907 Voltage-dependent L-type calcium channel subunit beta-4 reviewed Ion channel CACNB4 Inhibition '=' 32 %
Q15878 BXGT022659 Voltage-dependent R-type calcium channel subunit alpha-1E reviewed Ion channel CACNA1E Inhibition '=' 32 %
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F Inhibition '=' 32 %
Q9P0X4 BXGT021293 Voltage-dependent T-type calcium channel subunit alpha-1I reviewed Ion channel CACNA1I Inhibition '=' 32 %
Q7Z3S7 BXGT022658 Voltage-dependent calcium channel subunit alpha-2/delta-4 reviewed Ion channel CACNA2D4 Inhibition '=' 32 %
O43497 BXGT004596 Voltage-dependent T-type calcium channel subunit alpha-1G reviewed Ion channel CACNA1G Inhibition '=' 32 %
Q00975 BXGT012558 Voltage-dependent N-type calcium channel subunit alpha-1B reviewed Ion channel CACNA1B Inhibition '=' 32 %
O00555 BXGT003936 Voltage-dependent P/Q-type calcium channel subunit alpha-1A reviewed Ion channel CACNA1A Inhibition '=' 32 %
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D Inhibition '=' 32 %
Q9NY47 BXGT021249 Voltage-dependent calcium channel subunit alpha-2/delta-2 reviewed Ion channel CACNA2D2 Inhibition '=' 32 %
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S Inhibition '=' 32 %
Q8IZS8 BXGT018372 Voltage-dependent calcium channel subunit alpha-2/delta-3 reviewed Ion channel CACNA2D3 Inhibition '=' 32 %
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Inhibition '=' 32 %
P54289 BXGT011040 Voltage-dependent calcium channel subunit alpha-2/delta-1 reviewed Ion channel CACNA2D1 Inhibition '=' 32 %
O95180 BXGT005358 Voltage-dependent T-type calcium channel subunit alpha-1H reviewed Ion channel CACNA1H Inhibition '=' 32 %
P23975 BXGT008935 Sodium-dependent noradrenaline transporter reviewed Transporter SLC6A2 Ki - - -
Q15746 BXGT013591 Myosin light chain kinase, smooth muscle reviewed Kinase MYLK IC50 '=' 2020 nM
Q06432 BXGT012876 Voltage-dependent calcium channel gamma-1 subunit reviewed Ion channel CACNG1 Inhibition '=' 40 %
Q9BXT2 BXGT022655 Voltage-dependent calcium channel gamma-6 subunit reviewed Ion channel CACNG6 Inhibition '=' 40 %
O60359 BXGT022652 Voltage-dependent calcium channel gamma-3 subunit reviewed Ion channel CACNG3 Inhibition '=' 40 %
Q8WXS5 BXGT022657 Voltage-dependent calcium channel gamma-8 subunit reviewed Ion channel CACNG8 Inhibition '=' 40 %
Q9UBN1 BXGT022653 Voltage-dependent calcium channel gamma-4 subunit reviewed Ion channel CACNG4 Inhibition '=' 40 %
Q9Y698 BXGT022323 Voltage-dependent calcium channel gamma-2 subunit reviewed Ion channel CACNG2 Inhibition '=' 40 %
Q9UF02 BXGT022654 Voltage-dependent calcium channel gamma-5 subunit reviewed Ion channel CACNG5 Inhibition '=' 40 %
P62955 BXGT022656 Voltage-dependent calcium channel gamma-7 subunit reviewed Ion channel CACNG7 Inhibition '=' 40 %
P54284 BXGT011039 Voltage-dependent L-type calcium channel subunit beta-3 reviewed Ion channel CACNB3 Inhibition '=' 40 %
Q02641 BXGT012659 Voltage-dependent L-type calcium channel subunit beta-1 reviewed Ion channel CACNB1 Inhibition '=' 40 %
Q08289 BXGT012979 Voltage-dependent L-type calcium channel subunit beta-2 reviewed Ion channel CACNB2 Inhibition '=' 40 %
O00305 BXGT003907 Voltage-dependent L-type calcium channel subunit beta-4 reviewed Ion channel CACNB4 Inhibition '=' 40 %
Q15878 BXGT022659 Voltage-dependent R-type calcium channel subunit alpha-1E reviewed Ion channel CACNA1E Inhibition '=' 40 %
O60840 BXGT004901 Voltage-dependent L-type calcium channel subunit alpha-1F reviewed Ion channel CACNA1F Inhibition '=' 40 %
Q9P0X4 BXGT021293 Voltage-dependent T-type calcium channel subunit alpha-1I reviewed Ion channel CACNA1I Inhibition '=' 40 %
Q7Z3S7 BXGT022658 Voltage-dependent calcium channel subunit alpha-2/delta-4 reviewed Ion channel CACNA2D4 Inhibition '=' 40 %
O43497 BXGT004596 Voltage-dependent T-type calcium channel subunit alpha-1G reviewed Ion channel CACNA1G Inhibition '=' 40 %
Q00975 BXGT012558 Voltage-dependent N-type calcium channel subunit alpha-1B reviewed Ion channel CACNA1B Inhibition '=' 40 %
O00555 BXGT003936 Voltage-dependent P/Q-type calcium channel subunit alpha-1A reviewed Ion channel CACNA1A Inhibition '=' 40 %
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D reviewed Ion channel CACNA1D Inhibition '=' 40 %
Q9NY47 BXGT021249 Voltage-dependent calcium channel subunit alpha-2/delta-2 reviewed Ion channel CACNA2D2 Inhibition '=' 40 %
Q13698 BXGT013392 Voltage-dependent L-type calcium channel subunit alpha-1S reviewed Ion channel CACNA1S Inhibition '=' 40 %
Q8IZS8 BXGT018372 Voltage-dependent calcium channel subunit alpha-2/delta-3 reviewed Ion channel CACNA2D3 Inhibition '=' 40 %
Q13936 BXGT013404 Voltage-dependent L-type calcium channel subunit alpha-1C reviewed Ion channel CACNA1C Inhibition '=' 40 %
P54289 BXGT011040 Voltage-dependent calcium channel subunit alpha-2/delta-1 reviewed Ion channel CACNA2D1 Inhibition '=' 40 %
O95180 BXGT005358 Voltage-dependent T-type calcium channel subunit alpha-1H reviewed Ion channel CACNA1H Inhibition '=' 40 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF01386 Asarum heterotropoides Asarum heterotropoides Others
BXGF05627 Asarum sieboldii Asarum sieboldii Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease